Comments on: Gene Expression: Location, Location, Location http://www.marksdailyapple.com/genetic-expression-geography/ Serving up health and fitness insights (daily, of course) with a side of irreverence. Sat, 21 Nov 2009 17:00:39 -0700 http://wordpress.org/?v=2.8.1 hourly 1 By: Control Your Lifestyle, Control Your Genes | Mark's Daily Apple http://www.marksdailyapple.com/genetic-expression-geography/#comment-401454 Control Your Lifestyle, Control Your Genes | Mark's Daily Apple Wed, 10 Jun 2009 21:01:17 +0000 http://www.marksdailyapple.com/genetic-expression-geography/#comment-401454 [...] Gene Expression: Location, Location, Location [...] [...] Gene Expression: Location, Location, Location [...]

]]> By: Carl http://www.marksdailyapple.com/genetic-expression-geography/#comment-338163 Carl Sun, 29 Mar 2009 10:19:40 +0000 http://www.marksdailyapple.com/genetic-expression-geography/#comment-338163 Your blog is so informative … keep up the good work!!!!

]]> By: Mark’s Daily Apple » Blog Archive » Metabolic Fingerprinting http://www.marksdailyapple.com/genetic-expression-geography/#comment-75095 Mark’s Daily Apple » Blog Archive » Metabolic Fingerprinting Fri, 16 May 2008 15:25:25 +0000 http://www.marksdailyapple.com/genetic-expression-geography/#comment-75095 [...] Gene Expression: Location, Location, Location [...] [...] Gene Expression: Location, Location, Location [...]

]]> By: Mark’s Daily Apple » Blog Archive » Dear Mark: Gene Expression http://www.marksdailyapple.com/genetic-expression-geography/#comment-56489 Mark’s Daily Apple » Blog Archive » Dear Mark: Gene Expression Mon, 28 Apr 2008 17:05:52 +0000 http://www.marksdailyapple.com/genetic-expression-geography/#comment-56489 [...] received tons of emails from last week’s Gene Expression: Location, Location, Location post. Thanks to everybody for their feedback and questions. In the comment section of last week’s [...] [...] received tons of emails from last week’s Gene Expression: Location, Location, Location post. Thanks to everybody for their feedback and questions. In the comment section of last week’s [...]

]]> By: Mark Sisson http://www.marksdailyapple.com/genetic-expression-geography/#comment-56084 Mark Sisson Sat, 26 Apr 2008 20:00:17 +0000 http://www.marksdailyapple.com/genetic-expression-geography/#comment-56084 This is the essence of my "Primal Blueprint". All we really have to do to be healthy, fit, energetic, happy, productive, etc...is find those behaviors that promote gene expression (or turn it off in some cases) in the direction of health versus sickness. In most cases, this means emulating what our ancestors did prior to agriculture. It's really a simple list of rules, but it's very difficult for some people to grasp or to follow within the context of this complex, industrialized, information-glutted, hedonistic, instant gratification society. This is the essence of my “Primal Blueprint”. All we really have to do to be healthy, fit, energetic, happy, productive, etc…is find those behaviors that promote gene expression (or turn it off in some cases) in the direction of health versus sickness. In most cases, this means emulating what our ancestors did prior to agriculture. It’s really a simple list of rules, but it’s very difficult for some people to grasp or to follow within the context of this complex, industrialized, information-glutted, hedonistic, instant gratification society.

]]> By: thescientistofhealth http://www.marksdailyapple.com/genetic-expression-geography/#comment-56073 thescientistofhealth Sat, 26 Apr 2008 19:16:47 +0000 http://www.marksdailyapple.com/genetic-expression-geography/#comment-56073 What is most interesting is the possibility that the same genes and proteins that cause disease states like insulin resistance are also the same genes and proteins that are upregulated following exercise. A protein by the name of JNK comes to mind. With aging and insulin resistance, JNK is elevated and basically functions to shut off the insulin receptor --thus causing insulin resistance. Following exercise, insulin resistant populations show reduced JNK activation. The same protein in healthy young adults has increased activated after exercise, and greatly improved insulin sensitivity. Interestingly, if you compare older/insulin resistant JNK activation to that of younger healthy people, they end up with the same relative level of activation after exercise. Its just fascinating to me that the same protein can cause insulin resistance or actually reverse it depending on the population of interest. What is most interesting is the possibility that the same genes and proteins that cause disease states like insulin resistance are also the same genes and proteins that are upregulated following exercise.

A protein by the name of JNK comes to mind. With aging and insulin resistance, JNK is elevated and basically functions to shut off the insulin receptor –thus causing insulin resistance. Following exercise, insulin resistant populations show reduced JNK activation.

The same protein in healthy young adults has increased activated after exercise, and greatly improved insulin sensitivity.

Interestingly, if you compare older/insulin resistant JNK activation to that of younger healthy people, they end up with the same relative level of activation after exercise.

Its just fascinating to me that the same protein can cause insulin resistance or actually reverse it depending on the population of interest.

]]> By: Mark Sisson http://www.marksdailyapple.com/genetic-expression-geography/#comment-55700 Mark Sisson Sat, 26 Apr 2008 00:12:55 +0000 http://www.marksdailyapple.com/genetic-expression-geography/#comment-55700 Thanks, Doc. I'll stop by to get my scrubs! We appreciate the nod. Thanks, Doc. I’ll stop by to get my scrubs! We appreciate the nod.

]]> By: Dr. Incognito http://www.marksdailyapple.com/genetic-expression-geography/#comment-55677 Dr. Incognito Fri, 25 Apr 2008 22:59:01 +0000 http://www.marksdailyapple.com/genetic-expression-geography/#comment-55677 Mark, I chose this post as the winner of this week's Redscrubs Weekly Wrap-up by redscrubs.com. You get two things with this dubious honor: Recognition and hopefully some additional traffic from other medical blog readers who might not ordinarily visit your site, and a free pair of red scrubs. Yes, they're free and yes they are red!:) There is no catch. I am not trying to sell you anything...I promise. This is simply our way of recognizing and giving some sort of award to those who take the time to get involved in the medical blogging community. So, if you'd like your free scrubs, just send me your size and mailing info. by this coming Wednesday. Otherwise, the scrubs go to the first runner up on the honorable mention list. Congrats, Dr. Incognito Mark,
I chose this post as the winner of this week’s Redscrubs Weekly Wrap-up by redscrubs.com. You get two things with this dubious honor: Recognition and hopefully some additional traffic from other medical blog readers who might not ordinarily visit your site, and a free pair of red scrubs.

Yes, they’re free and yes they are red!:) There is no catch. I am not trying to sell you anything…I promise. This is simply our way of recognizing and giving some sort of award to those who take the time to get involved in the medical blogging community. So, if you’d like your free scrubs, just send me your size and mailing info. by this coming Wednesday. Otherwise, the scrubs go to the first runner up on the honorable mention list.

Congrats,
Dr. Incognito

]]> By: Mark Sisson http://www.marksdailyapple.com/genetic-expression-geography/#comment-55609 Mark Sisson Fri, 25 Apr 2008 18:39:20 +0000 http://www.marksdailyapple.com/genetic-expression-geography/#comment-55609 Ed, You got it. Evrything we do affects gene expression every second of every day. The only real differences among us are simply the ranges or degrees of possible gene expression for any one particular gene locus or set of related loci. That means that a 5'10" person with "perfect mesomorphic tendencies" can still range in weight from 110 to 500 pounds depending on environmental influences on gene expression...or an ectomorph from 85 to 275 pounds, etc. Not all women with BRCA1 or BRCA2 get breast cancer even though their risk is far greater, etc etc. Ed,

You got it. Evrything we do affects gene expression every second of every day. The only real differences among us are simply the ranges or degrees of possible gene expression for any one particular gene locus or set of related loci. That means that a 5′10″ person with “perfect mesomorphic tendencies” can still range in weight from 110 to 500 pounds depending on environmental influences on gene expression…or an ectomorph from 85 to 275 pounds, etc. Not all women with BRCA1 or BRCA2 get breast cancer even though their risk is far greater, etc etc.

]]> By: Ed http://www.marksdailyapple.com/genetic-expression-geography/#comment-55589 Ed Fri, 25 Apr 2008 17:26:41 +0000 http://www.marksdailyapple.com/genetic-expression-geography/#comment-55589 It might be useful to augment this post with some concrete examples of gene expression. For instance, something like insulin resistance versus insulin sensitivity would, as I understand it, be a result of gene expression. Given a normal genetic endowment for metabolism, one may become insulin resistant or insulin sensitive based on environmental factors such as diet and exercise. The same for body composition, skin tone, cardio-vascular capacity, strength, immunity, and on and on. We aren't slaves to our genes. Our genetic endowment permits of various outcomes that we can influence through the choices we make. That's what I take away from the concept of gene expression. It might be useful to augment this post with some concrete examples of gene expression. For instance, something like insulin resistance versus insulin sensitivity would, as I understand it, be a result of gene expression. Given a normal genetic endowment for metabolism, one may become insulin resistant or insulin sensitive based on environmental factors such as diet and exercise. The same for body composition, skin tone, cardio-vascular capacity, strength, immunity, and on and on. We aren’t slaves to our genes. Our genetic endowment permits of various outcomes that we can influence through the choices we make. That’s what I take away from the concept of gene expression.

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