Let me introduce myself. My name is Mark Sisson. I’m 63 years young. I live and work in Malibu, California. In a past life I was a professional marathoner and triathlete. Now my life goal is to help 100 million people get healthy. I started this blog in 2006 to empower people to take full responsibility for their own health and enjoyment of life by investigating, discussing, and critically rethinking everything we’ve assumed to be true about health and wellness...Tell Me More
Take your average guy or gal that decides they’re committed to finally losing that extra weight that’s crept on over the years. They’re going to eat healthy (primally, of course), start working out, and stop all the nonsense they know to be unhealthy. This might be you.
A few days go by, then a week. The scale is budging, but barely. “This is going to take forever! How long is this going to take?” We all want instant results, right? Well, what is realistic? What is safe? What is effective? And what can you expect when you attempt to lose excess body fat and reach your ideal body composition?
Everyone knows that slow, gradual weight loss produces the best long-term results and fast weight loss is unsafe and unhealthy. People you know have probably clucked “Oh, you’re losing weight fast now with that low-carb fad diet, but just wait a few weeks and it’ll all come rushing back!” And when you go somewhere like the CDC’s weight loss page, they pat your head for “want[ing] to lose it very quickly” and reassure you that “people who lose weight gradually and steadily are more successful at keeping it off.” It’s become an article of faith that slow and steady weight loss wins the race.
But is it actually true?
I searched the literature for support of this widely-accepted weight loss truth. If folks like the Center for Disease Control were saying it, there had to be some evidence for it. Right?
I came up empty. What little evidence I could find seemed to support the opposite contention: that rapid initial weight loss is associated with better long term weight maintenance than slower weight loss. Just look:
Across most of the available literature, slow and steady did not win the race. The hare usually beat the tortoise. This actually makes sense. Why is the ancestral health community so strong? Why does this site attract so many readers? In part, because of the ease, simplicity, and early efficacy of this way of eating. Right off the bat (or in just 21 days), you lose weight, feel better, and regain lost energy. Why wouldn’t you keep doing it? You’re more likely to stick with a diet if you’re wildly successful right away.
Okay, okay. But is rapid weight loss safe?
It depends on who you are.
If you’re obese, rapid weight loss is safe, since as much as 87% of the total weight you lose will be body fat. And just as dietary fat is an excellent fuel source that burns cleanly, the animal fat hanging off your body is good to burn. That’s why rapid weight loss in the obese is consistently associated with improved health markers. Insulin sensitivity increases and belly fat decreases. Blood lipids normalize. Testosterone increases and sexual function is restored. Oxidative stress biomarkers are reduced. All sorts of wonderful things happen when you’re overweight or obese and start losing weight.
If you’re lean, rapid weight loss looks a little different. The leaner you are, the more muscle mass you’ll lose during weight loss and the more negative effects you’ll accrue. An extreme example of this is the bodybuilder preparing for competition. He’s reducing calories. He’s exercising. He’s doing everything he can to drop weight as quickly as possible. And in dropping from 14.8% body fat to 4.5%, he loses strength, his testosterone plummets, and his mood worsens — the opposite of what happens to the obese when they drop weight fast.
Another population for whom rapid weight loss might be contraindicated is the elderly. If you’re elderly, rapid weight loss is usually associated with illness and accelerated muscle loss, and it’s a frequent complication of Alzheimer’s disease. Slower weight loss using a diet rich in protein (to stave off muscle loss) and regular physical activity is a better option for older people.
It also depends on how you do it. Let’s look at some of the methods used to cause rapid weight loss.
Athletes who need to make weight to qualify for competition, like MMA fighters or bodybuilders, often do so by quickly dropping water weight. They’ll go jogging in full black sweatsuits. They’ll sit in saunas. They’ll remove all salt from their diet (since sodium helps us retain water). They’ll go super low-carb (since stored glycogen brings water along for the ride). They’ll take hot baths and stop drinking water altogether on the day of the weigh-in. That’s how a fighter who normally walks around at 195 pounds can qualify for the 170 pound division — by dehydrating himself.
Verdict: Not safe. Dehydration impairs physical performance, cognitive function, and connective tissue elasticity. Plus, it’s literally just water weight that will come screaming back once you start eating carbs, salt, and drinking water again.
This might be the most common method people employ to achieve fast weight loss: eat barely anything. And there are studies supporting the efficacy of very low-calorie dieting (VLCD), but when your average person with weight to lose hears that and just stops eating (usually supplemented with lots of cardio), it’s disastrous. Clinical VLCDs have very specific guidelines. Before patients are selected, they undergo a physical and go over their medical history. Once on the diet, they receive counseling, supplements, premade food (often liquid), and regular checkups to identify nutrient deficiencies and side effects. They’re meant for the obese, not someone who wants to lose a few stubborn inches off their belly.
Verdict: Safe, but you’d better know what you’re doing. Professional supervision is probably a good idea if you intend on making this work long-term.
Protein-sparing modified fasts (PSMFs) are a type of very low-calorie diet, but calories aren’t the express focus; getting enough protein and then stopping is the focus. You eat as much protein, preferably from animal sources, as you require to curb loss of lean mass and maximize fat loss, then add heaps of low-carb vegetables. PSMFs are high-protein, low-carb, and low-fat diets. A PSMF might look this:
In the fitness/weight loss community, people will typically maintain this for 1-2 weeks, then do a refeed and hop back on it, or resume a more normal diet. Clinical use of the PSMF in severely obese people usually lasts longer than one or two weeks and is quite effective:
Every study I could find on PSMFs found they worked and were safe, with some caveats:
In obese teens, a 3-month long PSMF supplemented with potassium, calcium, and magnesium resulted in weight loss and maintenance of normal serum concentrations of the supplemented minerals. But when researchers looked at red blood cell levels of the minerals — which offers a more accurate glimpse of mineral status than serum level — they found that RBC magnesium had plummeted. It’s likely that other micronutrient-related biomarkers could also suffer.
Verdict: Safe and effective, provided you don’t remain on the diet for too long. Extended PSMFs are more likely to cause harm and nutrient deficiencies (that may not show up in standard serum tests) than shorter PSMF bursts. Obese people in clinical settings with professional support can probably safely benefit from longer PSMFs, but the average Primal reader just trying to lean out a bit or get over a plateau should stick to 1-2 weeks.
In the population most in need of safe, effective weight loss — the millions of insulin-resistant obese and overweight individuals who do not participate in clinical weight loss trials helmed by doctors and technicians and supported by supplements and formulated diets — a basic low-carb, high-fat diet is the simplest and most effective method. Comparisons between ad libitum (where you eat until sated) low-carb diets and calorie-restricted (where you weigh and measure) diets find that the former result in faster weight loss.
Low-carb, high-fat approaches also sidestep another potential downside to rapid fat loss in general: the risk of gallstone formation. Research shows that adding some fat in the diet to promote gallbladder emptying takes care of the gallstone problem. One study found that 4 of 6 subjects on a 520 calorie liquid low-fat diet developed gallstones, while none of the 7 subjects on a 900 calorie liquid diet with 30 grams of fat developed them, even though both diets resulted in the same amount of weight loss.
One potential downside of rapid weight loss are elevations in liver enzymes. The rise is usually transient, resolving shortly after cessation of the diet, and it seems to happen more often in women than men. But the macronutrient ratio is perhaps the biggest determinant. When these very low-calorie diets are high in carbohydrates, liver enzymes are higher. When the diet is carb-restricted, the liver enzymes are lower.
Verdict: Safe and effective.
If there’s a neat and tidy answer (and there never is in a topic as complex as human physiology), it’s this: rapid weight loss is safe as long as you’re losing (mostly) fat and not lean muscle mass. If you’re dropping weight quickly (or slowly!) but you feel good, your physical performance is improving or staying the same, and you’re losing inches from the waist, your weight loss is probably mostly fat. If you’re dropping weight quickly but troublesome side effects occur, your weight loss may be drawing on more lean mass than you’d like, and you should probably slow down. Weight loss should feel good.
There’s another commonality among all the “crash” diets that end up leading to long term maintenance: they combine rapid weight loss and education. It shouldn’t just change what you put in your mouth, but how you think about what you put in your mouth. Without learning about food and how it affects you and how to eat long term in the real world, the weight’s just going to come roaring back.
With the Primal Blueprint, I’ve tried to pair education with results for a sustainable way of eating and living. There are other ways to get there, as I’ve mentioned above, but this one seems to work well for nearly everyone I know that’s tried it.
Thanks for reading, everyone. I’m curious about your thoughts on rapid weight loss.
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