Meet Mark

Let me introduce myself. My name is Mark Sisson. I’m 63 years young. I live and work in Malibu, California. In a past life I was a professional marathoner and triathlete. Now my life goal is to help 100 million people get healthy. I started this blog in 2006 to empower people to take full responsibility for their own health and enjoyment of life by investigating, discussing, and critically rethinking everything we’ve assumed to be true about health and wellness...

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Tag: Big Pharma

Dear Mark: Phones in Bedrooms, Antidepressants, Pastured Egg Omega-6 Content

For today’s edition of Dear Mark, I’m answering three questions from readers. I’ve come down hard against phones in bedrooms in the past. Is there a “good way” to use your phone in the bedroom? Reader Kathy offered some good reasons for keeping a phone there; what do I think? Next, HealthyHombre laments having to take antidepressants (but he shouldn’t lament). And finally, I cover the differences in omega-6 between pastured eggs and conventional eggs.

Let’s go:

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6 Older Studies That Got No Love but Should Have

“Back in my day, science came harder. We may not have had your fancy longitudinal data analyzing software, your iterated pool of available data upon which to build, or your worldwide network of instantaneous communication and information transmission, but we rolled up our sleeves and got to work just the same. And man did we do some science and discover some things. Boy, you don’t even know the half of it.”

When I turn my sights back to older research, I realize that a lot of this stuff we “discover” in health and nutrition has already been found, or at least hinted at. Today, I’m going to explore some of my favorite research from years past that, if posted to Science Daily or linked on Twitter today, would get a huge response.

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10 Alternative Therapies for ADD & ADHD

A few months back, I put together an article on alternative therapies for depression. Many readers  showed a lot of interest in some of the emerging non-drug treatments in that field, and, more importantly, many began to relay their own stories about how they overcame or successfully managed their depression through various strategies. That’s what I love the most about this community—sharing experience and expertise in the interest of broadening available solutions beyond what conventional thought tells us.
I’ve received frequent requests over the years to do the same for the convoluted world of ADD and ADHD treatment. There’s a lot to this picture and (if there’s interest) probably fodder for a follow-up post. For today I’ll delve into some of the lifestyle strategies and alternative therapies that offer the most promise.

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Stop Obsessing Over the Numbers

My friend, former co-competitor, business partner, and writing buddy Brad Kearns had been on a “Quantified Self” kick, tracking biomarkers, testing blood sugar and ketone levels, and staying abreast of all the various ways we can quantitatively check our progress. He’s months into a ketogenic experiment and had hoped to marry his subjective impressions to objective measurements to strengthen his intuition and improve his results.

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Dear Mark: HDL, Probiotics for Acne, and Artificial Sweeteneners and Weight Gain

For today’s edition of Dear Mark, I’m answering three questions. First, is HDL all it’s cracked up to be? Is HDL always good? Is it the savior? Or is the story a bit more complicated? Next, what are some good probiotic options for treating acne? Do any exist? And last but not least, what’s the relationship of artificial sweeteners, insulin, appetite, and weight gain?

Let’s go:

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Dear Mark: That New Cholesterol-Lowering Drug Study

For today’s edition of Dear Mark, I’m answering one question. It’s a good one. A reader (many, actually) wrote in to get my opinion on the latest blockbuster cholesterol-lowering drug. A new study appears to show that the drug in question—Repatha—reduced LDL to unprecedented levels and protected patients against the primary cardiovascular disease endpoints they were measuring. What does it all mean? Should we all start taking Repatha?

Let’s dig into it:

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The Emerging Science of Electrostimulation

As a Primal lifer, I recognize that purity has a certain allure, just as I know it has its decided limitations. I frequently find myself wondering, “Would my paleolithic forebears have done/said/eaten that?” and choosing my course of action based on this line of educated assumption. It’s the WWGD lens on modern living. In a Primal-perfect world, that would be sufficient to ensure continued health and happiness. But things don’t always work out as planned…

Let’s say you hurt your back in an unfortunate turn of events. Primal dictates can certainly help with healing you over the long term, but if you want to get out of bed in the morning you’re likely stuck with the doc’s prescriptions. Similar situation if you’ve suffered physical damage to your eyesight, hearing, brain, or any number of your less robust anatomical sectors. Sometimes to get life done, you’ve just got to suck it up and take your meds.

It’s possible, however, that this may soon change. In my recent post on the vagus nerve, I touched upon an emerging curiosity in the medical world: electroceuticals. While still in comparative infancy, electroceuticals may end up revolutionizing a health care model currently dominated by the drug industry.

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5 Common Prescriptions That Should Require Nutritional Counseling

I’m not a drug denier. For the most part, at the base level, pharmaceuticals do what they’re supposed to do. Statins lower cholesterol. Beta-blockers lower blood pressure. Antibiotics kill bacteria. Whether those changes save lives or reverse disease is another question entirely. But we can all agree that pharmaceuticals deserve a place in modern medicine. And even if we don’t, they objectively have a place, and we must acknowledge reality.

We can also agree that many of the most common prescription drugs affect the way we absorb, metabolize, utilize, and excrete vitamins, minerals, and other important health co-factors. People taking them deserve nutritional counseling. This is my quick and dirty attempt to encourage that.

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Psychedelics: A New Medical Frontier?

Long before humans interacted with the numinous through intermediaries and holy books, we experienced it in other ways. All night drumming and dancing sessions, extended fasts, exposure to extreme temperatures, steam lodges, and week-long wilderness forays, and other rituals have all been used to produce visions and transcend normal waking consciousness. There’s even a theory that early Christian baptisms were actually simulated drownings that produced near-death experiences and the direct sensation of being in the presence of a higher power.

But perhaps the oldest, most reliable way to directly experience the divine is through the use of psychedelics.

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Antibiotic Resistance: Are We All Doomed?

The future prospects of antibiotics look grim. Headline after headline proclaims the mounting resistance to antibiotics among pathogenic bacteria and the impending inefficacy of our best drugs to fight them. Antibiotic-resistant “pig MRSA” has been documented moving from pigs to people in several countries, including Denmark and Holland. That same MRSA has also been found in the US, England, and is likely brewing wherever pigs and other animals are intensively raised. And just recently, researchers discovered that MCR-1, the gene responsible for resistance to the “last line of defense” antibiotic—polymixin, the one we use when everything else has failed—is transferable between different strains of E. coli. Formerly relegated to pigs, E. coli and K. pneumoniae bacteria with the MCR-1 mutation have appeared in human subjects in several Chinese hospitals. Transferring the gene between different bacterial species is theoretically harder, but that it’s possible at all has raised alarms in the scientific community.

It’s not just industrial farms and antibiotic overuse causing the resistance. Even the scientists studying the problem and running experiments with antibiotics could very well be promoting antibiotic resistance on a larger scale.

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