December 02 2009 - It’s the heart of the Primal Blueprint: understanding that our lifestyle factors direct influence the expression of our genetic code. While the DNA itself is set, the structure fixed, that’s hardl...
April 28 2008 - I received tons of emails from last week’s Gene Expression: Location, Location, Location post. Thanks to everybody for their feedback and questions. In the comment section of last week’s post, Ed ...
April 24 2008 - Geneticists at North Carolina State University have revealed an interesting lesson in gene expression: where you live can have significant impact on how your genes are expressed. The scientists foc...
May 24 2010 - One of my favorite topics, as many of you know, is epigenetics. It’s the burgeoning area of science that has blown apart the traditional nature-nurture dichotomy by examining the lifestyle-induced a...
January 10 2009 - As you may know, at the core of the Primal Blueprint is gene expression - the idea that our genes can be "switched" on or off, or influenced into producing varying amounts of proteins based on environ...
May 10 2008 - Yes, it’s oh-so-middle-school, but we called it! Following the first ever metabolome-wide association study conducted across four countries, researchers are affirming the promise of metabolic finger...
August 15 2013 - On September 11, 2001, passenger jets struck the Twin Towers, leveling them, killing thousands of New Yorkers, and traumatizing tens of thousands more. Among those directly affected, but not killed, b...
January 04 2012 - A hallmark of the Primal Blueprint is that our genetics were shaped by our ancestral environment. That the foods to which we had access, the amount of sun and stress and sleep to which our bodies beca...
July 23 2008 - In the last few months we've been highlighting new research that illustrates the power of individuals to influence their genetic expression through basic lifestyle choices, whether through diet, exerc...
October 25 2012 - You hear a lot about type 2 diabetes on this and other sites in the community. It's easy to see why: type 2 diabetes is the "lifestyle" diabetes, the preventable one, the one that "doesn't have to hap...
December 02 2009 - It’s the heart of the Primal Blueprint: understanding that our lifestyle factors direct influence the expression of our genetic code. While the DNA itself is set, the structure fixed, that’s hardl...
May 24 2010 - One of my favorite topics, as many of you know, is epigenetics. It’s the burgeoning area of science that has blown apart the traditional nature-nurture dichotomy by examining the lifestyle-induced a...
August 15 2013 - On September 11, 2001, passenger jets struck the Twin Towers, leveling them, killing thousands of New Yorkers, and traumatizing tens of thousands more. Among those directly affected, but not killed, b...
January 04 2012 - A hallmark of the Primal Blueprint is that our genetics were shaped by our ancestral environment. That the foods to which we had access, the amount of sun and stress and sleep to which our bodies beca...
October 25 2012 - You hear a lot about type 2 diabetes on this and other sites in the community. It's easy to see why: type 2 diabetes is the "lifestyle" diabetes, the preventable one, the one that "doesn't have to hap...
May 19 2021 - Everyone understands the intuitive power of eating the way our hunter-gatherer ancestors ate for hundreds of thousands of years. Sure, there's a lot of variation throughout the eons. Changing climates...
February 24 2015 - Last month, I received an unexpected email request from a man named Craig Pickering: “Send me your saliva.” Craig works for DNAFit, a genetic testing company using customers’ DNA results to o...
October 26 2011 - I receive a lot of emails from folks worried about losing too much weight on the Primal Blueprint, underweight readers who need to gain weight, or the formerly overweight who have reached their target...
October 20 2011 - In Monday's "Dear Mark" post, I briefly outlined a few of the benefits to having healthy, abundant mitochondria, and in the past, I've alluded to the damaging effects of statins on mitochondrial funct...
February 28 2011 - A new mice-with-an-engineered-human-genetic-deficiency study is out that promises to shed light on why humans are so darn diabetic and obese - and the cause is an evolutionary "mistake." A deficiency ...
February 24 2015 - Last month, I received an unexpected email request from a man named Craig Pickering: “Send me your saliva.” Craig works for DNAFit, a genetic testing company using customers’ DNA results to o...
November 01 2011 - A couple weeks ago, I wrote about how becoming an efficient fat-burner helps mitochondrial function, and last week I went over some of the nutrients and supplements most important for your mitochondri...
December 18 2012 - Earlier this year, I explored the "evolution" of human dietary requirements in the last 10,000 years by examining some of the SNPs - single nucleotide polymorphisms, or variations in genetic sequences...
February 16 2008 - A research study out this week indicates type II muscle mass associated with strength training not only helps reduce body fat but alters overall metabolism. Researchers from the Boston University Sch...
August 20 2010 - You love the runner’s high, chiseled physique, steady energy, knock-out sleep, and that alluring post-workout glow. And, sure, there’s always the extraordinary cardiovascular benefit, cancer deter...
March 30 2016 - As I mentioned earlier this year, our personal ancestry can help determine how we respond to certain dietary, behavior, exercise, and lifestyle patterns. The big question remaining is this: does going...
September 11 2008 - In a new study out of the Archives of Internal Medicine investigators discovered that even people with extra copies of the “fat mass and obesity” genes called FTO did NOT get fatter if they were a...
January 17 2017 - A big reason most people never stick to a serious exercise routine is that the benefits most people are interested in take a while to appear. Fat loss, muscle gain, boosts to strength, speed, and sta...
January 07 2014 - Even though some of you may be tired of me saying this, it needs saying. I say this a lot because it's important: you need to walk more. In fact, if there's one simple health intervention I think ever...
August 04 2009 - So, you've decided to take up the challenge to go Primal or Primal-keto. Now what? First things first. You have to know the basics. If you're new to the Primal Blueprint the following article will be ...
April 24 2008 - Geneticists at North Carolina State University have revealed an interesting lesson in gene expression: where you live can have significant impact on how your genes are expressed. The scientists foc...
November 11 2015 - You read Mark's Daily Apple every day. Paleo health, nutrition, and fitness folks populate your Twitter feed almost exclusively. You've got several PubMed alerts set up, helping you stay on top of the...
July 26 2012 - I think we can all agree that a basic goal in life is the attainment of happiness, that mind state characterized by positive and pleasant thoughts and emotions. But how do we become happy? By definiti...
February 08 2008 - They just don't get it. Maybe they never will. Reader Karen was outraged enough to send us a link to a news story on MSNBC that states "Nature tops nurture for heavy kids, study says. Research on t...
March 27 2012 - A time-honored and research-tested way to extend an animal's lifespan is to restrict its caloric intake. Studies repeatedly confirm that if, say, a lab mouse normally gets two full bowls of lab chow a...
July 01 2020 - You can't change your genes. But you can program them. The modern world presents a number of problems for our genes. The world we've constructed over the last 50 years is not the environment in whi...
November 14 2019 - For today's edition of Dear Mark, I'm answering a bunch of questions from readers. The first one concerns another inflammatory marker, homocysteine. How could CRP be low but homocysteine be high? What...
May 10 2012 - If you ask most people, they'll pretty much agree that optimism is better than pessimism. Oh, you might get one or two who laugh at the cockeyed optimists and their naivete about the world and its har...
August 06 2009 - Reboot, renew, repair, revitalize? What goals went into your decision to join the Primal Challenge this month? (If you’re on the fence, what vision or particular aspirations pull you toward giving i...
July 01 2009 - Are you realizing the full potential of your mind? Now, before you recoil in horror from the New Agey guru-lingo that question probably sounded like, bear with me a minute. I was recently thumbing ...
December 02 2009 - It’s the heart of the Primal Blueprint: understanding that our lifestyle factors direct influence the expression of our genetic code. While the DNA itself is set, the structure fixed, that’s hardl...
April 28 2008 - I received tons of emails from last week’s Gene Expression: Location, Location, Location post. Thanks to everybody for their feedback and questions. In the comment section of last week’s post, Ed ...
May 24 2010 - One of my favorite topics, as many of you know, is epigenetics. It’s the burgeoning area of science that has blown apart the traditional nature-nurture dichotomy by examining the lifestyle-induced a...
January 10 2009 - As you may know, at the core of the Primal Blueprint is gene expression - the idea that our genes can be "switched" on or off, or influenced into producing varying amounts of proteins based on environ...
May 10 2008 - Yes, it’s oh-so-middle-school, but we called it! Following the first ever metabolome-wide association study conducted across four countries, researchers are affirming the promise of metabolic finger...
July 23 2008 - In the last few months we've been highlighting new research that illustrates the power of individuals to influence their genetic expression through basic lifestyle choices, whether through diet, exerc...
October 25 2012 - You hear a lot about type 2 diabetes on this and other sites in the community. It's easy to see why: type 2 diabetes is the "lifestyle" diabetes, the preventable one, the one that "doesn't have to hap...
May 19 2021 - Everyone understands the intuitive power of eating the way our hunter-gatherer ancestors ate for hundreds of thousands of years. Sure, there's a lot of variation throughout the eons. Changing climates...
July 26 2012 - I think we can all agree that a basic goal in life is the attainment of happiness, that mind state characterized by positive and pleasant thoughts and emotions. But how do we become happy? By definiti...
March 29 2012 - A couple weeks back, the LA Times published a piece on a geneticist's experience with "personalized medicine." Based on careful and constant monitoring of his sequenced DNA and around 40,000 health ma...
August 09 2017 - Normally, I'm deep in the thick of nutritional research or other heady topics midweek. Today, not so much. I have coffee on the brain after trying a few new concoctions recently. As I've noted in the ...
July 12 2014 - Get a head start on your daily intake of nutrient dense leafy greens by eating a serving first thing in the morning. Maybe salad isn’t exactly what you want to pair with your morning cup of coffee, ...
November 10 2019 - Thanksgiving is only a couple weeks away and in the United States this means one thing: turkey. Few other foods seem to dominate a holiday like this bird with a mind-boggling demand of 45+ million tur...
May 20 2017 - Lomo Saltado turns an Asian stir-fry into a uniquely Peruvian meal. The recipe starts out in familiar stir-fry territory: thinly sliced steak cook with red onion, soy sauce and vinegar. But then tomat...
April 15 2017 - Today's guest recipe is served up by a good friend to Mark's Daily Apple—Maria Emmerich, well-known author and health blogger. I grew up overweight and unhealthy. I love food and I will always l...
September 24 2016 - I'm Melissa Joulwan, but you can call me Mel. I have a killer recipe for you today. But first, I'll tell you a little about myself. I'm the author of the paleo cookbooks Well Fed, Well Fed 2, and the ...
January 30 2009 - Cold weather has a way of encouraging comfort food eating, and partaking in traditional comfort foods typically means derailing your healthy eating plan with carbs, carbs and more carbs. Fortunately, ...
June 27 2009 - Yesterday we brought you Scallops and Bacon from a brand new Worker Bee. Today new Worker Bee #2 has another delicious Primal recipe. Enjoy! __________________________ There is something to be sai...
January 22 2011 - Tart, sour, acidic, harsh: four words that don’t exactly make our mouth water. Unfortunately, they’re often words that come to mind when tasting moderately-priced red wine vinegar that we’ve bou...
May 08 2021 - Crisp and caramelized on the outside, but never burnt. A first bite that melts in your mouth as the savory, perfectly seasoned flavor of beef hits your palate. The rich, smoky aroma of animal fat drip...
March 18 2008 - I got this message from a reader who has been following our site for some time and decided to incorporate my Primal Blueprint ® lifestyle tactics into his life. Photos, results and advice follow... ...
March 02 2020 - If you have your own success story and would like to share it with me and the Mark’s Daily Apple community please contact me here. I’ll continue to publish these as long as they keep coming in. T...
October 12 2018 - It's Friday, everyone! And that means another Primal Blueprint Real Life Story from a Mark's Daily Apple reader. If you have your own success story and would like to share it with me and the Mark's Da...
December 12 2014 - It’s Friday, everyone! And that means another Primal Blueprint Real Life Story from a Mark's Daily Apple reader. If you have your own success story and would like to share it with me and the Mark’...
June 16 2017 - It’s Friday, everyone! And that means another Primal Blueprint Real Life Story from a Mark's Daily Apple reader. If you have your own success story and would like to share it with me and the Mark’...
October 02 2015 -
October 30 2015 -
June 12 2009 - For anyone that is now familiar with The Primal Blueprint, you'll recognize both of the characters to the right. It's our lovable Primal role model, Grok, and his modern antithesis - your average over...
July 12 2013 - It’s Friday, everyone! And that means another Primal Blueprint Real Life Story from a Mark's Daily Apple reader. If you have your own success story and would like to share it with me and the Mark’...
March 24 2017 - It’s Friday, everyone! And that means another Primal Blueprint Real Life Story from a Mark's Daily Apple reader. If you have your own success story and would like to share it with me and the Mark’...
October 26 2011 - I receive a lot of emails from folks worried about losing too much weight on the Primal Blueprint, underweight readers who need to gain weight, or the formerly overweight who have reached their target...
February 28 2011 - A new mice-with-an-engineered-human-genetic-deficiency study is out that promises to shed light on why humans are so darn diabetic and obese - and the cause is an evolutionary "mistake." A deficiency ...
January 12 2011 - The following are both actual and paraphrased versions of questions I regularly get from readers: If grains are so bad how can you explain the leanness and good health of Clarence Bass? How is i...
September 12 2012 - With the Primal Blueprint 21-Day Challenge having just begun, it's the perfect time to go over the Primal Blueprint 8 Key Concepts. I believe that fully grokking these powerful ideas is crucial to suc...
February 16 2008 - A research study out this week indicates type II muscle mass associated with strength training not only helps reduce body fat but alters overall metabolism. Researchers from the Boston University Sch...
March 27 2012 - A time-honored and research-tested way to extend an animal's lifespan is to restrict its caloric intake. Studies repeatedly confirm that if, say, a lab mouse normally gets two full bowls of lab chow a...
July 16 2008 -
August 30 2016 - The entire premise of the Primal Blueprint is enabling you to be the architect of your health and happiness. If we can identify the environmental triggers and selective pressures under which the human...
January 06 2016 - Go back 160,000 years and we all share a common ancestor: The emergence of the first Homo sapiens in East Africa. Since then, humans have spread across every environment imaginable and adapted to tho...
January 06 2009 - A soon-to-be published study in Appetite [2009 Feb;52(1):96-103] (but apparently already published online earlier this summer) done by a group at Tufts seems to have "proven" that when you remove carb...
Ⓒ 2023 Mark's Daily Apple
