Meet Mark

Let me introduce myself. My name is Mark Sisson. I’m 63 years young. I live and work in Malibu, California. In a past life I was a professional marathoner and triathlete. Now my life goal is to help 100 million people get healthy. I started this blog in 2006 to empower people to take full responsibility for their own health and enjoyment of life by investigating, discussing, and critically rethinking everything we’ve assumed to be true about health and wellness...

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Category: News

Dear Mark: That New Cholesterol-Lowering Drug Study

For today’s edition of Dear Mark, I’m answering one question. It’s a good one. A reader (many, actually) wrote in to get my opinion on the latest blockbuster cholesterol-lowering drug. A new study appears to show that the drug in question—Repatha—reduced LDL to unprecedented levels and protected patients against the primary cardiovascular disease endpoints they were measuring. What does it all mean? Should we all start taking Repatha?

Let’s dig into it:

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Weekend Link Love – Edition 445


Agriculture changed fatty acid conversion genes.

Elderly women who start taking statins have an increased risk of developing diabetes (just what they need!).

Climbing stairs for 3 minutes after each meal improves glucose control in type 2 diabetics.

Good sleep is like winning the lottery.


Episode 161: Helen Marshall: Host Elle Russ chats with Helen Marshall, who used Primal living to overcome debilitating digestive issues and now runs a global health coach service, produces a line of Primal Alternatives to the foods we used to love (and franchises it out to other people), all from 100 kangaroo-strewn acres in the Australian bush.


How hot baths and other forms of “passive heating” can have surprisingly beneficial effects.

Is 15,000 steps a better target than 10,000?

Why there’s nothing like a good storm.


Watch the precise moment a plankton eats plastic.

Woman dies after receiving IV turmeric for eczema. Just eat it, folks.

Australian researchers have reversed cell aging and extended a mouse’s lifespan (and healthspan) by 20% using an enzymatic precursor.


The NBA runs on PB&Js.

Cornell’s famous food lab is under fire for fabricated research.

The evolution of brain depictions.

In natural selection, “the fittest” doesn’t necessarily mean “the most ruthless and physically dominant.”

Spiders eat as much animal food as all the humans on earth.

Smoothies might make you fuller for longer.


Ticket deal you should get on: Paleo f(x) 2017 is coming, and the organizers have a ticket flash sale for early adopters going through March 31.

Two views on a fundamentally “human” ability—empathy: Paul Bloom’s (“against”) and a new paper from Penn State.

Story I loved: 91-year-old woman gets cancer diagnosis, skips chemo, decides to go on epic 12-month road trip.

Stat I didn’t like: Today’s men are weaker than their fathers were at the same age.

I couldn’t stop laughing: Fake strongmen on local morning news shows.



One year ago (Mar 26– Apr 1)


“I picked up 21 chicks that walked through my yard last April and put them in a cage (don’t think anyone missed them) but it wasn’t until they were freed and allowed to start finding their own food and spaces that they started laying. Now they sleep in the pomerac tree and eat anything they can find or that’s tossed out the kitchen window. We still feed them occasionally with the factory feed but that’s more to ensure that they can still be tempted back into the coop in the event that they stop laying and need to be curried instead.”

– Interesting thoughts from Stephen Sankarsingh.

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Weekend Link Love – Edition 444


Stress alters gut bacteria (in mice). Altering it back improves stress resilience.

How space affects the brain.

Alcohol may not actually help fight heart disease.

Probiotics increase polyphenol absorption.

Rituals improve kids’ executive functioning.

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The Emerging Science of Electrostimulation

As a Primal lifer, I recognize that purity has a certain allure, just as I know it has its decided limitations. I frequently find myself wondering, “Would my paleolithic forebears have done/said/eaten that?” and choosing my course of action based on this line of educated assumption. It’s the WWGD lens on modern living. In a Primal-perfect world, that would be sufficient to ensure continued health and happiness. But things don’t always work out as planned…

Let’s say you hurt your back in an unfortunate turn of events. Primal dictates can certainly help with healing you over the long term, but if you want to get out of bed in the morning you’re likely stuck with the doc’s prescriptions. Similar situation if you’ve suffered physical damage to your eyesight, hearing, brain, or any number of your less robust anatomical sectors. Sometimes to get life done, you’ve just got to suck it up and take your meds.

It’s possible, however, that this may soon change. In my recent post on the vagus nerve, I touched upon an emerging curiosity in the medical world: electroceuticals. While still in comparative infancy, electroceuticals may end up revolutionizing a health care model currently dominated by the drug industry.

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Weekend Link Love – Edition 443


Drinking blueberry concentrate boosts cognitive function in older folks.

Americans are having less sex.

“Surprisingly, plasma Lp(a) concentrations increased in a stepwise fashion as SFA was reduced.”

Prebiotics help overweight and obese kids control appetite.

Social eating—especially at night—facilitates social bonding.

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Join Me and Melissa Hartwig This Saturday

Are you headed to the Expo West this weekend? Join me this Saturday, March 11th, from 12:00-1:00 P.M. PST when I’m teaming up with my friend, Melissa Hartwig of Whole30®, for a full hour of Meet and Greet (booth H1013). And just to add to the fun, the first 50 people who show up will walk away with a free Primal Kitchen® Whole30® Approved item.

And no worries if you can’t make it to the Expo. Join Melissa and I on the Primal Kitchen Facebook page for a Facebook Live chat at 11:45 A.M. PST this Saturday, when we’ll talk about the show and my brand new Whole30® Approved products—Egg-Free Mayo as well as Green Goddess and Caesar Dressings.  You won’t want to miss it.

I’ll look forward to meeting the Primal crowd this Saturday. Grok on, everybody!

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