Meet Mark

Let me introduce myself. My name is Mark Sisson. I’m 63 years young. I live and work in Malibu, California. In a past life I was a professional marathoner and triathlete. Now my life goal is to help 100 million people get healthy. I started this blog in 2006 to empower people to take full responsibility for their own health and enjoyment of life by investigating, discussing, and critically rethinking everything we’ve assumed to be true about health and wellness...

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Dear Mark: Latest in Gene Expression Research

May 24 2010 - One of my favorite topics, as many of you know, is epigenetics. It’s the burgeoning area of science that has blown apart the traditional nature-nurture dichotomy by examining the lifestyle-induced a...

Environmental Toxins and Gene Expression

December 02 2009 - It’s the heart of the Primal Blueprint: understanding that our lifestyle factors direct influence the expression of our genetic code. While the DNA itself is set, the structure fixed, that’s hardl...

Dear Mark: Gene Expression

April 28 2008 - I received tons of emails from last week’s Gene Expression: Location, Location, Location post. Thanks to everybody for their feedback and questions. In the comment section of last week’s post, Ed ...

Gene Expression: Location, Location, Location

April 24 2008 - Geneticists at North Carolina State University have revealed an interesting lesson in gene expression: where you live can have significant impact on how your genes are expressed. The scientists foc...

Dear Mark: Gene Editing

September 19 2016 - For today's edition of Dear Mark, I'll be addressing the concerns raised in the comment section of last week's CRISPR post. Many of you were rather alarmed at my apparent whole-hearted endorsement and...

CRISPR: What Does Gene Editing Mean for the Future of Primal Living?

September 14 2016 - By now, you've no doubt heard of CRISPR, the latest gene-editing tool sweeping research labs across the globe. It was first discovered in certain strains of bacteria, who use it as an important weap...

The Genetics of Obesity: Are You Destined to Be Fat?

August 30 2016 - The entire premise of the Primal Blueprint is enabling you to be the architect of your health and happiness. If we can identify the environmental triggers and selective pressures under which the human...

What I Mean by “Reprogram Your Genes”

February 20 2010 - From time to time I'll get a comment from a skeptical reader that says something like, "I don’t think it’s possible to reprogram your genes through diet/lifestyle. Of course our genes are set at b...

Forging Your Own Genetic Destiny

January 10 2009 - As you may know, at the core of the Primal Blueprint is gene expression - the idea that our genes can be "switched" on or off, or influenced into producing varying amounts of proteins based on environ...

Control Your Lifestyle, Control Your Genes

June 22 2008 - Results of a dramatic study highlighting (guess what) gene expression were published last week by the National Academy of Sciences, and suddenly the popular media is suddenly paying very close attent...

Dear Mark: Latest in Gene Expression Research

May 24 2010 - One of my favorite topics, as many of you know, is epigenetics. It’s the burgeoning area of science that has blown apart the traditional nature-nurture dichotomy by examining the lifestyle-induced a...

Environmental Toxins and Gene Expression

December 02 2009 - It’s the heart of the Primal Blueprint: understanding that our lifestyle factors direct influence the expression of our genetic code. While the DNA itself is set, the structure fixed, that’s hardl...

What I Mean by “Reprogram Your Genes”

February 20 2010 - From time to time I'll get a comment from a skeptical reader that says something like, "I don’t think it’s possible to reprogram your genes through diet/lifestyle. Of course our genes are set at b...

Control Your Lifestyle, Control Your Genes

June 22 2008 - Results of a dramatic study highlighting (guess what) gene expression were published last week by the National Academy of Sciences, and suddenly the popular media is suddenly paying very close attent...

Dear Mark: What Are the Differences Between Vitamin K2 MK-4 and MK-7?

August 06 2019 - For today's edition of Dear Mark, I'm answering a question about the different forms of vitamin K2. Everyone knows the importance of vitamin K2—at least around these parts—but very few understand ...

Dear Mark: Safe Tick Repellent, Fish Intake on Mediterranean Diet, and Therapeutic Value of Wine

July 30 2019 - For today's edition of Dear Mark, I'm answering a few questions from recent comment boards. First, with all the scary tick-related news coming out lately, are there any non-toxic tick repellents that ...

Is Keto Bad For Cholesterol?

February 13 2019 - We've all heard the story. Maybe we've even been the protagonist. Person goes full keto. They lose a bunch of weight, normalize their pre-diabetic glucose numbers, resolve their high blood pressure...

Dear Mark: How Do the Hadza Eat So Much Honey? and Happy New Year!

January 01 2019 - For today's edition of Dear Mark, I'm answering one eternal question: How do the Hadza tribespeople of Northern Tanzania eat so much honey and maintain their trim figures and pristine metabolic health...

Omega-3 for Health: What the Latest Research Shows

August 02 2018 - It's been a long time since I published the Definitive Guide to Fish Oils. Oh sure, here and there I've cited some research supporting the beneficial effects of fish fat, but it almost goes without...

What Is Paleo?

July 06 2018 - While the paleo diet has grown in popularity the last several years, there's still confusion about what paleo does and doesn't promote. Does "being paleo" mean living as close to our hunter-gatherer f...

Ask the Coach: Primal Health Coaches Answer Your Questions

June 25 2018 - A couple weeks ago I asked for ideas for our Primal Health Coaches—what questions have you ever wanted to ask a Primal Health Coach? Many of you wrote in, and I loved reading your ideas. There were ...

How Long Does It Take for Fitness Benefits to Show?

January 17 2017 - A big reason most people never stick to a serious exercise routine is that the benefits most people are interested in take a while to appear. Fat loss, muscle gain, boosts to strength, speed, and sta...

The Best Kind of Health Insurance

July 29 2015 - I’m not interested in talking about Supreme Court decisions, the Affordable Health Care Act or for-profit versus non-profit business models. No, today I have something else in mind. It’s a perspec...

Dear Mark: Melatonin Supplementation, Overcoming Previous Poor Health, and Is HIIT Too Stressful for Women?

June 22 2015 - For today's edition of Dear Mark, I'm answering three questions from readers. First up, what's the deal, exactly, with melatonin supplementation? Is it harmful? Dangerous? Will it impair our body's o...

Dear Mark: Moonlight and Melatonin, Exercise Non-Responders, and Is Weight Loss Impossible and Unhealthy?

April 06 2015 - For today's edition of Dear Mark, we've got three questions and three answers. First, the full moon sure is pretty and big and bright at night, but can it produce (or reflect, rather) enough light to ...

Will We Ever Accept that Exercise is Often the Best Medicine?

April 03 2014 - For years, experts have known that in mild to moderate cases of depression exercise is as effective (or more effective) a treatment as prescription drugs. Yet, here we are in 2014, with still climbing...

Dear Mark: Garcinia Cambogia, Ultra Pasteurization, Getting Better All the Time, and How Much Walking is Enough

January 13 2014 - For today's edition of Dear Mark, I've got a four-parter for you. First, I address the popular new supplement being touted as a powerful fat-burner: garcinia cambogia. Does it measure up to the hype? ...

17 Reasons to Walk More This Year

January 07 2014 - Even though some of you may be tired of me saying this, it needs saying. I say this a lot because it's important: you need to walk more. In fact, if there's one New Year's resolution I think everyone ...

Should You Get Your Genome Sequenced?

December 18 2012 - Earlier this year, I explored the "evolution" of human dietary requirements in the last 10,000 years by examining some of the SNPs - single nucleotide polymorphisms, or variations in genetic sequences...

Why You Should Lift and Lower Heavy Things

August 09 2012 - This is a guest post from Jonathan Bailor of The Smarter Science of Slim and JonathanBailor.com. “Eccentric training has been shown to produce greater muscle hypertrophy than concentric train...

Gene Expression: Location, Location, Location

April 24 2008 - Geneticists at North Carolina State University have revealed an interesting lesson in gene expression: where you live can have significant impact on how your genes are expressed. The scientists foc...

Ask the Coach: Primal Health Coaches Answer Your Questions

June 25 2018 - A couple weeks ago I asked for ideas for our Primal Health Coaches—what questions have you ever wanted to ask a Primal Health Coach? Many of you wrote in, and I loved reading your ideas. There were ...

Is the Technology in Your Life Working for You or Against You?

June 19 2014 - Some weeks ago, I shared some thoughts on the power of food marketing. I claimed its messages and images are so carefully crafted to pique our interests and to influence our associations with certain ...

Why Personalizing Your Diet and Lifestyle Is the Key to Success

December 31 2013 - This is a guest post from Chris Kresser of ChrisKresser.com and author of the new book Your Personal Paleo Code. Join me, Chris and numerous other presenters and Primal enthusiasts from around the wor...

Are We Pre-Programmed to Be Happy?

July 26 2012 - I think we can all agree that a basic goal in life is the attainment of happiness, that mind state characterized by positive and pleasant thoughts and emotions. But how do we become happy? By definiti...

The Power of Positive Thinking

July 01 2009 - Are you realizing the full potential of your mind? Now, before you recoil in horror from the New Agey guru-lingo that question probably sounded like, bear with me a minute. I was recently thumbing ...

My Self-Experimentation and Transformation

December 02 2008 - Thanks to Richard Nikoley of Free the Animal for this Guest Post! Here is more anecdotal proof that a high fat diet coupled with intermittent fasting can improve body composition. If you're interested...

Nature Tops Nurture? Scientists Wrong Again…

February 08 2008 - They just don't get it. Maybe they never will. Reader Karen was outraged enough to send us a link to a news story on MSNBC that states "Nature tops nurture for heavy kids, study says. Research on t...

My Experience with Exogenous Ketones: Tale and Truth

December 27 2016 - I woke up the morning of the ceremony with butterflies in my stomach. I'd done the necessary prep. I'd abstained from carbs the past week and food the past 24 hours. I'd performed four consecutive ful...

How Expressing Your Emotions—or Not—Affects Your Health

October 13 2016 - A little bird told me the other day that it might not be a bad time to talk about the impact of emotions on our health—particularly our choice to express or not express them. I’ve heard people aro...

Dear Mark: Latest in Gene Expression Research

May 24 2010 - One of my favorite topics, as many of you know, is epigenetics. It’s the burgeoning area of science that has blown apart the traditional nature-nurture dichotomy by examining the lifestyle-induced a...

Environmental Toxins and Gene Expression

December 02 2009 - It’s the heart of the Primal Blueprint: understanding that our lifestyle factors direct influence the expression of our genetic code. While the DNA itself is set, the structure fixed, that’s hardl...

Dear Mark: Gene Expression

April 28 2008 - I received tons of emails from last week’s Gene Expression: Location, Location, Location post. Thanks to everybody for their feedback and questions. In the comment section of last week’s post, Ed ...

Dear Mark: Gene Editing

September 19 2016 - For today's edition of Dear Mark, I'll be addressing the concerns raised in the comment section of last week's CRISPR post. Many of you were rather alarmed at my apparent whole-hearted endorsement and...

CRISPR: What Does Gene Editing Mean for the Future of Primal Living?

September 14 2016 - By now, you've no doubt heard of CRISPR, the latest gene-editing tool sweeping research labs across the globe. It was first discovered in certain strains of bacteria, who use it as an important weap...

What I Mean by “Reprogram Your Genes”

February 20 2010 - From time to time I'll get a comment from a skeptical reader that says something like, "I don’t think it’s possible to reprogram your genes through diet/lifestyle. Of course our genes are set at b...

Forging Your Own Genetic Destiny

January 10 2009 - As you may know, at the core of the Primal Blueprint is gene expression - the idea that our genes can be "switched" on or off, or influenced into producing varying amounts of proteins based on environ...

Control Your Lifestyle, Control Your Genes

June 22 2008 - Results of a dramatic study highlighting (guess what) gene expression were published last week by the National Academy of Sciences, and suddenly the popular media is suddenly paying very close attent...

Epigenetics and Depression

May 20 2008 - We just can’t help it. This epigenetics stuff really floats our boat. The last few weeks we’ve brought you a Dear Mark primer on gene expression as well as news on recent studies examining the rol...

Dear Mark: Safe Tick Repellent, Fish Intake on Mediterranean Diet, and Therapeutic Value of Wine

July 30 2019 - For today's edition of Dear Mark, I'm answering a few questions from recent comment boards. First, with all the scary tick-related news coming out lately, are there any non-toxic tick repellents that ...

I Feel Unstoppable

October 12 2018 - It's Friday, everyone! And that means another Primal Blueprint Real Life Story from a Mark's Daily Apple reader. If you have your own success story and would like to share it with me and the Mark's Da...

Health Coaches Find Success with the Primal Blueprint Certification Program

December 12 2014 - It’s Friday, everyone! And that means another Primal Blueprint Real Life Story from a Mark's Daily Apple reader. If you have your own success story and would like to share it with me and the Mark’...

Primal Blueprint Success Story

March 18 2008 - I got this message from a reader who has been following our site for some time and decided to incorporate my Primal Blueprint ® lifestyle tactics into his life. Photos, results and advice follow... ...

I Now Have Plans All the Way to Ninety

March 24 2017 - It’s Friday, everyone! And that means another Primal Blueprint Real Life Story from a Mark's Daily Apple reader. If you have your own success story and would like to share it with me and the Mark’...

Seven Years Primal: Healthier, Stronger, and Wiser Than Ever

September 30 2016 - It’s Friday, everyone! And that means another Primal Blueprint Real Life Story from a Mark's Daily Apple reader. If you have your own success story and would like to share it with me and the Mark’...

From Overtraining to Success with Primal Blueprint Fitness

December 26 2014 - It’s Friday, everyone! And that means another Primal Blueprint Real Life Story from a Mark's Daily Apple reader. If you have your own success story and would like to share it with me and the Mark’...

I Was Unhealthy and Getting Sicker: Something Had to Change

July 12 2013 - It’s Friday, everyone! And that means another Primal Blueprint Real Life Story from a Mark's Daily Apple reader. If you have your own success story and would like to share it with me and the Mark’...

Where Are They Now? – Round 2

April 16 2010 - What is in a story about personal health and wellness? We all have them; every one of us. Yours might be about your relationship with food, or about your body image, or about weight loss, or about ove...

The Genetics of Obesity: Are You Destined to Be Fat?

August 30 2016 - The entire premise of the Primal Blueprint is enabling you to be the architect of your health and happiness. If we can identify the environmental triggers and selective pressures under which the human...

Dear Mark: Moonlight and Melatonin, Exercise Non-Responders, and Is Weight Loss Impossible and Unhealthy?

April 06 2015 - For today's edition of Dear Mark, we've got three questions and three answers. First, the full moon sure is pretty and big and bright at night, but can it produce (or reflect, rather) enough light to ...

Dear Mark: Peripheral Neuropathy, Primal Compromises for Love, and Carbs in Ketosis

March 02 2015 - For this week's edition of Dear Mark, I'm answering three questions. First up, what could be causing a reader's peripheral neuropathy? Could it be gluten, B12 and/or B6 deficiency, diabetes, or inadeq...

The Primal Blueprint 8 Key Concepts

September 12 2012 - With the Primal Blueprint 21-Day Challenge having just begun, it's the perfect time to go over the Primal Blueprint 8 Key Concepts. I believe that fully grokking these powerful ideas is crucial to suc...

What Does It Mean to Be Fat-Adapted?

July 04 2012 - When describing someone that has successfully made the transition to the Primal way of eating I often refer to them as "fat-adapted" or as "fat-burning beasts". But what exactly does it mean to be "fa...

Does a High-Fat Diet Cause Type 2 Diabetes?

August 24 2011 - This is a special guest post from Denise Minger (thank you, Denise!). When fear-inducing news headlines hit the papers (and airwaves and iPads...) -  High-Fat Diet Linked to Breast Cancer, Eating Who...

Did a Wrinkle in Human Evolution Predispose Us to Diabetes?

February 28 2011 - A new mice-with-an-engineered-human-genetic-deficiency study is out that promises to shed light on why humans are so darn diabetic and obese - and the cause is an evolutionary "mistake." A deficiency ...

The Myriad Benefits of Intermittent Fasting

February 16 2011 - Calorie restriction is all the rage in anti-aging circles. A few mice and worm studies seem to show that drastic reductions in food intake over a long period of time have the effect of prolonging life...

Dear Mark: The Low Carb Flu

June 07 2010 - Conquering carbs offers a whole constellation of rewards, not the least of which is a steady, brisk energy unlike most people have known before (well, maybe since the whirling age of 10 or so…). Peo...

17 Reasons You’re Not Losing Weight

January 26 2010 - Effective, healthy weight loss isn’t only due to the simplistic calories in, calories out paradigm. Nor is it solely reliant on diet and exercise. It’s everything – it’s all the various signal...

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