Marks Daily Apple
Serving up health and fitness insights (daily, of course) with a side of irreverence.
10 Feb

What’s Messing with Your Appetite? Three Possibilities.

HungryAlthough a few weeks ago I explained how “stop eating so much” is bad weight loss advice and how “calories in, calories out” tells us very little about the cause of obesity, the fact remains: for whatever reason (and there are many), people who gain weight have eaten more energy than they’ve expended. Something is causing them to eat more food than they need. Something is making the hungrier than they need to be, desirous of more food than they require for sustenance and weight maintenance. What could it be? There are the basic remedies. Eat more protein to promote satiety. Reduce carbs, increase fat. Get enough sleep and limit stress as best you can. These are proven ways to normalize your appetite, but you already know about them. I also have a few speculatory ideas that you may not have considered, and today I’m going to discuss them.

Before donning your skeptic hats and demanding randomized controlled trials, remember that these are theoretical appetite perturbers. Most of the ideas I propose draw on in vitro studies examining potential mechanisms, observational studies looking for hypotheses, circumstantial evidence, and the occasional controlled trial. These are not intended to be absolute statements of truth. These are conversation starters that get you thinking and experimenting. They may work. They may not work. They are, however, safe to explore on your own.

Grain protein fragments causing leptin resistance.

Leptin fills a great many roles in the body, but it’s probably most well-known for its inhibitory effect on appetite. Using the amount of body fat you’re carrying as a barometer, leptin determines how well-fed you are and adjusts appetite accordingly. In a perfect world, body fat secretes leptin and leptin receptors in the brain receive it. Appetite is regulated, weight is maintained. But what if something blocked that connection between leptin and its receptors? You could have sufficient circulating leptin but without the brain’s ability to perceive it, the appetite suppression would never occur.

The idea that grain proteins might bind to the leptin receptor and induce leptin resistance was first proposed by Staffan Lindeberg in his 2005 paper. In a recent paper, researchers put gluten through in vitro digestion (where they simulate human digestion using pepsin and trypsin), filtered it off using either a spin-filter (no heat) or 100°C (heat), placed the two different gluten digests (great magazine name right there) with leptin and leptin receptors in an environment simulating human serum, and observed the reactions. At a simulated serum level of 10 ng/mL, gluten that had undergone spin-filtration inhibited leptin binding to leptin receptors by 50%. Since breastfeeding mothers on unrestricted diets have shown mean serum gluten levels of 41 ng/mL in the past, this in vitro finding could have ramifications beyond the test tube.

Too many aceullular carbs.

A “cellular carb” is glucose that’s stored inside a fiber-bound organelle. Think tubers, roots, fruits, leaves, and any whole food source of carbohydrate. Even a whole wheat berry, for example, is an example of a cellular carb until you turn it into flour.

An “acellular carb” is dietary glucose that’s been liberated from its cellular cage. Think flours, especially cereal grain flours, and all the foods made using flour, like cookies, cakes, bread, pretzels. Think fruit juice. Think pulverized dried fruit bars and energy bars.

In his 2012 paper, Ian Spreadbury proposes that excessive intakes of these acellular carbohydrates are responsible for our dysregulated appetites and the modern obesity epidemic. When we eat cellular carbs, they remain intact and inaccessible until breached by digestive processes, reducing the concentration of carbohydrate available to the gut bacteria. When we eat acellular carbs, the glucose is immediately released into the digestive chyme, increasing the concentration of carbohydrate available to the gut bacteria far beyond evolutionary precedent. Spreadbury shows how this might perturb appetite:

  1. This concentrated influx of dense carbohydrate into the gut produces an inflammatory microbial population that increases production of bacterial endotoxin and increases intestinal permeability.
  2. Increased intestinal permeability allows bacterial endotoxin into the body.
  3. Once in circulation, bacterial endotoxin induces leptin resistance and (in rats) increases food intake.

We are not rats, nor have controlled human trials been done looking at the effect of chronic acellular carbohydrate intake on leptin resistance, appetite, and bodyweight. But we obtain the vast majority of our carbohydrates from acellular sources, and we’re the fattest we’ve ever been in human history. Meanwhile, for the vast majority of human history we obtained the vast majority of our carbohydrates from cellular sources and remained lean and fit. And studies of modern pre-industrial cultures like the Kitava who consume ample carbohydrates in the cellular form of tubers and fruit show little evidence of obesity, leptin resistance, or dysregulated appetite.

As a little thought experiment, ask yourself two questions. Which carbohydrate foods do the healthy, lean people you know prefer? Which carbohydrate foods do the overweight, unhealthy people you know prefer? Then, take a look at this chart showing the carbohydrate density of modern and ancestral carbohydrate sources. Notice anything?

It’s a plausible hypothesis — don’t you think?

PUFA-induced munchies.

Induction of the munchies can be a pleasant way to increase one’s enjoyability of food, but it’s a double-edged sword: the worst kind of food looks especially delicious when the right cannabinoid receptors are triggered. And due to the presence of endogenous cannabinoids, or endocannabinoids, we can get the munchies without even trying.

In animals (including humans), the endocannabinoid anandamide is an important hunger signal, increases appetite, and intensifies the reward we get from junk food. There’s extensive animal research showing that dietary linoleic acid, the PUFA found abundantly in the seed oils used in everything these days, contributes to a rise in anandamide. For instance, a 2012 paper showed that increasing the linoleic acid content of a mouse’s diet from 1% to 8% of energy (paralleling the rise of linoleic acid in the human diet over the past century) tripled anandamide levels and increased food intake, body weight, and body fat. Dropping the linoleic acid back down to 1% of energy resolved the issue; so did adding fish oil at 1% of energy.

These were mice, yes. Anandamide is active in humans, though, increasing appetite and the reward we get from food. And there’s some evidence that the same treatment in the linoleic acid-fed mice that normalized their anadamide and appetite levels — omega-3 supplementation — works in humans. A group of mildly obese German men were split into two groups. One group got 4 grams of powdered krill every day and the control group received nothing. The krill powder group reduced their serum anandamide levels by 84% after 24 weeks; this improvement was mediated by an improvement in EPA and DHA status. There’s no indication of the baseline diet, but since this indicates that German adults get about 6.5% of energy from PUFAs, it probably contained significant amounts of linoleic acid.

Although I find the evidence for excessive linoleic acid’s stimulatory effect on appetite to be compelling and worth a closer look, it remains to be seen if soybean oil can make you wonder what if, like, the universe is all just a simulation, dude? These ideas are easy enough to explore on your own.

  • Stop eating cereal grains, especially gluten-containing grains. Be strict for a month. How’s your hunger?
  • Stop eating processed food, flour-based food (even coconut or almond flour paleo baked goods), and other acellular carbohydrates. Be strict for a month. How’s your hunger?
  • Reduce linoleic acid intake to 1% of total energy. Be strict for a month. How’s your hunger? (Additional trial: increase long chain omega-3s from marine sources to 1% of energy.)

Not too complicated, completely safe (no doctor required), and likely to have an effect. Why not give it a shot?

Let me know how it goes for you. Thanks for reading, everyone.

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You want comments? We got comments:

Imagine you’re George Clooney. Take a moment to admire your grooming and wit. Okay, now imagine someone walks up to you and asks, “What’s your name?” You say, “I’m George Clooney.” Or maybe you say, “I’m the Clooninator!” You don’t say “I’m George of George Clooney Sells Movies Blog” and you certainly don’t say, “I’m Clooney Weight Loss Plan”. So while spam is technically meat, it ain’t anywhere near Primal. Please nickname yourself something your friends would call you.

  1. I read this as I ate a bowl of cereal … and I know every time I start my day with cereal versus protein I don’t have as much energy for the day!

    Erica wrote on February 10th, 2015
    • Lol then why do you do it?

      Zach wrote on February 10th, 2015
    • The last bowl of cereal I ever had was 3 years ago, and haven’t looked back. If I feel like carbs, rice, meat and Veggies works well.

      Storm wrote on February 10th, 2015
    • I think you need to hear this. A bowl of cereals it the worst way to start your day. You get homogenized milk (denatured proteins and fats), sugar and grains, possibly gluten grains. Good news is it will only get better. If you aren’t ready to switch to pastured eggs, a small step up would be rolled oats in raw milk and just a bit of honey. Baby steps.

      Nitin wrote on February 11th, 2015
  2. This is the high quality MDA style post I know and love!

    Groktimus Primal wrote on February 10th, 2015
  3. Love the insights.

    Having lived through constant hunger to never hungry I was thinking about this a lot. I have related ideas. Toxics in non-organic fruit and veggies, processed foods leads the body to intentionally store a lot of it as fat even beyond the normal fat storage of a high carb meal.

    What if the body is incredibly smart and ‘knows’ there are toxins in processed food, so routes as much as possible the food into fat storage. Even more than it would otherwise? So an organic potato without round up on it would lead to slightly less food going into fat than the same non-organic more toxic potato. But overtime that would add up.

    Also with IBS you are not absorbing a lot of nutrients so your body needs more so keeps you hungry.

    Then the blood sugar crash, constant need for carbs as a carb burner.

    Basically the SAD diet keeps a lot of folk constantly hungry. I understood this and it led me to discover Mark, Taubes, Paleo, Primal. Before I even read Taubes I knew not all calories were equal..at all, from my lived experience.

    But in any case Primal and as high quality as you can go, real food is a wonderful hunger cure. Spectacular actually.

    Freedom at last.

    Larry wrote on February 10th, 2015
  4. Are green shakes still considered cellular? Those which have simply been blended (rather than “juiced”), of course.

    Jason wrote on February 10th, 2015
    • That’s a good question and I’d like to know too. :) I think they are, but I’m not sure.

      Wildrose wrote on February 10th, 2015
    • Essentially, anything ground is Acellular, hence the recommendation to exclude coconut an almond flour. Your blender broke down te cell aleady so your body skips that energy intensive step.

      Zach wrote on February 10th, 2015
    • Difference being that greens still don’t have a lot of carbs in them.

      Sofie wrote on February 11th, 2015
    • I, too, am very interested in this question. I have a Nutribullet where the claim is extraction versus blending… I like to have a few a week as it’s an easy way to get servings of kale, parsley, spinach, tomatoes, endive, watercress, chard, chia seed, maca powder, flax seed, spirulina, or whatever I have in my diet…

      Anyone have further thoughts along the acellular fronts?

      Jason wrote on February 11th, 2015
      • It’s just a blender that only has a puree speed. If you’re sticking to mostly low carb items, like non-starchy vegetables, then it probably makes little difference.

        Erik wrote on February 23rd, 2015
  5. I stopped eating cereal grains and feel much much healthier. I think there are a lot of sugars in the grains that aren’t healthy for you as well. Thanks for the healthy start to my day tip!

    John Mondin wrote on February 10th, 2015
    • Couldn’t agree more. Only proteins and fats in the morning is the way to go for me and sometimes only fat breakfast works great too (bulletproof or any other fatty coffee).

      Nitin wrote on February 11th, 2015
  6. Love the idea about stopping the nut flours for awhile (paleo banana bread anyone). I occasionally partake of those, but have always felt it was kinda like a cheat day.

    Nocona wrote on February 10th, 2015
  7. I have been feeling INSATIABLE hunger the last few weeks. I have only been obtaining about a 70/30 due to corn tortilla and tortilla chips + a hamburger and a pizza night all in the same week (I normally have a hamburger once every 3 months and pizza even less! But I was CRAVING IT) :( But I am still getting a ton of meat, veggies, and lots of good fats. My husband says he thinks I am pregos… but have never been, so I don’t know if that is something that would show through hunger so early on. I am go to try to tighten up the percentages and see if the hunger chills out. I haven’t had any weight gain though, and my body is normally VERY reactive to food choices.

    Margarey wrote on February 10th, 2015
    • Time for a pregnancy test.

      Josh Klemme wrote on February 10th, 2015
      • ^^ Lol. But yes, I would agree :)

        Becca wrote on February 10th, 2015
    • There are no hard and fast rules about pregnancy symptoms, but yes, hunger can increase very early on, and carb cravings are fairly normal. With my oldest, my initial symptoms were mild and PMS-like, without the irritability. I had a slightly increased appetite (this varies greatly among women) and breast tenderness, even before my period was due. (It should be noted that some women never miss a period while pregnant, though it is generally lighter.)

      The fact that you haven’t gained weight under a situation where you normally would, indicates that something has changed. However, it could be that your body has adapted to primal eating well enough that your slight bump in carbs, even processed ones, may not be enough to make you gain weight, or that you are being more active, thus need the extra carbs. You could be consuming less carbs elsewhere in your diet. There are other possibilities as well, ones that just have not occurred to me yet.

      I’m going to agree with Josh and Becca – time for a pregnancy test. If you’re been experiencing an increased appetite “for the last few weeks,” you’d be far enough along for a pregnancy test to be very reliable.

      b2curious wrote on February 11th, 2015
  8. Anecdotally, I consider the idea about acellular carbs absolutely true. Both my wife and I have gone months where the only carbs we eat are fruits, veggies, and safe starches (white rice mostly). We lose weight easily, and have no cravings between meals. If anything, I have trouble keeping weight on during these times (I’m a fit and active ectomorph).

    When we add any sort of processed carbs or sugars, even though they are all made of gluten-free and “paleo” ingredients, we both notice an immediate increase in that “rumbly tummy” type of hunger. The more we feed this “carb and sugar” monster, the more he returns the next day, with a bigger appetite. It usually takes at least two or three days of low carb eating, and avoidance of acellular foods, to get back on track with the general sense of satiety we experience when eating only whole food carb sources.

    George wrote on February 10th, 2015
  9. Very cool article! I’ve noticed that my appetite is WAY more under control when I eat a protein and fat heavy whole foods diet (versus around the holidays when I indulge in more treats and my appetite goes out of whack!). But I never knew about the cellular / acellular carbs part. It makes a lot of sense to me and is definitely something I will keep in mind when choosing carbs in the future (even “paleo” friendly flours like almond & coconut). Thanks!

    Christine wrote on February 10th, 2015
  10. Makes sense… I can go to a place that serves bread and eat WAY more than I normally would **cough cough** Red Lobster **cough**

    Jacob wrote on February 10th, 2015
    • Those cheddar biscuits are like crack.

      Curtis wrote on February 10th, 2015
      • Haha I’m utterly convinced they do have some nefarious drug in their biscuits because it’s nearly impossible to stop after you’ve eaten one.

        Jacob wrote on February 10th, 2015
      • I find that if I pulverize them and inject them directly into my blood stream I can get by with only having one. Otherwise, all bets are off.

        Marti wrote on February 11th, 2015
  11. I’ve been reading your site for years, and one of the things I wish you would address are the roles of infection, micronutrient deficiencies, and finally lack of calories PERIOD in appetite dysregulation. Sometimes the answer isn’t less carbs, more protein, more fat, but a real true issue like a parasite, hypothyroidism (from either a nutrient deficiency or infection), or the person has an eating disorder and 1200-1500 calories a day isn’t really the appropriate amount of food for them to be eating for weight loss.

    JM wrote on February 10th, 2015
    • I don’t think Mark has ever said not to count calories to maintain a healthy weight. He HAS said calories aren’t the end-all-be-all for weight loss. What you eat is as important as how much you eat.

      Jacob wrote on February 10th, 2015
      • not that any one will care at this point on this comment, but here goes:

        In this post where someone worries about not having appetite/getting in too few calories on Primal, MSisson says, “Hey, maybe that’s a good thing…listen to your body”

        http://www.marksdailyapple.com/eating-too-little-food-paleo-primal/#axzz3W4XKm3bG

        Then, in the same post, he says – BUT – watch out for these signs that also could be from your body that you’re not eating enough – feeling a little more cold, feeling a little more tired or apathetic, having a little bit more belly fat. To which my response is, thanks for these awesome markers that are SO specific and will instantly let me know that something is wrong (can you sense my sarcasm?).

        So basically, Msisson’s advice is listen to your body until you shouldn’t listen to your body anymore. is the body rational or not? why should I trust some signals (less hunger) but not others (feeling a little more cold and having a teensy bit more body fat?)

        If I am a regular Joe person on primal who starts to see a little more belly fat, I don’t think the response of most people would be to increase calories, do you?

        I think any sane person could just as easily say, “But geeze, isn’t it nice to eat less because this has worked so well before with weight loss/body recomposition? Maybe I need to go from 1800 calories down to 1600 calories, and it’s easy enough because with primal food I never feel hungry!!”

        Sure, food quality matters….I will give that to you. But even someone very sympathetic to primal/paleo ways of eating, Peter Attia, an MD, of Nutrition Science Academy, finds that he averages around 3300-36000 calories a day, which is what a normal healthy, 25+ YO male who eats any diet needs to maintain his weight and perform normal metabolic functions.

        I God-darn guarantee you if you emailed the guy and he was your personal doctor and you said, “Hey doc, I find I can’t stomach more than 1000 (or 1500 calories or 1800 calories) calories on this new diet, do you see that as a problem?” he would say, “YEAH that is a problem!!!” And you’d reply, “But even if I’m eating completely nutritionally filling calories – egg yolks, seafood, potatoes, green veggies – nothing empty, not like a shakeology diet or something stupid like that?”

        Maybe I give Attia more credit than he deserves.

        Likewise normal caloric intake for women in the 25+ range is 2500 calories per day, and I think it’s irresponsible for MSisson not to acknowledge that.

        When you start to mess with your appetite, whether by unhealthy dieting – diet coke plus lettuce plus apples plus candy, or healthy dieting – your grass fed beef, egg yolks, big ass salad, and wild caught salmon – your body is still in need of calories. You can have 800 calories of unhealthy shit or 800 calories of nutritionally dense food, and your body is going to need more food. So maybe with eating purely Primal, you can put off anemia a little longer, but your body still doesn’t have enough to do longer term functions like build and repair bone. Depriving yourself of calories, no matter how nutritionally sound your diet is, will mean your body has less foundational matter with which to repair itself.

        I saw the stupidest thing on a blog the other day – there is no such thing as a calorie receptor on a cell. No, but there are cholesterol and glycoprotein receptors, and channels for various nutrients. Calories from your food – whether a Coke or an omelet – are broken into their component parts for use by RNA and cells. To say otherwise is stupid.

        Back to Peter attia – The Primal/keto type diet is so satiating, I’m sure that Peter Attia could feel just as satiated on less food, so why are his calories so high? Why does he make himself basically chuck down an entire carton of heavy cream if calories don’t matter? Don’t you think he would be concerned if his daily caloric intake averaged to 2,500 calories a day instead of 3,500 calories a day? I’m sure he would be… because calories matter. I never said quality didn’t matter, but in times of infection (which we all have in some way or another), calories needs are increased, and in general, the 2000 calorie recommendation per day for most anyone is too low…but it’s fine, because weight is perfectly correlated with health anyway (again, sarcasm).

        http://www.theatlantic.com/health/archive/2011/08/why-does-the-fda-recommend-2-000-calories-per-day/243092/

        http://www.youreatopia.com/blog/2011/9/14/do-i-need-2500-calories.html

        JM wrote on April 1st, 2015
  12. Could the acellular carb thing be one of the reasons why rice-eating populations have been seen as healthier than grain-eating?

    Pete wrote on February 10th, 2015
  13. Those darn endocannabinoids!!! I have NO trouble avoiding acellular carbs–but if I delve into them on a cheat day I end up a glutton! And that’s more than weight gain–for me it’s a sin!

    During the week my wife and I are opposite eaters– she can eat grains and stuff all day–not me.

    If i could stay at church all day Sunday and avoid the home pantry and the kids coming over and munching for hours– I’d be at my ideal weight already!

    Pastor Dave wrote on February 10th, 2015
    • ..sounds like you need to give that home pantry a clean out. I find if its not in the house, then the cravings will pass by the time I decide I want to go to shop. Like shonky salespeople “Don’t let them in the front door to begin with” – lol

      Storm wrote on February 10th, 2015
      • You’re correct–but I’d have to “clean out” my carb loving wife too!

        Pastor Dave wrote on February 11th, 2015
        • +1

          Jack Lea Mason wrote on February 11th, 2015
  14. I am halfway through the whole30 and have not had gluten, coconut or almond flour or any grains for about two weeks now. My appetite has diminished so much that I was actually thinking this morning that now I could do one of those 24-hours fasts that you talk about on this site. Prior to this experience, I would have been too hungry to even attempt it!

    Julie wrote on February 10th, 2015
  15. Ok this article is great and would explain my weight staying where it is.. I’ve been strict paleo/primal for about 9months but do have baked paleo goods each week that I bake myself but always thought it would just count as my nut and banana intake for the day. But it makes them acellular carbs using almond and macadamia meal, bananas, berries and eggs..

    Thanks, going to give 30days of no acellular carbs a go and see how it works out :-)
    Ps I love this site :-)

    Carly wrote on February 10th, 2015
    • Hey Carly– I had the same problem but recently went back to IF and cut out any acellular carbs–its starting to work–not fast but it’s working

      Pastor Dave wrote on February 11th, 2015
      • Hi! Seems silly but do you mean intermittent fasting when you say IF?

        I have officially cut out my acellular carbs and reduced my carb intake fullstop for a little while to go into a ketogenic state for a couple of weeks.. see how I go 😊
        Cheers

        Carly wrote on February 11th, 2015
    • Yeah, it could explain things for me too. I’d always blamed the fact that I don’t get enough sleep during the week, which is definitely a factor. However, during the week, my breakfast is a smoothie made with coconut milk, half-thawed fruit and berries, vanilla, and honey. On weekends it’s bacon and scrambled omlets. (What most people would turn into an omlet, i just scramble with my eggs.) I do eat less on weekends, but is it because I’ve gotten more sleep, am eating protien first thing in the morning, the lack of acellular carbs, or some combination of the three? I’m going to have to try not blending my smoothie and just eating the ingredients.

      b2curious wrote on February 11th, 2015
  16. I believe that the most important influence on hunger, cravings and insulin resistance/metabolic disorder is added/free fructose. There are multiple recent studies showing that fructose which is not part of whole food overwhelms the liver, leading to insulin and leptin resistance.

    See nofructose.com and davidgillespie.org/12-ways-fructose-destroys-your-body/

    Fructose is found in all sugar including honey, maple syrup, agave syrup, HFCS, coconut sugar, white and brown sugar, balsamic vinegar, dried fruit, fruit juice. Our liver can not cope with the influx, even if it is a natural source. Whole food has fibre and water which slow the influx of all nutrients.

    Sugar in all forms is addictive.

    Debbie wrote on February 10th, 2015
  17. I’d like to add another possible culprit- major disruption of gut bacteria. After a year of happily eating VLC I had to do a three week course of oral chemotherapy. There were not tons of side effects, except that all protein seemed disgusting almost immediately, and I started to crave carbs and sugar like crazy. I don’t know when or how I’ll get my gut and eating back to normal. Of course, most people don’t have to take toxic drugs, but what about a bout of stomach flu, or a course of antibiotics? I bet these could affect hunger via microbial disruption.

    Allison wrote on February 10th, 2015
    • This is a really excellent question. So much interesting info about how our body’s flora influence us, in some cases quite profoundly. More importantly, I hope the chemo worked and you can address your gut health v. cancer. I’m sure you know there are tons of resources inc on MDA about rebuilding a healthy GI system. Best wishes for healing!

      Juli wrote on February 12th, 2015
    • I recently had a medical issue where I was prescribed narcotic painkillers, which I feel totally wiped out my gut flora. I had the crazy carb and sugar cravings ALL THE TIME!! Prior to that time I did not have cravings. It took a couple of weeks after weaning myself off the narcotics that I was able to function normally again, i.e., not thinking about eating junk all the time. I also started to eat sauerkraut and take a strong probiotic/prebiotic. I feel much better, but I know I have a ways to go. Good luck on your journey to better health.

      Kim wrote on February 12th, 2015
    • I’m curious for what condition you were prescribed oral chemo? I realize it is absolutely none of my business, but if you are willing to share, I’d be interested to know. I know methotrexate is sometimes prescribed for autoimmune disorders, which is scary!

      Erin wrote on February 12th, 2015
      • Metastatic melanoma. The oral chemo is being treated as a stopgap – I’ve already gotten several of the brand new drugs that are truly miraculous. There are three new drugs on the market now that have good chances of causing full remission in people with melanoma, with almost no side effects to boot. Unfortunately, they don’t seem to have worked for me. Jumping to the next lily pad.

        Allison wrote on February 15th, 2015
  18. I’m still not clear on the difference between, for example, the juice of an orange vs. a pulverized orange (think Vitamix smoothies), vs. a whole orange, peeled and eaten as is. I always thought I was doing ok as long as I ate whole foods – I love a parsnip and cauliflower mash…

    Kimberly wrote on February 10th, 2015
  19. Where would mashed sweet potato and pumpkin fall? Are they as-cellular food?
    I feel that whenever I eat either, my hunger increases. Is it better to bake whole, slice and chew?

    Lena wrote on February 11th, 2015
    • I notice a difference when I eat mashed cauliflower v. roasted or raw. Maybe it’s a texture thing but I feel less full and notice that I’m less sated. Even with the added butter. I wonder if this is why. Since I rarely eat anything that isn’t a whole food (and I’m rarely hungry), this makes sense to me. Interesting.

      Juli wrote on February 12th, 2015
  20. We are not rats,
    We are not rats,
    We are not rats,
    ok = got it….

    healthywings wrote on February 11th, 2015
    • But– if you are what you eat and you eat RATS….!

      Pastor Dave wrote on February 11th, 2015
      • okay – I get your point (and ha!) but we are only what we absorb from what what we eat… 😉 (wink)

        healthywings wrote on February 11th, 2015
  21. I’ve been on a 2 month trial of 5 cups of carrot juice a day (since cut short). It’s a cancer cure. I want to write about it so wanted to give it a go. My lbs rumblings went crazy, of course. I knew it was the carrots but didn’t know about the acellular thing… kind of a double whammy: all that unchained fructose :)

    When I first started this, I ended up drinking most of my juice at night because it was hard to remember during the day. I woke up a couple of mornings with a full-blown hangover headache — this happens when I eat too much white rice or white potatoes at night without a balance of fat and protein. Hideous, I’m in bed all morning and requires 4 aspirin.

    I’m still drinking a little carrot juice but balancing that with much more fat. Back to feeling good!

    Sally Oh wrote on February 11th, 2015
    • Gosh it’s well known that cancer simply loves sugar, especially fructose so I’m wondering how that can be a cancer cure.

      Carly wrote on February 11th, 2015
      • Read Curing Cancer with Carrots. Excellent book, very detailed, quick read. She addresses the sugar issue, it’s not as simple as “cancer loves sugar.” Carrot juice alone has worked for many people, as has the Gerson Therapy. There are so many cures for cancer available to us.

        Sally Oh wrote on February 11th, 2015
    • Have you ever tested your fasting blood sugar the next day? I have and found that morning headaches were high-blood-sugar related, caused by too many simple carbs before bedtime.

      LeslieB wrote on February 12th, 2015
      • Yes, I agree. My ‘lbs’ abbreviation in my original post is low blood sugar.

        Sally Oh wrote on February 12th, 2015
  22. I have the opposite problem. My appetite is low (I eat low carb) and I struggle to eat enough to have energy for working out etc.

    Hemming wrote on February 11th, 2015
    • I am kind of the same boat and I am trying to put on lean mass. You may find eating a bit of carbs in the night helpful – like sweet potato or rice. To make them lower GI, boil and cool them and eat them the next day. I like to use carbs as a smart fuel.
      It’s all proteins and fats till evening, then may be a piece of fruit and some whole food starches in the dinner with heaps of protein and fats and veggies.

      Nitin wrote on February 11th, 2015
  23. The radio rage player post is definately the best i have read today.

    Harper Henderson wrote on February 12th, 2015
  24. Good thing acellular protein isn’t an issue or you’d be whey out of business in no time. 😉

    Peter wrote on February 13th, 2015
    • Mark does like a joke after all.

      Kit wrote on February 14th, 2015
  25. hi !!!
    i am 29 years old woman from india . my weight is 83 and my height is 5ft 1 inch ….. so much fat i have :( .. i want to reduce weight but i feel tis like impossoble to me in this life ….. i was 68 kgs in 2011 before my child birth . after his i continoulsy gain weight due to my overeating and non exercise routinr … now i want second baby in coming years and i know its really risky to get pregnant with this huge weight ..it will create so much disease to me n my second baby ..so i want to reduce weight seriously now … but my peoblem is henever i thimk about weight loose …. i eat more ..i eat so many sweeets or even bread with more butter or anything … pastries ..now a days i am so carving about sweet things ..i cant resist me to eat sweets or samosa or any fried food …
    please help me out .. i want to reduce weight but i have zero willpower to sustain in my goal ….
    thanks in advance

    prachi wrote on February 20th, 2015
  26. I have been looking into this for a while, and I definitely believe there is something to the acellular vs cellular gut microbe train of thinking. What I’m a tad confused about is why cellular grains like whole oats, corn, and I believe even brown rice would still be recommended against? And white rice, which would be acellular is still okay? Also, where do beans and legumes fall into this. From thier structure I believe they are also cellular carbohydrates, and would be considered healthy? i certainly home it’s not still the Phytate and lechtin argument, since that seems a bit irrelevant when the food is cooked.

    James IV wrote on January 19th, 2016

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