Meet Mark

Let me introduce myself. My name is Mark Sisson. I’m 63 years young. I live and work in Malibu, California. In a past life I was a professional marathoner and triathlete. Now my life goal is to help 100 million people get healthy. I started this blog in 2006 to empower people to take full responsibility for their own health and enjoyment of life by investigating, discussing, and critically rethinking everything we’ve assumed to be true about health and wellness...

Tell Me More
Stay Connected

Tag: hormones

7 Longevity Biomarkers to Track

Last year, I wrote about 10 of the most interesting predictors of longevity. Many of them were subjective, but, as we all know, the objective physiological processes that occur in the human body also predict how long we live. Luckily, we can measure most of them. Some are standard at doctor’s checkups. Some require more involved (and expensive) testing. Some you can complete yourself at home with simple household objects.

But if you care at all about how well you’re doing in the longevity game, it’s worth paying attention to some of them.

Read More

Dear Mark: Hormone Normalizing Questions

For today’s edition of Dear Mark, I’m answering questions from last week’s hormone normalization post. First I discuss a lack of purpose in the mornings affecting sleep and what to do about it. Next, I explore the prospect of sun and fasting as hormone modulators. After that, I explain the meaning of max aerobic heart rate and correct a mistake I made. And finally, I suggest to one reader that she may need to eat more calories to normalize her sleep and thus her hormones.

Read More

9 Ways to Normalize Your Hormones

There are straightforward, pharmaceutical methods for altering specific hormones, and, as I showed in last week’s testosterone replacement therapy post, they can really help. But a safer intervention for your overall endocrine environment is a systemic one. Some might call it scattershot approach in that one input affects multiple endocrine targets. I’d say, “That’s the whole point.”

Today, I’m going to give you some tried and true methods for helping to normalize your endocrine health. These are things that apply to everyone, as far as I can tell. They won’t fix every problem, but they’re good places to start. Whether you’re a post-menopausal woman, a 21-year-old bodybuilder worried about overtraining, or a thyroid patient, these interventions can’t hurt and will probably help.

Read More

Dear Mark: TRT Edition

Last week’s post on testosterone replacement therapy generated a lot of comments and questions, so for today’s edition of Dear Mark I’ll be answering some of them.

From the prostate and heart disease issues to the high T/low free T phenomenon to the question of women and TRT to keto’s effect on testosterone to chronic cardio’s, you folks came up with some good ones.

Read More

Testosterone Supplementation: My Primal Take

After I turned 60, a routine checkup showed that I had lower-than-normal free testosterone levels. I hadn’t noticed anything that would have alerted me. No symptoms. No indication. Everything worked well. But it nagged at me. I knew testosterone did much more for a man’s health than just “build muscle”—which I had no real interest in at this point—so I decided to explore TRT, or testosterone replacement therapy.

I did a careful survey of the literature, coming away pleasantly surprised. The evidence was almost uniformly in favor, with the well-constructed studies showing major benefits for TRT. This is TRT, mind you. Not “juicing,” not steroid abuse. Restoration of biologically-appropriate levels of testosterone. Thus began my experiment….

Read More

Is Keto Bad for the Thyroid?

Keto is fantastic, everyone says. It’s a great way to lose weight, improve cognition, and stave off degenerative disease. It may help your performance in the gym and on the track. It could even give Grandpa some respite from Alzheimer’s.

But it’s hell on your thyroid. Right?

Keto detractors and proponents alike often warn that remaining in ketosis will tank your thyroid. The thyroid’s an important gland, exerting major influence over essential systems like fertility, energy, metabolism, body temperature regulation, blood lipids, and general wellness. It controls the metabolic rate of every organ in the body. We want it working well, so this is a major blow to keto—if the criticism holds true. Fortunately, there’s much more to this story.

Read More

Dear Mark: Why are Male Fertility and Testosterone Levels so Low?

For today’s edition of Dear Mark, I’m answering just one question. But it’s a good (well, maybe not good, but certainly important) one: Why is male fertility on the rise and testosterone on the wane? The popular notion is that women flushing birth control pills and peeing estrogen-rich urine into the public water supply are the primary reasons for the sex hormone issues facing men, but I’m not so sure. Let’s explore what else might be causing the problem.

Read More

3 Ways to Regulate Insulin That Have Nothing to Do with Food

Today’s guest post is served by a good friend of Mark’s Daily Apple, Dr. Sarah Ballantyne, PhD, or as you might know her—The Paleo Mom.  

Regulating blood sugar levels is a key feature of any health-promoting diet [15, 20] . High blood sugar levels after eating are a major stimulator of reactive oxygen species (ROS), which are chemically reactive molecules that have important roles in cell signaling (the complex communication between and within cells) and in homeostasis (maintenance of a stable environment inside and outside the cell). But ROS are also potent signals for inflammation and stimulate the production of proinflammatory cytokines (chemical messengers), and also injure cells and tissue. As a result, chronic high blood sugar levels can cause serious damage throughout the body, including to blood vessels and vital organs. This is why diabetes (chronical hyperglycemia) is associated with higher risk of stroke, cardiovascular disease, vision problems, kidney disease, and nerve damage.

Read More

Dear Mark: High T, More Wives? Plus Testosterone for Women and the Best Primal Roux

For today’s edition of Dear Mark, I’m answering three questions from readers. First, I respond to a reader wondering which direction the arrow of casuality points in the married Swahili man/testosterone level study I discussed last week. Are high testosterone levels in polygamous Swahili men a cause or consequence of having more than one wife? Second, what’s the deal with testosterone in women? Do they need it as much as men do? And last but not least, what’s the best gluten-free, Primal-friendly flour to use for making a roux?

Let’s go:

Read More

10 Tips to Boost Your Serotonin

Serotonin is a major regulator of mood and depression risk. These are important, vital roles, to be sure. Your mood describes how you experience and interpret the world. If it’s consistently bad, you’regoing to have a rough time. Yet, serotonin is much more than the “feel-good hormone.” It also influences sexual desire and helps us remember. It’s the precursor to melatonin, the neurotransmitter that allows us to sleep.

Read More

Join Over 300,000 Subscribers!

Signup and get:

Primal Blueprint Fitness plus 7 other eBooks
7-Day Course on Primal Fundamentals
Special Offers and More!