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Dear Mark: Gene Expression

April 28 2008 - I received tons of emails from last week’s Gene Expression: Location, Location, Location post. Thanks to everybody for their feedback and questions. In the comment section of last week’s post, Ed ...

Environmental Toxins and Gene Expression

December 02 2009 - It’s the heart of the Primal Blueprint: understanding that our lifestyle factors direct influence the expression of our genetic code. While the DNA itself is set, the structure fixed, that’s hardl...

Gene Expression: Location, Location, Location

April 24 2008 - Geneticists at North Carolina State University have revealed an interesting lesson in gene expression: where you live can have significant impact on how your genes are expressed. The scientists foc...

Dear Mark: Latest in Gene Expression Research

May 24 2010 - One of my favorite topics, as many of you know, is epigenetics. It’s the burgeoning area of science that has blown apart the traditional nature-nurture dichotomy by examining the lifestyle-induced a...

What If I Don’t Want to Lose Weight?

October 26 2011 - I receive a lot of emails from folks worried about losing too much weight on the Primal Blueprint, underweight readers who need to gain weight, or the formerly overweight who have reached their target...

Managing Your Mitochondria

October 20 2011 - In Monday's "Dear Mark" post, I briefly outlined a few of the benefits to having healthy, abundant mitochondria, and in the past, I've alluded to the damaging effects of statins on mitochondrial funct...

Are We Pre-Programmed to Be Happy?

July 26 2012 - I think we can all agree that a basic goal in life is the attainment of happiness, that mind state characterized by positive and pleasant thoughts and emotions. But how do we become happy? By definiti...

Forging Your Own Genetic Destiny

January 10 2009 - As you may know, at the core of the Primal Blueprint is gene expression - the idea that our genes can be "switched" on or off, or influenced into producing varying amounts of proteins based on environ...

Metabolic Fingerprinting

May 10 2008 - Yes, it’s oh-so-middle-school, but we called it! Following the first ever metabolome-wide association study conducted across four countries, researchers are affirming the promise of metabolic finger...

Relaxation Response

July 23 2008 - In the last few months we've been highlighting new research that illustrates the power of individuals to influence their genetic expression through basic lifestyle choices, whether through diet, exerc...

Environmental Toxins and Gene Expression

December 02 2009 - It’s the heart of the Primal Blueprint: understanding that our lifestyle factors direct influence the expression of our genetic code. While the DNA itself is set, the structure fixed, that’s hardl...

Dear Mark: Latest in Gene Expression Research

May 24 2010 - One of my favorite topics, as many of you know, is epigenetics. It’s the burgeoning area of science that has blown apart the traditional nature-nurture dichotomy by examining the lifestyle-induced a...

What If I Don’t Want to Lose Weight?

October 26 2011 - I receive a lot of emails from folks worried about losing too much weight on the Primal Blueprint, underweight readers who need to gain weight, or the formerly overweight who have reached their target...

Managing Your Mitochondria

October 20 2011 - In Monday's "Dear Mark" post, I briefly outlined a few of the benefits to having healthy, abundant mitochondria, and in the past, I've alluded to the damaging effects of statins on mitochondrial funct...

Control Your Lifestyle, Control Your Genes

June 22 2008 - Results of a dramatic study highlighting (guess what) gene expression were published last week by the National Academy of Sciences, and suddenly the popular media is suddenly paying very close attent...

Gotta Love That Genome

January 28 2008 - Cool news for your Monday - Researchers from Duke University have discovered a way to examine the entire genome and find the "unpackaged" centers that direct gene expression: A new resource that iden...

You Are What Your Mother and Father (and Grandmothers and Grandfathers) Ate

August 15 2013 - On September 11, 2001, passenger jets struck the Twin Towers, leveling them, killing thousands of New Yorkers, and traumatizing tens of thousands more. Among those directly affected, but not killed, b...

What I Mean by “Reprogram Your Genes”

February 20 2010 - From time to time I'll get a comment from a skeptical reader that says something like, "I don’t think it’s possible to reprogram your genes through diet/lifestyle. Of course our genes are set at b...

Should You Get Your Genome Sequenced?

December 18 2012 - Earlier this year, I explored the "evolution" of human dietary requirements in the last 10,000 years by examining some of the SNPs - single nucleotide polymorphisms, or variations in genetic sequences...

Did a Wrinkle in Human Evolution Predispose Us to Diabetes?

February 28 2011 - A new mice-with-an-engineered-human-genetic-deficiency study is out that promises to shed light on why humans are so darn diabetic and obese - and the cause is an evolutionary "mistake." A deficiency ...

Should You Get Your Genome Sequenced?

December 18 2012 - Earlier this year, I explored the "evolution" of human dietary requirements in the last 10,000 years by examining some of the SNPs - single nucleotide polymorphisms, or variations in genetic sequences...

Managing Your Mitochondria: Exercise

November 01 2011 - A couple weeks ago, I wrote about how becoming an efficient fat-burner helps mitochondrial function, and last week I went over some of the nutrients and supplements most important for your mitochondri...

Can Getting Your DNA Tested Help You Optimize Your Diet and Training?

February 24 2015 - Last month, I received an unexpected email request from a man named Craig Pickering: “Send me your saliva.” Craig works for DNAFit, a genetic testing company using customers’ DNA results to o...

Magnificent Muscle

February 16 2008 - A research study out this week indicates type II muscle mass associated with strength training not only helps reduce body fat but alters overall metabolism. Researchers from the Boston University Sch...

New Study: Exercise is Good and Lowers Obesity

September 11 2008 - In a new study out of the Archives of Internal Medicine investigators discovered that even people with extra copies of the “fat mass and obesity” genes called FTO did NOT get fatter if they were a...

The Fit Brain

August 20 2010 - You love the runner’s high, chiseled physique, steady energy, knock-out sleep, and that alluring post-workout glow. And, sure, there’s always the extraordinary cardiovascular benefit, cancer deter...

Workout in a Pill?

August 30 2008 - As you probably already know, we here at MDA are all about making informed decisions that produce the best results with a minimal amount of effort. For example, what's the point in running yourself to...

How Going Primal Can Help With 5 Common Genetic Mutations

March 30 2016 - As I mentioned earlier this year, our personal ancestry can help determine how we respond to certain dietary, behavior, exercise, and lifestyle patterns. The big question remaining is this: does going...

17 Reasons to Walk More This Year

January 07 2014 - Even though some of you may be tired of me saying this, it needs saying. I say this a lot because it's important: you need to walk more. In fact, if there's one New Year's resolution I think everyone ...

How Long Does It Take for Fitness Benefits to Show?

January 17 2017 - A big reason most people never stick to a serious exercise routine is that the benefits most people are interested in take a while to appear. Fat loss, muscle gain, boosts to strength, speed, and sta...

Gene Expression: Location, Location, Location

April 24 2008 - Geneticists at North Carolina State University have revealed an interesting lesson in gene expression: where you live can have significant impact on how your genes are expressed. The scientists foc...

Are We Pre-Programmed to Be Happy?

July 26 2012 - I think we can all agree that a basic goal in life is the attainment of happiness, that mind state characterized by positive and pleasant thoughts and emotions. But how do we become happy? By definiti...

Blindspots Even Informed Paleo Enthusiasts Often Have

November 11 2015 - You read Mark's Daily Apple every day. Paleo health, nutrition, and fitness folks populate your Twitter feed almost exclusively. You've got several PubMed alerts set up, helping you stay on top of the...

Nature Tops Nurture? Scientists Wrong Again…

February 08 2008 - They just don't get it. Maybe they never will. Reader Karen was outraged enough to send us a link to a news story on MSNBC that states "Nature tops nurture for heavy kids, study says. Research on t...

Are Humans Hard-Wired to Be Optimistic?

May 10 2012 - If you ask most people, they'll pretty much agree that optimism is better than pessimism. Oh, you might get one or two who laugh at the cockeyed optimists and their naivete about the world and its har...

Why Fast? Part Three – Longevity

March 27 2012 - A time-honored and research-tested way to extend an animal's lifespan is to restrict its caloric intake. Studies repeatedly confirm that if, say, a lab mouse normally gets two full bowls of lab chow a...

Reprogramming Your Genes Starts with Reprogramming Your Mind

August 06 2009 - Reboot, renew, repair, revitalize? What goals went into your decision to join the Primal Challenge this month? (If you’re on the fence, what vision or particular aspirations pull you toward giving i...

Why Personalizing Your Diet and Lifestyle Is the Key to Success

December 31 2013 - This is a guest post from Chris Kresser of ChrisKresser.com and author of the new book Your Personal Paleo Code. Join me, Chris and numerous other presenters and Primal enthusiasts from around the wor...

The Power of Positive Thinking

July 01 2009 - Are you realizing the full potential of your mind? Now, before you recoil in horror from the New Agey guru-lingo that question probably sounded like, bear with me a minute. I was recently thumbing ...

10 Real-Life Reasons Why the Primal Blueprint Works for Me

February 09 2010 - There’s been a lot more talk in the mainstream recently about “caveman” diets and barefoot training. Primal/Paleo/Evo seems to be gaining in popularity and may be nearing the critical mass neede...

Dear Mark: Gene Expression

April 28 2008 - I received tons of emails from last week’s Gene Expression: Location, Location, Location post. Thanks to everybody for their feedback and questions. In the comment section of last week’s post, Ed ...

Environmental Toxins and Gene Expression

December 02 2009 - It’s the heart of the Primal Blueprint: understanding that our lifestyle factors direct influence the expression of our genetic code. While the DNA itself is set, the structure fixed, that’s hardl...

Dear Mark: Latest in Gene Expression Research

May 24 2010 - One of my favorite topics, as many of you know, is epigenetics. It’s the burgeoning area of science that has blown apart the traditional nature-nurture dichotomy by examining the lifestyle-induced a...

Are We Pre-Programmed to Be Happy?

July 26 2012 - I think we can all agree that a basic goal in life is the attainment of happiness, that mind state characterized by positive and pleasant thoughts and emotions. But how do we become happy? By definiti...

Forging Your Own Genetic Destiny

January 10 2009 - As you may know, at the core of the Primal Blueprint is gene expression - the idea that our genes can be "switched" on or off, or influenced into producing varying amounts of proteins based on environ...

Metabolic Fingerprinting

May 10 2008 - Yes, it’s oh-so-middle-school, but we called it! Following the first ever metabolome-wide association study conducted across four countries, researchers are affirming the promise of metabolic finger...

Relaxation Response

July 23 2008 - In the last few months we've been highlighting new research that illustrates the power of individuals to influence their genetic expression through basic lifestyle choices, whether through diet, exerc...

Control Your Lifestyle, Control Your Genes

June 22 2008 - Results of a dramatic study highlighting (guess what) gene expression were published last week by the National Academy of Sciences, and suddenly the popular media is suddenly paying very close attent...

Gotta Love That Genome

January 28 2008 - Cool news for your Monday - Researchers from Duke University have discovered a way to examine the entire genome and find the "unpackaged" centers that direct gene expression: A new resource that iden...

What I Mean by “Reprogram Your Genes”

February 20 2010 - From time to time I'll get a comment from a skeptical reader that says something like, "I don’t think it’s possible to reprogram your genes through diet/lifestyle. Of course our genes are set at b...

Tomato Garlic Mussels

October 09 2010 - After over a month of Primal Challenge festivities it feels good to get back in the kitchen and cook up some Primal fare for the regular weekend recipe post here at MDA. This and next week's recipe wi...

Sunflower Sesame Crackers with Shrimp Paté

February 06 2010 - In last week’s exploration of Primal Snacks we delved into the world of non-potato chips. This week, it seemed fitting to explore non-cracker crackers. Although saying these Sunflower Sesame Cracker...

Crispy Carnitas

January 05 2013 - As if slow-cooked, tender, succulent pork wasn’t tempting enough, carnitas takes it one step further by caramelizing the pork in its own fat until the outside is perfectly browned and crisp. The cri...

Baked Eggs with Creamy Spinach

July 12 2014 - Get a head start on your daily intake of nutrient dense leafy greens by eating a serving first thing in the morning. Maybe salad isn’t exactly what you want to pair with your morning cup of coffee, ...

Paleo Pancakes Two Ways

January 17 2015 - Hey, primal pals. Leslie Klenke here! You may know me from Primal Blueprint Publishing's 2014 release Paleo Girl, my MDA Success Story, the Primal Blueprint Certified Expert Directory, or maybe you to...

Shakshuka (Eggs Poached in Spicy Tomato Sauce)

September 01 2012 - Whether you’re looking for a new breakfast idea or are fond of serving breakfast for dinner, shakshuka fits the bill. Instead of calling the dish shakshuka you can also just call it “Eggs Poached ...

Spicy Buffalo Chicken

September 10 2011 - Who doesn’t love to gnaw on a spicy chicken wing or drummette, every bite a glorious combination of fat and meat that coats your lips with a red, buttery gloss. Diving into a plate of wings or drumm...

Heritage Turkey and Mashed Parsnips

November 10 2019 - Thanksgiving is only a couple weeks away and in the United States this means one thing: turkey. Few other foods seem to dominate a holiday like this bird with a mind-boggling demand of 45+ million tur...

The Allure of Crock Pots

April 15 2009 - I recently received an email from a reader: Mark, First of all, I have enjoyed getting to know more about the Primal Blueprint and I have found it to be very useful. Perhaps you have addressed t...

Chinese Five Spice Pork Chops with Sautéed Escarole

March 30 2013 - Escarole is mostly thought of as a salad green, but like most greens, it’s capable of so much more than that. In this recipe, a hint of vinegar, a pat of butter and a scant drizzle of maple syrup tu...

Primal Blueprint Success Story

March 18 2008 - I got this message from a reader who has been following our site for some time and decided to incorporate my Primal Blueprint ® lifestyle tactics into his life. Photos, results and advice follow... ...

I Feel Unstoppable

October 12 2018 - It's Friday, everyone! And that means another Primal Blueprint Real Life Story from a Mark's Daily Apple reader. If you have your own success story and would like to share it with me and the Mark's Da...

This Is Not a Story of Weight Loss, but of Health

June 16 2017 - It’s Friday, everyone! And that means another Primal Blueprint Real Life Story from a Mark's Daily Apple reader. If you have your own success story and would like to share it with me and the Mark’...

Health Coaches Find Success with the Primal Blueprint Certification Program

December 12 2014 - It’s Friday, everyone! And that means another Primal Blueprint Real Life Story from a Mark's Daily Apple reader. If you have your own success story and would like to share it with me and the Mark’...

A Backpacker’s Journey From Weight Loss To a New Life Mission

July 27 2018 - It's Friday, everyone! And that means another Primal Blueprint Real Life Story from a Mark's Daily Apple reader. If you have your own success story and would like to share it with me and the Mark's Da...

I Was Unhealthy and Getting Sicker: Something Had to Change

July 12 2013 - It’s Friday, everyone! And that means another Primal Blueprint Real Life Story from a Mark's Daily Apple reader. If you have your own success story and would like to share it with me and the Mark’...

Where’s Timothy Now?

December 14 2012 - Who's Timothy, you ask? Timothy is a fellow that submitted a Primal Blueprint Real Life Story a few years back. He's also a PrimalCon veteran (we've been lucky enough to have him and his family atten...

The Quest For a Good Life

July 06 2018 - It's Friday, everyone! And that means another Primal Blueprint Real Life Story from a Mark's Daily Apple reader. If you have your own success story and would like to share it with me and the Mark's Da...

Where Are They Now? – Round 2

April 16 2010 - What is in a story about personal health and wellness? We all have them; every one of us. Yours might be about your relationship with food, or about your body image, or about weight loss, or about ove...

Welcome Back Grok: 30 Days of Self-Discovery

December 16 2011 - It’s Friday, everyone! And that means another Primal Blueprint Real Life Story from a Mark's Daily Apple reader. If you have your own success story and would like to share it with me and the Mark’...

What If I Don’t Want to Lose Weight?

October 26 2011 - I receive a lot of emails from folks worried about losing too much weight on the Primal Blueprint, underweight readers who need to gain weight, or the formerly overweight who have reached their target...

Did a Wrinkle in Human Evolution Predispose Us to Diabetes?

February 28 2011 - A new mice-with-an-engineered-human-genetic-deficiency study is out that promises to shed light on why humans are so darn diabetic and obese - and the cause is an evolutionary "mistake." A deficiency ...

Why Can Some People Eat Anything They Want and Never Gain a Pound?

January 12 2011 - The following are both actual and paraphrased versions of questions I regularly get from readers: If grains are so bad how can you explain the leanness and good health of Clarence Bass? How is i...

The Primal Blueprint 8 Key Concepts

September 12 2012 - With the Primal Blueprint 21-Day Challenge having just begun, it's the perfect time to go over the Primal Blueprint 8 Key Concepts. I believe that fully grokking these powerful ideas is crucial to suc...

Magnificent Muscle

February 16 2008 - A research study out this week indicates type II muscle mass associated with strength training not only helps reduce body fat but alters overall metabolism. Researchers from the Boston University Sch...

New Study: Exercise is Good and Lowers Obesity

September 11 2008 - In a new study out of the Archives of Internal Medicine investigators discovered that even people with extra copies of the “fat mass and obesity” genes called FTO did NOT get fatter if they were a...

Interview with Jimmy Moore of Livin’ La Vida Low-Carb

September 04 2008 - I'm sure many of you are familiar with Jimmy Moore. These days you can hardly say low-carb without thinking of him first. That's because he has a great low-carb success story and has created an amazin...

The Genetics of Obesity: Are You Destined to Be Fat?

August 30 2016 - The entire premise of the Primal Blueprint is enabling you to be the architect of your health and happiness. If we can identify the environmental triggers and selective pressures under which the human...

Why Fast? Part Three – Longevity

March 27 2012 - A time-honored and research-tested way to extend an animal's lifespan is to restrict its caloric intake. Studies repeatedly confirm that if, say, a lab mouse normally gets two full bowls of lab chow a...

Low Carb Diets Affect Short Term Memory

January 06 2009 - A soon-to-be published study in Appetite [2009 Feb;52(1):96-103] (but apparently already published online earlier this summer) done by a group at Tufts seems to have "proven" that when you remove carb...

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