Weekend Link Love – Edition 336

Weekend Link LovePrimal Kitchen™ Mayo officially launched this week! You can get single jars at Thrive Market. Register for an account at Thrive Market using this link and you’ll be entered to win a $500 gift certificate and 1 of 20 annual memberships ($60 value). Offer expires Wednesday, Feb. 25. Or you can order 3-packs from PrimalBlueprint.com.

Join me in Manly Beach, Australia next month, and in Southern California next September.

Research of the Week

Topical animal collagen — in this instance, from tilapia skin — quickens wound healing.

Primary prevention risk calculators are overestimating the chance of heart attacks by up to 154% in men and 67% in women. Yup, the very same risk assessments telling us we’ll all die if we don’t start statins immediately.

A key ketone metabolite blocks the inflammatory cascade triggered by a specific set of genes.

“For every hour later of [artificial light exposure] in the day, there was a 1.28 unit increase in BMI…”

New Primal Blueprint Podcasts

Episode 55: Al Kavadlo: Host Brock Armstrong talks to Al Kavadlo, calisthenics wizard, bodyweight training expert, prolific author, and all-around awesome guy about Al’s training philosophy, his books, the role of inspiration in effecting lasting change, and much more.

Each week, select Mark’s Daily Apple blog posts are prepared as Primal Blueprint Podcasts. Need to catch up on reading, but don’t have the time? Prefer to listen to articles while on the go? Check out the new blog post podcasts below, and subscribe to the Primal Blueprint Podcast here so you never miss an episode.

Interesting Blog Posts

Tight hips and hamstrings are at the root of many movement dysfunctions, and people who sit a lot are liable to end up with both. These videos from Angelo dela Cruz will show you how to give your hips and hammies some much-needed love.

Why the sun (and the vitamin D it provides) is so important for your periodontal health.

Media, Schmedia

Low-fat advice was bad advice, admits yet another media outlet.

Citing the latest evidence, Australian doctors are recommending that patients stop antibiotics once they feel better. The full course isn’t actually necessary after all (and may be harmful).

Everything Else

A first-grade teacher in Saskatchewan has outfitted his class with standup desks.

Antibiotic-resistant pathogens are increasingly moving, as pathogens are wont to do, from pigs to people.

Have we gotten the science behind anti-depressants totally backwards?

Scientists have just mapped the epigenome.

Hey, east coasters: keep it down, will ya?

Recipe Corner

Time Capsule

One year ago (Feb 23 – Mar 1)

Comment of the Week

There is apparently some small risk of getting variant Creutzfeldt-Jakob disease (essentially mad cow disease in humans) from elk. The disease agent is a prion, which is resistant to high temperatures, and so the brains, spinal cord, and some other parts shouldn’t even be handled, let alone eaten, in areas where the wild elk population is known to have the disease.


“Hunters who harvest deer or elk from known CWD-positive areas may wish to consider having the animal tested for CWD before consuming the meat (information about testing is available from most state wildlife agencies). Persons involved in field-dressing carcasses should wear gloves, bone-out the meat from the animal, and minimize handling of the brain and spinal cord tissues.”

Risk is small, but still … google “CWD hunters” for more than you ever wanted to know.

– Thanks for the warning, reader Anne and others.

About the Author

Mark Sisson is the founder of Mark’s Daily Apple, godfather to the Primal food and lifestyle movement, and the New York Times bestselling author of The Keto Reset Diet. His latest book is Keto for Life, where he discusses how he combines the keto diet with a Primal lifestyle for optimal health and longevity. Mark is the author of numerous other books as well, including The Primal Blueprint, which was credited with turbocharging the growth of the primal/paleo movement back in 2009. After spending three decades researching and educating folks on why food is the key component to achieving and maintaining optimal wellness, Mark launched Primal Kitchen, a real-food company that creates Primal/paleo, keto, and Whole30-friendly kitchen staples.

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16 thoughts on “Weekend Link Love – Edition 336”

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  1. “For every hour later of [artificial light exposure] in the day, there was a 1.28 unit increase in BMI….”

    ^That article just reinforced my desire to get to bed EARLY again. Anytime I’m up past 9 p.m. I’m not doing anything productive…

    1. All my friends want to disown me since I started to go to bed early… on the weekends. I was already in bed at 9:30 on weekdays, now I have begun to get very close to that on weekends, it works sooooo much better. They all say they want to get the most of their weekend. It’s like they can’t capitulate to the idea that getting up earlier still gives you the same amount of time. It’s called math… use it. Plus, hello? SUNLIGHT! I need new friends.

      1. Dude, I had good friends leave me because I didn’t drink as often and respected my circadian rhythm, always going to sleep by 11… After a year or 2 of it, I kind of decides it’s not worth it during college and switched to a more biphasic sleeping pattern, but i think I feel more tired during the first portion of my day and I’m not the best at naps so sometimes I don’t get my day sleep in
        I would just shift my rhythm forward if I didn’t have to train at 0550

  2. Okay, can someone put the ketone study into English, please.

    About all I understood was “Our findings suggest that the anti-inflammatory effects of caloric restriction or ketogenic diets may be linked to BHB-mediated inhibition of the NLRP3 inflammasome.”

    Googling around produced more science-speak and little illumination.

    Suggestions for a decent on-line biochem course would also be welcomed.

    1. Researchers looked at five of the many inflammatory pathways in mice and found that either a ketogenic diet or exogenous beta-hydroxybutyrate directly blocks one of the five (starvation in general reduces inflammation through unknown or not entirely known mechanisms). Since the pathway in question is associated with a couple of rare genetic diseases in humans, it’s possible that a ketogenic diet or a BHB analog drug could be used to slow the progress of the damage due to these mutations. At least that’s my stab at translation.

      Biochemistry is a pretty vast subject with a lot of highly specialized sub fields. This paper is at the intersection of immunology and biochem.

    2. calcampus offers classes online that you can sign up for. They are not a university or anything so registration is easy. Also, some colleges will accept their courses as credit in case you decide to become a biochem major later in life 🙂

  3. So if we rub some Tilapia skin on our wrinkled faces would that “heal” our wrinkles? Hmmmm, I’ll stick with coconut oil for now, smells better and has been working great so far, still have the wrinkles tho. 😛

  4. Regarding your comment of the week:

    My friend died from Creutzfeldt-Jakob disease.

    As far as anyone knows, he didn’t eat deer or elk or any other wild animals. He was a chronic cardio enthusiast (running) and he bought into the low-fat eating scam.

    We were shocked when the diagnosis was made because it’s usually blamed on eating diseased venison.

  5. Nice job the 1st grade teacher did by giving his students stand-up desks.

  6. Great article on BHB and ketones. This seems to be why resistant starch/indigestible fiber is necessary for a healthy gut biome. Sugar and refined grains may not be inflammatory on their own but perhaps they are not processed into BHB by intestinal flora? I understand grass fed butter is a good detary source of BHB. As a former(thanks Mark) gout sufferer, I have a hunch that nurturing a gut biome that produces BHB may be the solution to a plethora of inflammatory disorders. P.S. I found this Delitia buffalo butter from Italy. It’s as white as lard and tastes like pure CLA. Does anyone else have experience with this? My family does not like it so it has to be good.

  7. Now I feel better about all the times I didn’t finish my course of antibiotics

  8. A C.O.W. regarding mad cow. Maybe I’m a bit reckless but I wouldn’t be worried. Sometimes I don’t even cook all my ground beef and enjoy some raw (usually depending on how hungry / how much of a red meat craving I have and if I’m baking the tube from frozen) and I’ve eaten raw chicken, out of curiosity and to be able to say to myself that I did.
    I had terrible food poisoning twice (quite a while before primal) but I don’t expect to ever get it again. I don’t know much about prions though – I think I might have first learned of them in a Micheal Chrichton book.

  9. Antibiotics. I’m not sure the article suggesting antibiotics be stopped once the patient feels better is accurately portraying the journal article. The original article by Gwendolyn L Gilbert states: ‘In practice the optimal duration of therapy depends on clinical syndrome, the causative organism, whether source control is possible and the patient’s response to therapy.’ The author suggests that antibiotics are often prescribed for longer than necessary, but it’s not as simple as ‘take this until you feel better’.