Weekend Link Love – Edition 461

weekend_linklove in-lineRESEARCH OF THE WEEK

A father’s absence triggers cellular stress in children.

Big new trans-ethnic Alzheimer’s study finds several new genetic variants associated with the disease.

Ketamine saves suicidal teens.

Lung cancer patients undergoing successful treatment experience spontaneous re-pigmentation of gray hair.

Dogs split from a now-extinct group of wolves about 40,000 years ago.

A black tea polyphenol (called mitochondria activation factor) enhances hypertrophy in rodents.


Episode 78: Aarn Farmer: Aarn Farmer used to weigh over 400 pounds with full-blown metabolic syndrome. Two years of low-carbing followed by a ketogenic diet helped him drop 175 pounds and eliminate his metabolic syndrome. This is his story.

Each week, select Mark’s Daily Apple blog posts are prepared as Primal Blueprint Podcasts. Need to catch up on reading, but don’t have the time? Prefer to listen to articles while on the go? Check out the new blog post podcasts below, and subscribe to the Primal Blueprint Podcast here so you never miss an episode.


Rock climbing therapy for brain injuries—a fast track toward Zen-like brain states.

If you want to be part of a carnivore study, sign up here.


Soylent: Coming to 7-11. Good thing they have bathrooms.

Nutritional heretic Gary Taubes explains why carboholism makes cutting carbs so difficult for so many.

Obesity experts question statin claims (again).


A 101-year old sprinter who just casually broke the 100m world record for her age group gave a post-race interview, which hinted at the reasons for her robust health: naps, “outside all the time,” three generations of offspring, indifference to the outcome.

Your brain is made of memories.

Beautiful fish swimming off the coast of Northern California.


New book I’m interested in: Crazy-Good Living, from Primal Health Coach and nutritional periodontist Dr. Al Danenberg.

Research I found interesting: Even people with neuroscience backgrounds believe common brain myths.

Older article I’m digging: “WHO Says Meat Causes Cancer?

I always like to see conventional wisdom refuted: Usain Bolt’s weird stride is what makes him run so fast.

News I did not enjoy: The CDC estimates there are more than 100 million Americans with diabetes or prediabetes.



One year ago (Jul 23– Jul 29)


PSA: the people-mover at the airport isn’t for standing in place. It’s there to help you walk faster to the gate that’s a mile away, but must be reached in eight minutes. I feel like the Flash power-walking on those things.

– I do the same thing, HisDudeness.

About the Author

Mark Sisson is the founder of Mark’s Daily Apple, godfather to the Primal food and lifestyle movement, and the New York Times bestselling author of The Keto Reset Diet. His latest book is Keto for Life, where he discusses how he combines the keto diet with a Primal lifestyle for optimal health and longevity. Mark is the author of numerous other books as well, including The Primal Blueprint, which was credited with turbocharging the growth of the primal/paleo movement back in 2009. After spending three decades researching and educating folks on why food is the key component to achieving and maintaining optimal wellness, Mark launched Primal Kitchen, a real-food company that creates Primal/paleo, keto, and Whole30-friendly kitchen staples.

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29 thoughts on “Weekend Link Love – Edition 461”

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  1. The Bombay Beef Meatballs recipe struck me. I wonder if the recipe writer realizes Hindu nationalists are murdering people in India who they suspect are eating or trading in beef.

    “Cow protection has been a trigger for sectarian violence throughout modern Indian history and its resurgence since 2015 has been linked to an increasingly assertive Hindu nationalist movement.”


  2. Did anyone else pick up on a lot of “spin” in the carboholic article, particularly in the comments section. There are a million reasons out there designed to blame obesity on something other than lack of willpower, yet, ultimately, that’s exactly what it boils down to. Bottom line: we have ABSOLUTE CONTROL over what we put in our mouths, and we HAVE to be willing to do what needs to be done to reduce the carbs, get rid of the excess weight, and keep that weight off. Saying “But it’s not my fault” is just a distraction. It doesn’t get the job done.

    1. Did anyone pick up on the “spin” in the article about children who are thought to have genetic damage from being fatherless.? It goes to great lengths, and with clear bias, that this is a jab at society (evaluating family dynamics but not elaborating on father roles) for incarcerating men and “causing” shortened telomeres of children DNA. Incarceration is always first on the list……beating death, illness, accident and other misfortunes.

      The article is so bold as to claim that this has major “policy” implications.

      1. I did notice that. Considering all the wars there have been throughout history and all the kids who have, for whatever reason, grown up fatherless, we must be a pretty damaged bunch of human beings. It used to be “I’m okay, you’re okay.” Now it’s gotten to be a case of “Nobody is okay.” Typical shrink-think.

    2. I have a hard time believing statements like that because I eat a high carb diet (particularly in the summer) and I can’t gain weight at all. My BMI is forever 18, no matter what I eat. Now, maybe it’s only a case of how many calories I eat but why I can eat until I’m full everyday, no matter how carby and somebody else gain weight while limiting themselves?

      I need to add that my mobility is greatly impaired by my chronic illnesses so it’s not because I burn all that I eat.

      1. “Can’t gain weight at all “+”chronic Illnesses” + “eat a high carb diet”… = have you been tested for Celiac’s Disease yet?

        1. Yes, I have. I’m not too sure I’ve done it right though. I read on the internet that you need to eat gluten for 2 weeks prior to the test and I only ate some for 4 days and it was not much either…

          The funny thing is that only yesterday my dad told me when he was a toddler, the doctor said to my grand-mother that he wouldn’t live longer than 10 years because he was always sick and super skinny. I asked him if ever had been tested for Celiac and he dismissed it even after I told him it was a sign.

      2. Coccinelle — “….I have a hard time believing statements like that because I eat a high carb diet (particularly in the summer) and I can’t gain weight at all. My BMI is forever 18, no matter what I eat…….”

        Well…. you don’t believe us, but I believe you. Because I have several friends in the same boat as you: even unto their 40s and 50s they can carb out and not gain an ounce. In which case: bon appetit! Why restrict your diet if you don’t have to?

        The difference, according to research, is ultimately GENETIC. Some people’s bodies are “wired” to overreact to carbs by going into hyperinsulinemia, and some people are not. If you are fortunate enough to NOT have that trait, you can carb out as you please.

        1. I agree! My point is: if it’s genetic for me, it’s also genetic for the overweight person, so why say that this person has no willpower?

          1. Because you still control what and how much you eat. There is absolutely no other way to gain weight than by what you put in your mouth, whether genetically geared to be overweight or not. The trick, then, for overweight persons, is to understand that they can’t “carb out” if they know it packs on the pounds. That’s where willpower comes into play. Being unable to gain weight isn’t the same situation.

  3. I can relate to the carboholism article. The behavior he describes is me to a T. I get kind of panicky when I think about giving up things like ice cream, which, to me, is an indication of an addiction.

  4. Love the link: Nutritional heretic Gary Taubes explains why carboholism makes cutting carbs so difficult for so many.

    If carbs were booze, I would be sleeping under a bench somewhere next to a shopping cart full of cats.

    1. Hand over the cupcakes and nobody will get hurt! Yes, carbaddict here too but I’ve come a long way.

  5. Donovan Bailey had an irregular stride as well, even more pronounced that Bolt’s, and held the world record over 100m.

    1. Yes…but wasn’t he one the athletes who was “juiced” to the max? Correct me if I am mistaken.

  6. As a man whose hair started going gray at age 25, the cancer treatment/repigmentation article piqued my interest. Maybe one day some scientician will isolate whatever it is in the treatment that causes it.

    1. It isn’t what’s in the treatment; it’s what the treatment does to the hormones. After my second child was born, my normally chestnut-brown hair turned pitch black. Nobody would believe I didn’t dye it. Six months or so later it went back to being brown.

    2. At 49 years old I have friends younger than me who are almost all gray but I only have a few gray hairs. It’s probably partially genetic but I also think making sure I get enough magnesium, Himalayan salt, and related minerals is part of it.

  7. Good stuff as always Mark I just beg you to never publish a link to an article that states eating a couple of bites of 85% chocolate every day is bad for me. 🙂

  8. The article about Usain is pretty interesting. I think asymmetry is another topic worth discussing more in the health blogosphere. Asymmetry is very natural actually, in the face, and the whole body. So yea he’s slightly asymmetric but aren’t we all..

    1. Now all aspiring sprinters will bend their spines, chop off 1/2 inch of leg. Reminds me of Who opera Tommy.

  9. I would suggest that a certain skepticism is in order for this “genetic” article on AD, and if fact most genetic articles regarding diseases that are complex and multisystem.. There is lots of enthusiasm for genetics in science since we have developed a robust government funding program and an inclination to aggregate data for “deep” analysis by powerful supercomputers. The genetic theories regarding disease is turning out to be woefully problematic, partly due to the law of large numbers and the fact that the more variables in a data set, the higher the probabilities of spurious correlations. However, one needs to look no further than the dismal outcome of the trillion dollar genome sequencing endeavor and improving understanding and treatment of cancer. It’s so complex that the most ardent supports of the somatic mutation theory have resorted to a magical “dark matter” , yet to be discovered , in order for it to make sense.

    In the meantime there is the matter of epigenetics……which zooming up the ladder of popularity, but it at least dispenses with much of the problem of genetic determinisms and the idea that mutations and “bad luck” genes are going to get you.

    Now we are showing new respect for metabolic theories and models of disease and tying it up, so to speak, with issues of “energetics” or more accurately progressive problems with mitochondrial function…..and downstream phenomenon of the problem of tremendous production of random somatic mutations, which we take as “causal”.

    All this genetic data mining, while not a big waste, but very distracting.

  10. Under the Time Capsule section I read the 2nd headline as “How LASAGNA Affects Your Fitness and Weight Loss Practice.” I might need a carb intervention.

  11. Always look forward to these Sunday posts…can always find something to catch my interest. Enjoyed the rock climbing article. I used to do top roping on a regular basis (at an indoor rock gym…although I’d love to do it outdoors). Not only is it an amazing all over workout, I can definitely attest to the zen-like state. You are using your mind as much as your body, and totally forget everything else. As someone who was never athletic as a kid, I also found it a great confidence builder.

  12. I have never tried Soylent, but I am intrigued by the idea of moving away from meat based products. If only they could come up with a high fat, animal free drink!