Here at Mark’s Daily Apple, I avoid writing off anything without first investigating it. I keep one foot in the “alternative” health world and one in the “conventional” realm, making sure to maintain a skeptical—but openminded—stance on everything. There’s no other way to do it, if you’re honest. At least as far as I can tell.
No, not every alternative therapy works. A lot of it is pure hogwash. But whether we’re talking about off-label uses of conventional drugs and illegal drugs, natural pharmacological agents, or downright outlandish-sounding interventions, some therapies are worth considering. Not trying, necessarily. Considering.
Without further ado, let’s take a look at some of them:
Curcumin for Depression
The standard treatment for serious depression is the antidepressant. For years, researchers have been trotting out studies which pit curcumin—the primary phytonutrient in the spice turmeric —against conventional antidepressants or placebos.
- In 2014 , curcumin improved symptoms in patients with major depressive disorder, showing particular efficacy in people with atypical depression.
- In 2015 , researchers discovered that curcumin raised levels of certain biomarkers with proven antidepressant effects.
- Also in 2015 , researchers found that curcumin made antidepressants more effective.
- And this year , researchers again confirmed the benefits of curcumin in major depression.
Exercise for Depression
To their credit, doctors are quick to recommend exercise for the treatment of “physical” ailments like osteoporosis, obesity, diabetes, heart disease, arthritis, sarcopenia. It works, and it’s obvious and broadly accepted that it works. But evidence is emerging that exercise can also be an effective primary therapy for depression.
It’s especially good for people who don’t respond to SSRIs. In one study , 30% of folks whose depression did not respond to antidepressants experienced complete remission using exercise. In another , exercise improved self-rated sleep quality in depressed patients.
Psychedelics for Depression, Addiction, and Anxiety
Turn on, tune in, drop out… of your addiction, intractable depression, and crippling anxiety? Maybe.
In patients with terminal cancer, a single dose  of psilocbyin (compound in “magic mushrooms”) abolished depression and anxiety. That’s “end of life” anxiety and depression, by the way—the realest stuff around. Other studies have similar results .
Ketamine is a powerful sedative that in smaller doses produces psychedelic effects. More recently, it’s emerged as a rapid antidepressant, with single doses abolishing drug-resistant depression within 24 hours and lasting up to three weeks .
Ibogaine is an African psychedelic whose characteristics make it untenable for recreation but promising for addiction therapy. It’s been used to produce remission of severe opioid addiction . It’s effective against alcoholism  and nicotine addiction , and it shows promise against methamphetamine addiction .
It goes without saying that these are all powerful substances that also happen to be illegal in most places. Exercise caution. Several ibogaine clinics are doing good work in Mexico, so that’s an option.
Red Light for Joint Pain, Macular Degeneration, Thyroiditis, Cellulite, and Hair Loss
Shining infrared light on your bum knee and expecting anything to happen sounds ridiculous, right? Well…
- Patients with knee osteoarthritis used red light therapy to reduce pain scores and increase microcirculation in the knee . That could mean actual healing.
- Literature reviews have concluded that red light therapy does reduce joint pain . even in chronic joint disorders .
- Red light exposure increases blood flow to the skin  and improves fracture healing .
- It’s even been shown to improve neuropathic pain . No “physical” damage necessary.
There are other effects, too.
- Applying red light to the eyes of seniors with macular degeneration significantly improved  visual acuity after just two weeks. The benefits lasted for at least three years. Yes, years.
- Applying red light to the skin covering the thyroid gland in patients with autoimmune thyroiditis for ten sessions improved thyroid function . Placebo did not.
- A red light-enhanced comb appears to stimulate hair growth  in both men and women with hair loss.
- Red light may even help smooth out cellulite , though the jury is still out.
Fecal Transplants for Antibiotic-Resistant C. diff Infections
A friend of mine’s father passed from cancer a decade back. While the cancer ultimately did him in, one of the severest blows occurred when he picked up a nasty case of antibiotic-resistant C. diff in the hospital on a routine check with the oncologist. He was stuck there for weeks. Nothing worked. There’s no question he lost several months or years from dealing with the ramifications of constant watery diarrhea and poor sleep (from being woken up by his rumbling stomach).
I wish I knew about fecal transplants back then, because they are the single most effective (and in many cases, only) way to treat drug-resistant C. diff infections .
Modern sterility, medicine, and hygiene have eliminated helminths, yet our immune systems, which evolved in the presence of these parasites, expect them. There’s good evidence that our immune systems are “overactive” without a parasite load to attack, and this has given rise to the increase in asthma, allergies, intestinal diseases, celiac, and even multiple sclerosis.
Helminthic therapy—literally giving yourself worms—sounds gross, but it really does seem to help people deal with some of these conditions .
Forest Bathing for Stress, Diabetes, Hypertension, and Immune Health
Strolling along a wooded path sure is pleasant, but evidence out of Japan—where forest walks known as “forest bathing ” are a cornerstone of modern medicine—shows that it can treat disease and ill health. It lowers stress and reduces cortisol, improves blood glucose control (compared to the same amount of walking in a city setting), reduces blood pressure, and increases the activity of cancer-fighting natural killer cells . What’s best of all? Many of these effects last for weeks  after a single visit.
But don’t just go once a month. Go as often as possible. Get your green space  (even if you’re not sick).
Low-Dose Naltrexone for Seemingly Everything
At normal doses, naltrexone blocks opioid receptors, inhibits GABA activity, and prevents dopamine release, making it great for alcohol or opioid addiction. At low doses, naltrexone blocks opioid receptors just enough to provoke the release of our natural opioids, the endorphins, which helps balance out the immune response and reduce inflammation. A growing number of clinicians are now using low-dose naltrexone as an off-label drug to treat conditions like multiple sclerosis , fibromyalgia , Crohn’s disease , autism , chronic pain , and cancer .
As the immune system and inflammation both play major roles in seemingly every health condition, low-dose naltrexone is also being explored by clinicians in many other fields , including fertility and autoimmune diseases.
That’s it for today, folks. I’d love to hear from you.
What alternative therapies are you curious about? Which ones have you used? Are there any you’d like me to explore further?
Thanks for reading!