Marks Daily Apple
Serving up health and fitness insights (daily, of course) with a side of irreverence.
5 Apr

Resveratrol Does It Again

redwineSeriously, how can we not love this stuff? The potent little antioxidant has been hailed for years as anti-inflammatory, anti-atherogenic and even anti-cancer. And, as for the cancer part, the news just keeps getting better. Research out of the University of Rochester Medical Center shows that resveratrol is doubly effective in treating the exceptionally problematic pancreatic cancer.

[Resveratrol] can help destroy pancreatic cancer cells by reaching to the cell’s core energy source, or mitochondria, and crippling its function. The discovery is critical because, like the cell nucleus, the mitochondria contains its own DNA and has the ability to continuously supply the cell with energy when functioning properly. Stopping the energy flow theoretically stops the cancer. …The new study also showed that when the pancreatic cancer cells were doubly assaulted — pre-treated with the antioxidant, resveratrol, and irradiated — the combination induced a type of cell death called apoptosis, an important goal of cancer therapy. In fact, the research suggests resveratrol not only reaches its intended target, injuring the nexus of malignant cells, but at the same time protects normal tissue from the harmful effects of radiation.

via Science Daily

In the words of lead author, Paul Okunieff, “Resveratrol seems to have a therapeutic gain by making tumor cells more sensitive to radiation and making normal tissue less sensitive.” Resveratrol’s sabotage of the cell’s energy flow is also especially important for chemotherapy because it decreases the cell’s ability to simply “pump” out administered chemotherapy treatment.

The results themselves are fascinating and promising for those who face the difficulty of a pancreatic cancer diagnosis. But we also found ourselves talking about the broader context of this research: the power of a natural antioxidant as a complementary therapy with a conventional treatment.

We talk a lot about the role of exercise and diet/supplementation in prevention here, which makes sense. No one wants to find themselves faced with a critical diagnosis to begin with. But there’s a whole new branch of research unfolding that hopes to harness the best of traditional medicine and nutrient potential. We hope to bring you more along this vein in the future.

In the meantime, send us your thoughts and perspectives.

Homemade Flickr Photo (CC)

Further Reading:

Resveratrol Reduces Signs of Aging

Wine Prevents Cavities

Smart Fuel: Wine

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You want comments? We got comments:

Imagine you’re George Clooney. Take a moment to admire your grooming and wit. Okay, now imagine someone walks up to you and asks, “What’s your name?” You say, “I’m George Clooney.” Or maybe you say, “I’m the Clooninator!” You don’t say “I’m George of George Clooney Sells Movies Blog” and you certainly don’t say, “I’m Clooney Weight Loss Plan”. So while spam is technically meat, it ain’t anywhere near Primal. Please nickname yourself something your friends would call you.

  1. My only thought is where’s my corkscrew?

    Judy wrote on April 5th, 2008
  2. I’ll drink to that as well. I love it when something truly healthy is also a great way to indulge.

    Jen wrote on April 5th, 2008
  3. So what’s the effective dose of resveratol?? We all wanna know!

    Ryan wrote on April 5th, 2008
  4. Sadly, I’m probably going to have to let this great anti-oxidant be a infrequent one. I’d rather get my resveratrol from drinking wine instead of a capsule.

    But like others have also mentioned in comments on a previous post, I can’t ignore anymore that my tolerance for alcohol is so greatly reduced now. I hadn’t thought about it being due to LC, but that sounds reasonable. Unless it’s at at a party or somewhere really stimulating, one glass of wine at home in the evening will slow me down or put me to sleep on the sofa not long after dinner (& before the kitchen is cleaned up!). I really hated to think such a small amount of wine had that much effect, but now that I have gone a few weeks without wine with dinner (except some weekends), I can really see a difference. I’ve also lost just about 5 pounds from my middle section and I can’t think of any other reason for that.

    Anna wrote on April 5th, 2008
  5. Muscadine grapes are very high in resveratrol, and North Carolina Duplin muscadine wine is very affordable at $7.50 a bottle at my local supermarket. A four-ounce glass leaves a mildly sweet taste on the palate after dinner.

    Sonagi wrote on April 6th, 2008
  6. Are there any non-alcoholic sources of resveratrol?

    Moe wrote on April 6th, 2008
    • grapes and dark chocolate

      Erin wrote on July 6th, 2013
  7. Resveratrol can help you to lead a long and healthy life so says Dr. Oz.

    Resveratrol Supplements can help you control your weight naturally
    by increasing energy, reducing cravings, and limiting your appetite.
    According to Wikipedia, Consumer Lab, an independent dietary
    supplement and over the counter products evaluation organization,
    published a report on 13 November 2007 on the popular resveratrol
    supplements. The organization reported that there exists a wide range
    in quality, dose, and price among the 13 resveratrol products
    evaluated. The actual amount of resveratrol contained in the
    different brands range from 2.2mg for Revatrol, which claimed to have
    400mg of “Red Wine Grape Complex”, to 500mg for Biotivia.com Transmax,
    which is consistent with the amount claimed on the product’s label.
    Prices per 100mg of resveratrol ranged from less than $.30 for
    products made by Biotivia.com, jarrow, and country life, to a high of
    $45.27 for the Revatrol brand. None of the products tested were found
    to have significant levels of heavy metals or other contaminants.

    Derick wrote on April 6th, 2008
  8. I’m in Italy so a good bottle of red wine can be as little as 2 or 3 Euro ($3-5ish). Sign me up!

    Nancy S wrote on April 6th, 2008
  9. Nancy, I’m envious.. it seems wine is a lot cheaper everywhere in Europe. In Germany I could get a good S. African red wine for about 5 euro, the same bottle is $10-15 in the USA.

    Doug K wrote on April 9th, 2008
  10. I am definetly interested in this superior product but without the alcohol. To actually achieve the results they are talking about, you would need to consume a 1000 bottles of red wine a day. Impossible, right? So check out this website and you can find resveratrol here in its best consumable form.
    http://www.marketamerica.com/jeannebauer
    health & nutrition, find Isotonix Resveratrol.

    Jean wrote on April 10th, 2008
  11. The allometric scaling of metabolism models all the results obtained, and the reason for and limitations of caloric restriction’s effects on longevity. It is based upon the electrochemistry and thermodynamics of organic bonds of biomass. It also suggests extant ideas about mitochondrial energy generation and oxidants is preposterous, and that oxidative stress is not an issue in aging, that at the cellular level and smaller oxygen is not an electron donor,but instead an electron acceptor. That means no oxidation, but instead the generation of hydrogen peroxide, the creation of hydrogen and peptide bonds. This is about energy, not chemistry. And it bears upon the difference between basal and field metabolic rate. Resveratrol’s effects might work in a petri dish or on a lab rat, but they are harmful for large mammal, especially humans.

    Gregorio wrote on January 29th, 2012

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