Meet Mark

Let me introduce myself. My name is Mark Sisson. I’m 63 years young. I live and work in Malibu, California. In a past life I was a professional marathoner and triathlete. Now my life goal is to help 100 million people get healthy. I started this blog in 2006 to empower people to take full responsibility for their own health and enjoyment of life by investigating, discussing, and critically rethinking everything we’ve assumed to be true about health and wellness...

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Tag: toxins

Environmental Toxins and Gene Expression

It’s the heart of the Primal Blueprint: understanding that our lifestyle factors direct influence the expression of our genetic code. While the DNA itself is set, the structure fixed, that’s hardly the end of the story – our story. How we live – even where we live – holds significant sway over the final picture. And by picture I mean, of course, the picture of our genes’ activity: when proteins are produced (and how much), when or whether certain genes are turned on or off. This activity, researchers are increasingly finding, is key in the development – or avoidance – of any number of conditions like Parkinson’s, Alzheimer’s and cancer. Rather than a predetermined formula simply set in motion in the womb, our genes demonstrate a much more complex, nuanced interplay. The sum of all our daily choices and exposures direct our epigenetic signaling and the course laid out by that ongoing sequence of gene activity. As I’ve said many a time, our original genetic heritage doesn’t design our physiological fate. How we live determines how our genes play out their hand. No doubt a powerful concept, the comprehension can take us by surprise. The quickly expanding field of epigenetics has, indeed, rewritten old school genetics. It’s even ruffled a few feathers here and there, but isn’t that always the case with new breakthroughs?

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Dear Mark: Phenylketonurics and Chewing Gum

Dear Mark,

I’ve gone Primal and am loving it! But now you’ve got me questioning everything – even my beloved gum. I’m an avid chewer of the stuff and had never thought twice about. I took a closer look recently and saw all kinds of things I didn’t recognize including a warning about phenylketonurics. What are they and what about all the artificial sweeteners? Would Grok chew gum? If so, what are the healthiest options?

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Are Plastics Safe?

It’s an emblem of the modern culture. Think that Graduate line (“I want to say one word to you. Just one word….”), the commercial a couple decades ago in which the girl drops a 2-liter soda bottle, Tupperware parties, Ziploc bags, etc. Plastics were once cutting edge, and these days they’re absolutely everywhere. They’re so ubiquitous, in fact, that a recent book (The World Without Us) hypothesizes a post-human world with an evolutionary turn toward plastic ingestion. There’s an interesting nutritional concept….

Some weeks ago we tackled the question of safe cookware. While we took on the likes of aluminum, stainless, and ceramic, we knew there was a whole other world of cookware and food storage left to explore. So, today we tackle the question of plastics. What role can/should they play in a Primal kitchen? What price do we pay for their convenience? Is there such a thing as a safe plastic for food prep and storage? What are the ones to avoid at all costs? And what’s the real harm in it anyway?

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Rapid Fire Q&A: Fish Oil Guide Follow-Up

You guys had tons of questions following last week’s Definitive Guide to Fish Oils. Since the back and forth discourse is my favorite part of doing the blog, I’ll see if I can get to all of them. Let me know if I miss anything!

You recommend storing fish oil in the fridge, but how about storing capsules in the freezer? Wouldn’t this be an even better step to take to prevent the oil from oxidizing?

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The Problems with Conventionally Raised Beef

As mentioned in our Red Scare commentary a few weeks ago, beef gets a seriously bad rap these days. “Saturated fat!” the status quo shrieks, running in all directions, hair on fire, arms flailing, gnashing their teeth. Let’s set the record straight here. You know our decidedly pro-fat leanings. No need to go any further there. But what else is there to like about beef? To its credit, beef offers among the biggest boost of protein per ounce of any traditional food. (Yes, insects and other underappreciated delicacies in some cases offer more. We’ll let our good readers fill in the options here.) To boot, beef is an excellent source of niacin, vitamins B6, B12, K2, phosphorus, selenium, as well as iron, potassium, and riboflavin. In its best form (and we’ll get to that), it also serves as a good source of conjugated linoleic acid (more on this in a minute) and omega-3 fatty acids. (See why we were so compelled to defend red meat’s honor?)

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Dear Mark: Considering Cookware

Hi Mark,

I couldn’t find any MDA posts that tackled the matter of cookware possibly leaching heavy metals and/or toxic chemicals into food. I’ve read that a porcelain/ceramic inside surface is the way to go, (thereby avoiding Teflon and metals), but good-quality examples like Le Creuset are darn expensive, and lesser-quality ones like Heuck look like camping gear to me.  Have you researched or concluded anything on this matter?  Is this a non-issue?

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Sodium Nitrite: Another Reason to Avoid Processed Meats

It’s lurking in breakfast meats, lunchboxes and carving stations across the country. Sodium nitrite, that is: preservative and coloring additive extraordinaire. It’s undeniable that we have a penchant for processed foods in this country, and meats are no exception. Bacon, sausages, hot dogs, cold cuts, ham, packaged smoked meats, pates, Slim Jims (everybody’s favorite, right?) – meats many would consider part and parcel of the quintessential American diet. Many of us crave their delectable saltiness and welcome convenience, but are we paying a price for their processing, specifically when sodium nitrite is on the label?

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Are Microwave Ovens Safe?

To Nuke or Not to Nuke?

The verb itself suggests the unleashing of atomic destruction, but we wondered, “Is there a grain of truth behind the slang?” What’s the real story behind these boxes of convenience sitting in so many of our kitchens? Are microwaves a benign bastion of modern handiness or, as some claim, a sinister contributor to our physiological (at least nutritional) undoing?

It’s likely that we find ourselves in a variety of camps on this issue. Some of us swear them off. Others unapologetically swear by them to get through the normal course of a busy day. And then there are those of us in the dithering middle who routinely stare at each plate of leftovers or bowl of frozen vegetables, sometimes reaching for the pots and pans and other times giving into convenience but always questioning whether we’re paying for it.

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Aflatoxins, or Another Reason to Shun Peanuts

We already tend to steer clear of peanuts for some obvious (to our readers) reasons: the fact that they’re legumes, rather than actual nuts; the potentially dangerous, “anti-nutrient” lectins found in them; and their prominent spot in the upper echelons of the “Most Common Food Allergens” list. But there’s another reason to steer clear of peanuts, something we’ve touched on briefly in the past but never expounded upon. Peanuts, along with a couple other crops we tend to avoid, like corn and cereals, are especially susceptible to a mold that produces a mycotoxin called aflatoxin.

Aflatoxin is a carcinogen that has been shown to cause liver cancer in rats (and, presumably, in humans). The amounts given to the rats in the study were highly concentrated, of course, with the express intent to study the effects of acute aflatoxicosis. You won’t be getting a couple grams of aflatoxin with every bag of peanuts or anything, so acute aflatoxicosis isn’t a big issue for people – at least in the US.

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Challenging Assumptions

Here at Mark’s Daily Apple, we talk about food a lot. The Primal Blueprint is basically founded on the notion that following the approximated diet and lifestyle of our Primal ancestors is the key to lasting health. A large portion of our posts center on examining long-held conventional wisdom about food – ridiculous stuff like “fat is bad,” “carbo-loading is necessary for any athlete,” “avoid egg yolks,” and “vegetarianism represents the pinnacle of dietary health.” Time and time again, we’ve shown that blindly subscribing to popular notions about food is not only misinformed, but also potentially damaging. It is only through examination that we progress and learn; taking “food experts” and Big Pharma at their word has been shown to be a grave misstep. And so, with this in mind, we move to examine two new scientific developments that question some fairly entrenched dietary conventional wisdom.

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