Research of the Week
Researchers uncover strong links  between disrupted circadian rhythm, bipolar disorder, and suicide.
Early humans bred with other hominid groups  to gain cold tolerance.
Prenatal phthalate exposure linked  to early childhood language delays.
Hopefully this  is also the last study of its kind.
New Primal Blueprint Podcasts
Episode 288: Ali Miller RD, LD, CDE : Host Elle Russ chats with Ali Miller about the power of food to impact anxiety and mental health.
Episode 289: Dr. Cate Shanahan : Host Brad Kearns chats with Dr. Cate Shanahan, who dispels many of the myths surrounding keto and ancestral eating.
Each week, select Mark’s Daily Apple blog posts are prepared as Primal Blueprint Podcasts. Need to catch up on reading, but don’t have the time? Prefer to listen to articles while on the go? Check out the new blog post podcasts below, and subscribe to the Primal Blueprint Podcast here  so you never miss an episode.
A study that claimed low-carb dieting was terrible for heart health has been retracted  due to concerns with data integrity and conflict of interest.
Hustle porn—the fetishization of extremely long working hours—is a grave danger, according to Reddit’s founder .
Reader Question of the Week
Regarding fasted workouts, Chim Richalds asked :
What about for someone who isn’t fat adapted? I take a fairly liberal primal approach which is high in all 3 macros, am I likely to still see the benefits?
Yes, you will see the benefits.
Fasted workouts (and fasts in general) are going to be more difficult to initiate for the average person eating higher-carb. It may be hard to decide to train in a fasted state and actually stick with it. But I’d argue they might even be more important, the more carbs you typically eat.
Fasted workouts supercharge the fat-burner within all of us. I’ve always said that everyone should spend time in a ketogenic state from time to time, even if they’re eating a high carb diet. The best way for a high-carb dieter to reach ketosis is through the occasional (or regular) fasted workout.
Fat oxidation goes up.
Glycogen drops (from utilization). You can’t help but turn to fat for energy.
Mitochondrial function improves. You may even start building new mitochondria that are better at burning fat.
Metabolic flexibility increases. This is the phenomenon of that athlete everyone knows who can eat whatever and still look and feel great. High enough activity levels bestow a superhuman metabolic furnace.
Interesting Blog Posts
Genes have a limited effect  on longevity.
How neutral is evolution , really?
A meat tax may be coming .
Ithaca becomes the world’s first official  “Free Range Kids Town.”
The first Native Americans spread out  over North and South America incredibly quickly.
I’ll take “gym obsession ” over total lack of regard for one’s health, athleticism, and body composition.
Things I’m Up to and Interested In
Any parent or teacher knows this: Smartphones are more reinforcing than food .
I keep saying: It’s never too late to start lifting heavy things .
Concept I’m pondering: Ecological amnesia .
Another concept I’m pondering: The arts as shadow health service .
Development I welcome: The medical apostates who want to utilize the placebo effect as powerful first line treatment .
Question I’m Asking
Do you think a meat tax is coming? What would be the fallout?
One year ago (Nov 4– Nov 10)
- The Insulin-Illness Connection  – Don’t make this connection.
- Top 10 Paleo Apps  – Make your screen time worth something.
Comment of the Week
“I’m 45, but identify as a 25 year old. haha. I’m going to stick with this for a while and see what happens.”
– Amen, Scout .