Category: Longevity

Hunger and Satiety Hormones

Today we’re taking a peek under the hood and looking at some of the hormones involved in hunger and satiety, a.k.a. appetite hormones.

You might think of hunger as a gnawing feeling in your stomach and satiety as that feeling of fullness when you’ve eaten enough… or maybe too much. That’s how we experience the feelings we call hunger and satiety, true; but I’m talking today about the physiological drives to eat or stop eating that is driven by hormones.

Eating behavior is coordinated mostly in the brain by the hypothalamus, which acts as the control center for appetite. Hunger and satiety hormones deliver information from the body about how much energy you are taking in and whether you need more. The overarching goal here is energy homeostasis—balancing the energy coming in (via food) with the energy needed for the everyday functions of being alive.

When you have sufficient energy, your body is free to invest in growth, repair, and reproduction. Taking in more energy than you need can lead to excess fat storage and issues like hyperinsulinemia, insulin resistance, and metabolic syndrome. Energy deficits result in adaptations designed to conserve energy. In the long run, energy deficits might increase longevity, but they can also seriously undermine health and, for example, impair fertility.

Today I’m going to cover some of the key hormones that are involved in this delicate dance. This is by no means a complete list. Let me know in the comments if you have a burning desire to learn more about one of the hormones not covered here.

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Epigenetics, or What I Mean by “Reprogram Your Genes”

You can’t change your genes. But you can program them.

The modern world presents a number of problems for our genes. The world we’ve constructed over the last 50 years is not the environment in which our genetic code evolved. Our genes don’t “expect” historically low magnesium levels in soil, spending all day indoors and all night staring into bright blue lights, earning your keep by sitting on your ass, getting your food delivered to your door, communicating with people primarily through strange scratchings that travel through the air. So when these novel environmental stimuli interact with our genetic code, we get disease and dysfunction.

The genes look bad viewed through a modern prism. They get “associated” with certain devastating health conditions. But really, if you were to restore the dietary, behavioral, and ambient environments under which those genes evolved, those genes wouldn’t look so bad anymore. They might even look great.

This is epigenetics: altering the programming language of your genes without altering the genes themselves.

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How Fasting, Calorie Restriction, and a Fasting-Mimicking Diet Can Encourage Longevity

Hi folks, today’s post comes from my friend Max Lugavere, New York Times best-selling author of Genius Foods and The Genius Life, which will be available for purchase on March 17, 2020. Max is a young guy, but he’s accomplished a lot so far, including an impressive bit of research and writing about longevity and how to age optimally with grace. I know you’ll enjoy Max diving into the weeds a bit about the nutrient sensors, proteins, and catalysts that may help us live long, healthy, thriving lives. This post comes from an excerpt from Max’s newest book The Genius Life.

From now until March 11, 2020 at 11:59 p.m. PST, enter for your chance to win a FREE copy of The Genius Life as well as Primal Kitchen salad dressings and Primal Sun. All you have to do is head over to Instagram, follow @marksdailyapple and @maxlugavere, and tag some friends in the comments of the giveaway post. Three winners will be selected and notified via DM. Good luck, and enjoy the excerpt.

When it comes to slowing down the clock, life extension is indeed possible. The catch? There are two: it involves calorie restriction, and it has only been successfully demonstrated in lab animals. Studying longevity in humans is a bit more challenging. We don’t sleep in labs, we live a lot longer, and we like to eat. (Correction: we love to eat.) So while most of us would happily opt for a 40 percent increase on our life spans like food-deprived lab rats seem to achieve, we need a better route to get there.1

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4 Scenarios When Detailed Testing Makes Sense

We have unparalleled abilities to peer inside our bodies and take detailed snapshots of physiological processes and the state of our health. We can measure the hormones in our blood, the cholesterol in our veins, the nutrient deficiencies we may have. We can go deep. But it doesn’t always make sense to take that deeper, more detailed look at the numbers. It gets expensive, for one. It gets intrusive. Our doctors may be resistant. And it can provide a bit too much of a close look when a broader view might suffice.

When do more detailed tests make sense, though? What kind of scenarios call for a second, deeper look at our numbers?

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Dear Mark: How Often I Eat Organ Meat and Should You Take Metformin for Longevity?

For today’s edition of Dear Mark, I’m answering a couple questions taken from Instagram followers. Normally every Wednesday, I do a quick Q&A on Instagram. I wasn’t able to get to them last week so I’ll be answering some here on the blog. First, how often do I eat organ meat, and how do I like it? And finally, what’s the deal with using metformin for longevity?

Let’s go:

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The Definitive Guide to Blood Sugar

What’s sweet, red, sticky, and deadly?

Blood sugar. (I’m sure there are other things that qualify, but most of them contain sugar of some sort so I’m sticking with it.)

Too little of it, and you go into hypoglycemic shock. That can kill you if left untreated.

Too much of it, and you waste away slowly. Chronic overexposure to sugar will degenerate your tissues and organs.

Yes, getting blood sugar right is extremely important. Vital, even.

Today, I’m going to explain how and why we measure blood sugar, what the numbers mean, why we need to control it, and how to maintain that control.

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