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My Top 6 Anti-Inflammatory Foods
Posted By Mark Sisson On January 25, 2012 @ 8:00 am In Diet,Nutrition | 202 Comments
Before I begin, let me preface this post with the identification of a simple confounder for everyone to consider as they read: context. Any discussion of a concept as nebulous, multifaceted, and confusing as inflammation must integrate the question of context. Inflammation itself is highly contextual – as I’ve discussed in previous installments , there are times when inflammation is a good thing and times when inflammation is a negative thing. There are also times when anti-inflammatory actions, drugs, or foods are negatives, even though “anti-inflammatory” has a positive connotation. If you blunt the post-exercise inflammatory  response with an anti-inflammatory drug, for example, you also run the risk of blunting the positive effects of that workout .
We must also pay attention to acute and systemic inflammation when discussing the desirability of an “anti-inflammatory” food. Eating a big meal tends to raise inflammatory markers  in the short term. If you’re overeating every single meal, this is problematic; the acute will become the norm – the chronic. If you’re eating big after a massive workout session, or because you’re celebrating at an amazing restaurant with your dearest friends, or because you’re coming off a twenty-four hour IF , it’s fine. Context.
Eating high glycemic foods, namely refined carbohydrates that digest quickly and represent a big, instantly-available caloric load, tends to raise inflammatory markers in the short term. Again, if you’re pounding bags of chips or white bread while sitting on the couch and the only walking you’ve done all day is to the pantry, those high glycemic foods will be inflammatory (to say nothing of the antinutrients in the bread  or the rancid vegetable oil in the chips). And if you do the same thing on a regular basis, they will induce systemic inflammation – or at least continuous acute spikes that mimic systemic inflammation. If you’re eating a fast-digesting, high-glycemic white potato  after your glycogen-depleting sprint  workout, you will refill your insulin-sensitive muscles and the subsequent inflammatory spike will be either nonexistent or nothing to worry about. Competitive athletes probably thrive on high glycemic foods, couch potatoes develop metabolic syndrome eating the same things. Context.
Many people find dairy  to be inflammatory. I’m (sort of) one of them. I’ll readily eat butter , put cream in coffee , slice quality cheeses , and have a cup of Greek yogurt , but a tall glass of store-bought milk doesn’t sit well with me. I don’t have to run to the toilet or anything; I just don’t feel as good as I did before the glass of milk. Is milk, then, “inflammatory”? It could be, for me (though perhaps a glass of raw A2 cow, goat or sheep milk would have a different effect). It may not be for you. Dairy certainly wasn’t inflammatory for this group of adult men with metabolic syndrome , nor for this group of pregnant women . For both groups, the inclusion of dairy had an anti-inflammatory effect. That doesn’t mean dairy is inherently anti-inflammatory; it might just mean that dairy  was better than whatever it replaced. Context.
So when I begin to rattle off my list of anti-inflammatory foods, keep these confounders in mind. Realize that what’s good for the chronically-inflamed, vegetable oil-guzzling goose may not be as crucial for the sprightly, sardine-slurping gander. If you’ve got a casein allergy, even the Maasai-iest dairy  will be inflammatory. But what follows is a list (plus scientific references where applicable) of foods I’ve personally found to be anti-inflammatory. Since I don’t carry around a CRP-ometer, I’ve tried to include references if available.
Whether you get it through molecularly-distilled oil, deep-red wild sockeye, raw oysters , or by exclusively eating pastured animal products, omega-3s  are required for a healthy inflammatory response. I feel off when I haven’t eaten any fish for a week or so, but eating salmon  more than three days in a row doesn’t really work, either, because too much omega-3 is similarly problematic (shoot for between a 3:1 and 1:1 ratio of omega-6:omega-3). I can tell I’ve gone too long without fish fat when my arthritis starts to sneak up on me. The advice for reducing omega-6  across the board holds steady, of course, but everyone needs some form of fish fat. Another bonus is that it usually comes with healthy fish flesh, skin, bones , and sea minerals.
Omega-3 status is inversely associated with CRP in men . The higher the omega-3, the lower the systemic inflammation.
Daily fish oil for six months reduced inflammation in patients with metabolic syndrome and especially those with non-alcoholic fatty liver disease .
Delivering a “fish-fat” emulsion intravenously to patients with systemic inflammatory response syndrome had anti-inflammatory and liver-protective effects .
I was going to list grass-fed dairy , grass-fed beef/lamb, and pastured egg yolks as separate categories, but reconsidered. As I mentioned in my post on human interference factor , the unperturbed animals raised in relative harmony with their ancestry make the best, healthiest, least inflammatory food, while stressed-out animals raised in evolutionarily-novel conditions and on evolutionarily-novel feed make unhealthier and more inflammatory food. The important factor is that your animal fat  comes from pastured animals who ate grass, that the chickens who laid your eggs ate grass and bugs and grains/seeds lower in omega-6. Pastured ruminant and dairy fat contains more conjugated linoleic acid (CLA) (PDF ), an anti-inflammatory trans fatty acid, and pastured eggs contain more micronutrients and more omega-3 fats.
In one study, people with the highest levels of dairy-derived CLA in their tissues had the fewest heart attacks .
Eggs from chickens on a high-omega-6 diet were higher in omega-6, and they increased oxidized LDL in people who ate them .
Read this post  to learn why getting CLA from dairy and animal fat is better than getting it from supplements.
After treating red palm oil  as more of an intellectual curiosity than a culinary tool for years, it has really grown on me. Lately, I’ve been tossing cubed, steamed butternut squash with red palm oil, sea salt, black pepper, cayenne, and turmeric. It’s an interesting taste, but it definitely works (and it’s a good dish for vegetarians, too). Roasting veggies in it is good as well, as is a spoonful on top of those white Japanese sweet potatoes  (the starchier, not-so-sweet ones). Enough about taste, though – red palm oil is incredibly dense with antioxidants. Full spectrum vitamin E, CoQ10, vitamin A, and vitamin K, all incredibly important in maintaining antioxidant status, all make appearances.
When compared to the treasured monounsaturated fat, palm oil (high in saturated fat) greatly reduced oxidized LDL in humans . And that was refined palm oil. I suspect unrefined red palm oil, with all nutrients intact, would perform even better.
Pretty much every list of “Top 10 Anti-Inflammatory Foods” contains broccoli or cauliflower or kale or cabbage, but I thought I’d one-up those writers and include them all. I probably eat cruciferous vegetables five, sometimes seven times a week, mostly because they taste good but also because they contain helpful compounds like sulforaphane .
Broccoli lowered colonic inflammation in mice .
Red cabbage reduced oxidative stress and lipid peroxidation .
Sulforaphane reduced inflammation in arteries .
Although blueberries top most anti-inflammatory food lists (I’ve even seen Kaiser Permanente ads on the sides of buses that feature massive photos of glistening blueberries), and for good reason, I think the other berries get left out. Let’s face it, though – there isn’t really a bad berry out there. I don’t put a lot of faith in the superfruit phenomenon (though I’m sure goji berries are perfectly healthy), but berries are just solid guys to have in your diet. They’re delicious. They’re low in sugar. They’re high in surface area, which means lots of skin and all the antioxidants and phenolics that come with it (but go organic for that same reason). They’re colorful, which means lots of bioactive pigments.
Preliminary evidence suggests that blueberries, strawberries, and cranberries can ameliorate metabolic syndrome  through modulation of inflammation.
If you haven’t developed a taste for turmeric , I suggest you get on it. It is a potent anti-inflammatory spice, which protects against oxidation of dietary fats during cooking and against oxidative stress in the body after being eaten. You could go straight for the powerful stuff and simply take curcumin, the most active component of turmeric, but I’d suggest using the whole spice itself . That’s how it’s been used for thousands of years, and you’d miss out on the incredible flavor and color it provides otherwise. Somehow I doubt crumbling up curcumin pills would have the same culinary effect.
Turmeric beat both ginger and an anti-inflammatory drug for treating arthritis  (I’ve had similar results).
Turmeric also upregulates LDL receptor activity . If you remember from past posts on inflammation, poor LDL receptor activity can leave LDL particles open and vulnerable to oxidation  from inflammatory processes.
If you’re interested in reading more about the distinct health benefits of turmeric, check out my older post .
That’s what I’ve got. Dozens of other foods are perfectly healthy – staples, even – but the preceding foods are the ones that I find downright therapeutic. What about you? In the comment section, let me and everyone else hear about your favorite anti-inflammatory foods.
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 previous installments: http://www.marksdailyapple.com/what-is-inflammation/
 post-exercise inflammatory: http://www.marksdailyapple.com/the-relationship-between-exercise-and-inflammation-and-what-it-means-for-your-workouts/#axzz1kQPED9Le
 risk of blunting the positive effects of that workout: http://well.blogs.nytimes.com/2009/09/01/phys-ed-does-ibuprofen-help-or-hurt-during-exercise/
 inflammatory markers: http://www.marksdailyapple.com/how-to-tell-if-youre-inflamed-objective-and-subjective-inflammatory-markers/#axzz1kQPWDMNQ
 IF: http://www.marksdailyapple.com/fasting/#axzz1kQPOBB2H
 antinutrients in the bread: http://www.marksdailyapple.com/why-grains-are-unhealthy/
 potato: http://www.marksdailyapple.com/paleo-potatoes/#axzz1kQPl82Hc
 sprint: http://www.marksdailyapple.com/what-are-tabata-sprints/#axzz1kQPeyWdf
 dairy: http://www.marksdailyapple.com/dairy-intolerance/#axzz1kQOR3GgJ
 butter: http://www.marksdailyapple.com/grass-fed-butter/
 coffee: http://www.marksdailyapple.com/coffee-tea-caffeine-talk/#axzz1kQQ8vjQ6
 cheeses: http://www.marksdailyapple.com/cheese-unhealthy/#axzz1kQOmH3Hh
 yogurt: http://www.marksdailyapple.com/yogurt-mania/
 adult men with metabolic syndrome: http://www.ncbi.nlm.nih.gov/pubmed/21715516
 group of pregnant women: http://www.ncbi.nlm.nih.gov/pubmed/21936251
 dairy: http://www.marksdailyapple.com/dairy-insulin/
 Maasai-iest dairy: http://en.wikipedia.org/wiki/Maasai_people#Diet
 oysters: http://www.marksdailyapple.com/types-of-shellfish/#axzz1kQQhLGT6
 omega-3s: http://www.marksdailyapple.com/fish-oil-health-benefits/#axzz1kQQTIXhj
 salmon: http://www.marksdailyapple.com/salmon-factory-farm-vs-wild/#axzz1kQQbeR38
 omega-6: http://www.marksdailyapple.com/polyunsaturated-fat/#axzz1kQQ8vjQ6
 bones: http://www.marksdailyapple.com/cooking-with-bones/#axzz1kQQOPYhP
 inversely associated with CRP in men: http://www.ncbi.nlm.nih.gov/pubmed/22113248
 patients with metabolic syndrome and especially those with non-alcoholic fatty liver disease: http://www.ncbi.nlm.nih.gov/pubmed/22103753
 anti-inflammatory and liver-protective effects: http://www.ncbi.nlm.nih.gov/pubmed/22205554
 grass-fed dairy: http://www.marksdailyapple.com/grass-fed-butter/#axzz1kPwYowJ2
 human interference factor: http://www.marksdailyapple.com/human-interference-factor/#axzz1kPKpqtUA
 animal fat: http://www.marksdailyapple.com/yet-another-primal-primer-animal-fats/
 PDF: http://www.adsa.org/jointabs/iaafs108.pdf
 had the fewest heart attacks: http://www.ncbi.nlm.nih.gov/pubmed/20463040
 increased oxidized LDL in people who ate them: http://www.sciencedaily.com/releases/2011/08/110802162807.htm
 post: http://www.marksdailyapple.com/cla-supplements/#axzz1kQQqngRz
 red palm oil: http://www.marksdailyapple.com/palm-oil-nutrition/#axzz1kQR3Dtn1
 sweet potatoes: http://www.marksdailyapple.com/difference-yams-sweet-potatoes/#axzz1kQRBL5TU
 reduced oxidized LDL in humans: http://www.ncbi.nlm.nih.gov/pubmed/9756125
 sulforaphane: http://en.wikipedia.org/wiki/Sulforaphane
 colonic inflammation in mice: http://www.ncbi.nlm.nih.gov/pubmed/22113065
 reduced oxidative stress and lipid peroxidation: http://www.ncbi.nlm.nih.gov/pubmed/22228433
 reduced inflammation in arteries: http://www3.imperial.ac.uk/newsandeventspggrp/imperialcollege/newssummary/news_4-9-2009-15-8-42
 blueberries improved the related biomarkers: http://www.ncbi.nlm.nih.gov/pubmed/20660279
 malondialdehyde: http://en.wikipedia.org/wiki/Malondialdehyde
 blueberries, strawberries, and cranberries can ameliorate metabolic syndrome: http://www.ncbi.nlm.nih.gov/pubmed/22082311
 turmeric: http://www.marksdailyapple.com/health-benefits-turmeric/
 I’d suggest using the whole spice itself: http://www.marksdailyapple.com/creamy-turmeric-tea/
 for treating arthritis: http://www.ncbi.nlm.nih.gov/pubmed/21120596
 upregulates LDL receptor activity: http://www.ncbi.nlm.nih.gov/pubmed/18704882
 poor LDL receptor activity can leave LDL particles open and vulnerable to oxidation: http://www.marksdailyapple.com/how-might-inflammation-cause-heart-disease/#axzz1kQMfzLO6
 older post: http://www.marksdailyapple.com/health-benefits-turmeric/#axzz1kQMq8lbr
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