For today’s edition of Dear Mark, I’m answering a couple questions taken from Instagram followers. Normally every Wednesday, I do a quick Q&A on Instagram . I wasn’t able to get to them last week so I’ll be answering some here on the blog. First, how often do I eat organ meat, and how do I like it? And finally, what’s the deal with using metformin for longevity?
How often do you eat organ meats?
Maybe twice a month. I should probably do it more.
It’s not that I dislike them. Every time I eat heart or liver, I enjoy it. It’s not something that comes intuitively to me. Because I wasn’t raised in a household where organs were a normal part of the daily diet, I have to remind myself to do it.
If you’re counting marrow, I eat that far more frequently. I order it every time I see it on a menu. I eat lamb chops frequently, which often come with little pockets of marrow.
And personally, I include eggs and shellfish as “organs.” Reason being, you’re eating the entire organism. The whole animal. Well, the egg isn’t an animal yet, but it contains everything one needs to construct an entire animal. These tend to be far more nutrient-dense than muscle meats.
If you’re looking to eat more organs, there are some great options.
You can go the product route. US Wellness carries fantastic organ sausages. Check out the braunschweiger  (60/40 blend of grass-fed beef and grass-fed beef liver) or the liverwurst  (GF beef, liver, kidney, heart). I’ve crumbled these up into ground beef and mixed into spaghetti sauce.
You can usually ask any butcher to make sausages or meat grinds with different muscle/organ ratios. You could do 70% beef chuck with 15% liver and 15% heart, or whatever ratio you prefer.
Ancestral Supplements does great organs in supplement form .
There are awesome recipes out there that “hide” the organs. I wrote an entire post  on slipping organs into normal meals that you don’t even notice.
Or you could just figure out a way to cook organs that you’ll consistently enjoy and consume. Here are some of my favorite ways:
- Ginger garlic chicken liver: Chop chicken liver into small pieces. In a pan, sauté ginger and garlic in butter or avocado oil. When it’s all softened, add a generous cup of gelatinous bone broth and reduce, reduce, reduce. When it’s getting syrupy, drop in the liver and stir over medium high heat for 2 minutes. The liver will cook quickly without overcooking.
- Beef liver sashimi: Get the best, freshest organic grass-fed beef liver you can find. Slice thin and marinate in fish sauce, sesame oil, and lemon juice for an hour. Eat raw, or briefly sear in a pan. If eating raw, might be advisable to freeze for two weeks first.
- Chicken heart skewers: Marinate chicken hearts in lemon juice, soy sauce, and a little bit of honey. Place on skewers and grill over coals or flame.
- Lamb/beef heart steaks: Slice a heart into steaks. Season with salt and pepper, and place on roasting rack in a 275°F oven for 15 minutes. Remove and sear briefly over high heat on both sides. Do not overcook. It will get tough and inedible.
What’s your take on supplementing Metformin for longevity?
There are certainly reasons to suspect it could help.
Metformin activates AMPK, the same autophagy pathway activated by exercise, fasting, polyphenol consumption, and reduced calorie intake.
Metformin also seems to protect against many of the conditions that kill people, like cancer. It lowers hyperinsulinemia and may protect  against insulin-related cancers (breast, colon, etc.). Early treatment during adolescence, for example, protects rats against later tumor growth .
Type 2 diabetics (a population with higher overall mortality) who take metformin live longer  than age-matched controls who don’t have diabetes. That’s huge. Type 2 diabetes isn’t enough to offset the longevity gains.
Metformin appears to work on lifespan via hormesis . Diabetics who need it just to keep their blood sugar in check are taking (and should take) it regularly, but if you’re just an experimenter interested in potential life extension, treating it like a hormetic input  like fasting or intense exercise is probably a better, safer approach. Instead of daily, maybe intermittently. Cycle it.
It appears  that metformin may also act via modulation of the gut bacteria (surprise, surprise). It increases mucus production in the gut, which the resident bacteria are able to feed upon and increase in strength and number. It’s been shown to boost Akkermensia count, the strain commonly linked to leanness and anti-diabetic effects. Some studies have even shown that Akkermensia can improve gut barrier  function in obese subjects, so metformin may be especially helpful for this population. Additional effects include reduced carb absorption by the host (that’s you), leaving more to be consumed by gut bacteria  (a la resistant starch ).
If you don’t want to (or can’t) find real metformin, berberine might be a “natural alternative” to metformin. Like metformin, berberine can activate AMPK , lower blood sugar and improve blood sugar control , and enhance short chain fatty acid production by gut bacteria . Being a whole plant extract, berberine isn’t identical to metformin, so I wouldn’t suggest diabetics switch without consulting their doctors, but it is a promising alternative that doesn’t require a prescription. It might be a viable alternative for someone looking to improve their longevity.
Overall, metformin looks promising. I’m not sure it’s an essential part of a longevity-promoting regimen if you’re already fasting , training , and eating colorful polyphenol-rich fruits, vegetables , spices , and dark chocolate . Many of the populations it seems to help in studies aren’t doing these things and metformin is likely acting as a “healthy living mimetic”—but I’m certainly open to the idea, and await further research.
That’s it for today, folks. Take care and keep the questions coming! If you have anything to add or ask, go for it down below.