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October 21 2018

Weekend Link Love — Edition 526

By Mark Sisson
15 Comments

Research of the Week

A low-carb, high-fat diet improves glucose control and lowers fasting insulin in people with Type 2 diabetes, whether they walk after meals or not.

Many cases of dementia may come down to non-inherited random errors during DNA replication.

An active commute through natural settings is a reliable recipe for good mental health.

Human neurons are uniquely powerful and self-contained.

Blue light is more disruptive to sleep when viewing emotionally salient material.

New Primal Blueprint Podcasts

Episode 283: Jolene Goring: Host Elle Russ chats with Jolene Goring about the powerful effects of systemic enzymes.

Each week, select Mark’s Daily Apple blog posts are prepared as Primal Blueprint Podcasts. Need to catch up on reading, but don’t have the time? Prefer to listen to articles while on the go? Check out the new blog post podcasts below, and subscribe to the Primal Blueprint Podcast here so you never miss an episode.

Interesting Blog Posts

How to raise less materialistic kids.

Music makes living through conflict bearable.

Media, Schmedia

Nebraska school cook serves kangaroo chili, gets bounced from job.

The implications of consumer gene tests are always changing.

Everything Else

Chinese city to launch a fake moon with a “dusk-like glow” to replace streetlights.

Why didn’t ancient literature discuss “feelings”?

Humans are unique in our ability to produce ketones.

Things I’m Up to and Interested In

Videos I’m loving: The videos from the 2018 Ancestral Health Symposium are live!

Study I’ll have to take a closer look at: The more exercise, the better.

This is another reason why I love entrepreneurship: Entrepreneurs may have saved the bees.

Study I’m, well, studying: High cholesterol in keto-adapted athletes.

I’m not surprised: The World Health Organization ignored two major studies into the health effects of meat when writing its analysis of meat’s dangers.

Recipe Corner

Time Capsule

One year ago (Oct 14–Oct 20)

Comment of the Week

“More great ‘anti-hype’ from Mark Sisson!”

– Thanks, Philip May. Nice description of what I try to do.

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15 thoughts on “Weekend Link Love — Edition 526”

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  1. Regarding Chengdu’s project: in fact, putting shades (even better if they block only IR and let visible light through) in orbit would be more useful, as they could cool down the Earth…

  2. As far as “the more exercise the better” study I wonder if folks who had to drop out of long distance cardio training due to injuries or cortisol driven exhaustion are considered in the equation? In other words, if you can tolerate chronic cardio you may live longer, otherwise it might break you down. Everyone has a sweet spot for exercising is my gut feeling and you have to “listen to your body”. I still like the primal mantra along the lines of (if I may be so presumptuous as to paraphrase Mark) “walk a lot, do sprints once a week, lift heavy things once or twice a week, spend time outdoors, take part in sports or recreational activities that are fun for you”.

  3. Per the link, Continental Atlantic Rivers are the first listed natural feature! That means walking across the Brooklyn Bridge constitutes a healthy commute!

  4. Anybody interested in bee colony collapse who hasn’t heard of the work that Paul Stamets [mycologist] is doing should look into it.

  5. I would like to see a whole post on the “More exercise is better” topic. There is definitely contradictory research as well as other individual experiences. Look at our Special Forces training -Navy Seals for example…and not just BUD/s but ongoing during service. Maybe it just depends on your goal. It does seem that the human body can take an incredible about of stress and still respond favorably?

  6. That outlook on hypercholesterolaemia in keto adapted “athletes” is very interesting. I consider myself an athlete, not professional though, and I have recently completed a 7 week keto regimen, at the end of which, I submitted some basic blood work. Well, my LDL was off the charts. Now, I can’t say that I was too surprised, but I was a wee bit disappointed. However, when I looked at my Triglyceride to HDL ratio (more and more seen as the most definitive measure of all cause mortality), it was as low as it possibly can get, apparently. The lower the ratio, the better. Yea, keto..though I’m sure my consistent visits to Primal territory have given me a head start on those numbers.

    1. You need to know your LDL particle number and Apo B levels–if those are elevated you are at risk for atherosclerosis. If your LDL is “off the charts” this could be you. Check out Dr Peter Attia’s interview with world renowned lipidologist Dr Thomas Dayspring. It’s very detailed but the jist of it is LDL-P and Apo B is all that really matters when it comes to atherosclerotic risk. The HDL to triglyceride ratio really means nothing, according to Dayspring, and he’s more qualified than anyone on the internet to make this claim. It’s a 5 part podcast, I linked to the first one below:

      https://peterattiamd.com/tomdayspring1/

      1. In my humble opinion, Dayspring said that HDL to triglyceride is such a good marker because it is predictive of ApoB. The question is whether all these keto hyperresponders have discordant HDL/trigs and ApoB levels.

        1. Did he say that in the podcast with Attia? If so I must’ve missed that particular comment(s) about HDL/Trigs. The point he kept hammering thought was the importance of knowing LDL p and Apo B for atherosclerotic risk: if someone’s LDL-C is “off the charts” they need to know LDL p and Apo B numbers.

          Tom Dayspring: As we had all these lipid metrics that we’re talking about, cholesterol, even triglyceride metrics, deep down the guys know these are just poor man’s way, easily assayable ways of quantifying lipoproteins. And it’s a [particle] quantification that matters in many cases.

          Tom Dayspring: So, it turns out, in the long run, it’s the number of apoB particles (Figures 9 and 10) that primarily is what forces it into the artery wall. Very little else matters, I mean there are other factors, but that’s the number one factor.

          Tom Dayspring: So that’s the real key, and if you ever go to a doctor and you’re told “I’m very happy because your LDL-cholesterol is normal,” say “Well so am I doc, but by the way, what was the apoB or LDL particle count (Figure 14)?” And if the doctor didn’t do it, you demand he do it instantly because otherwise, you don’t know your lipid-related risk.

          1. Peter Attia: Correct. It (LDL-C that is) turned out to be less predictive then the absolute level of HDL-C and triglyceride. A lot of people like to stop at that and say, “Look, that means LDL doesn’t matter.” What they don’t realize is those are two enormous proxies for apoB.

            Tom Dayspring: That’s all they are. And virtually all of your insulin resistant patients are getting atherosclerotic disease. It’s apoB. It’s LDL particle mediated because everybody who’s not on a drug or a serious diet who had a triglyceride HDL cholesterol axis abnormality has astronomical apoB.

          2. So, if people have excellent HDL/trig ratios (pointing to a low ApoB particle count) and high LDL-c levels (pointing to a high ApoB particle count), what is true? Is the HDL/trig ratio misleading or the high LDL?

  7. I remember a Kellogg’s commercial from last year about the plight of bees. I can’t find it quickly enough to bother to continue searching but they’re flashing stuff on the screen like “The bees are in decline” and playing a song “Take these broken wings”; it was all very emotional.
    “Help us plant a million wildflowers”.
    What a publicity stunt! They’re probably responsible for a lot of the bees dying and I don’t think planting a million more wildflowers is really going to do all that much to help them. It’s not like they’re starving, but rather being poisoned.