Tag: dear mark

Dear Mark: Broth, Fasting, Coffee, and Metformin (and More)

For today’s edition of Dear Mark, I’m answering a bunch of questions from comment sections. First, did I get AMPK and mTOR mixed up in a recent post? Yes. Second, I give a warning for those who wish to add ginger to their broth. Third, is it a problem that we can’t accurately measure autophagy? Fourth, how does coffee with coconut oil affect a fast? Fifth, is there a way to make mayonnaise with extra B12 and metformin? Actually, kinda. Sixth, should you feel awkward about proposing hypotheses or presenting scientific evidence to your doctor? No.

Let’s go:

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Dear Mark: Metformin Side Effects, Kraft Heinz Deal Questions

For today’s edition of Dear Mark, I’m answering a few questions from readers. First, the diabetes drug metformin looks like a “wonder” drug, even (or especially) for non-diabetics. Are there any known side effects? Is there anything we should watch out for?

Second, I address some of the concerns and criticisms shared in response to the Kraft Heinz announcement post.

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Dear Mark: Oxidative Priority Follow-up

Last week, Craig Emmerich graced us with a great post on the oxidative priority of various dietary fuel sources, namely fats, carbohydrates, and protein.

If you haven’t had the chance to read through Craig’s post, definitely do. The visuals really drive home the point of fuel priority. Visuals appeal to me. They have a way of sticking with you, and there’s a power in recalling them when you’re making daily choices.

Today, I’m going through and answering some of the questions you folks had in the comment board.

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Dear Mark: Is There No Upper Limit to Endurance Training?

Yesterday, I linked to a study showing that the beneficial effects of high levels of cardiorespiratory fitness—the kind you build with cardio/endurance training, HIIT, and sprints—have no upper limit. At first glance, this study appears to bust the “myth” of chronic cardio and the U-shaped curve of endurance training and prove that the more you train, the longer you’ll live. This appears to run counter to some of my central claims—that too much mid-to-high intensity endurance exercise leads to burnout, health issues, and diminishing returns.

A commenter wrote a great comment that got me wondering:

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Dear Mark: Omega-6 Deficiency and Saw Palmetto

For today’s edition of Dear Mark, I’m answering two questions from readers. First, is it possible to become deficient in omega-6 fats as an adult? What would that even look like, and is there anything that might make omega-6 more important?

Second is a question related to last week’s feature on prostate health. Is saw palmetto an effective supplement for prostate issues? It depends on the issue.

Let’s go:

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Dear Mark: Air-Frying, “Primal” Vegan-ish, Perfect Heath Diet, and Bad Rep or Rap

For today’s edition of Dear Mark, I’m answering four questions. First, is air-frying gentler than deep-frying? Does it produce less acrylamide? Second, what do I think of a reader’s Primal-style plant-based way of eating? It’s actually quite good. Third, why didn’t I mention the Perfect Health Diet in last week’s post on top trending diets? And last, did I make a typo or grammatical error when I wrote “bad rap”?

Let’s find out:

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Dear Mark: PUFA/SFA Swap, Ticks and Meat Allergy, HIIT for Older Men

For today’s edition of Dear Mark, I’m doing three quick topics. First, what are we to make of the studies in which replacing saturated fat and trans-fat with omega-3 and omega-6 polyunsaturated fat seems to reduce heart disease? Second, although red meat is nutrient dense and generally a more interesting option than plain chicken breast, some people have legit red meat allergies (tick-induced or otherwise). What do I think about that and the tick situation in general? And third, is HIIT an effective (and safe) option for middle-aged men?

Let’s go:

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Dear Mark: Diet to Get Lean, Exercise to Get Healthy?

For today’s edition of Dear Mark, I’ll be discussing the role of exercise alone in weight and fat loss. If it seems like I’ve been harping on this same topic for a couple weeks now, it’s only because it’s so important to identify both the mainstream (“You must exercise ten minutes for each Oreo you eat.”) and alternative misconceptions (“Exercise has no effect on body composition.”) about exercise. Exercise—all by itself—actually can help you lose body fat, even if it has less to do with “burning calories” than other factors.

Let’s take a look:

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Dear Mark: Does Physical Activity Affect Obesity Risk?

For today’s edition of Dear Mark, I’m answering one question from a reader. It concerns the effects of physical activity on obesity.

This is an evergreen topic, a constant in the queries I receive. Is exercise necessary for weight loss? Does physical activity improve body weight? Is exercise all about burning calories, or is there something else going on?

Let’s get to it:

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Dear Mark: Pregnenolone

In today’s edition of Dear Mark, I’m talking about pregnenolone, the “master hormone.” Most of the hormones we talk about, like testosterone, estrogen, and cortisol, all have pregnenolone as their precursor hormone. What can happen when pregnenolone goes too low? Can taking pregnenolone solve any problems? Is menopause actually a pregnenolone deficiency?

Let’s find out….

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