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	<title>Comments on: Dear Mark: Gene Expression</title>
	<atom:link href="http://www.marksdailyapple.com/gene-expression-2/feed/" rel="self" type="application/rss+xml" />
	<link>http://www.marksdailyapple.com/gene-expression-2/</link>
	<description>Serving up health and fitness insights (daily, of course) with a side of irreverence.</description>
	<pubDate>Fri, 08 Aug 2008 01:11:39 +0000</pubDate>
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		<item>
		<title>By: Mark&#8217;s Daily Apple &#187; Blog Archive &#187; Epigenetics and Depression</title>
		<link>http://www.marksdailyapple.com/gene-expression-2/#comment-77119</link>
		<dc:creator>Mark&#8217;s Daily Apple &#187; Blog Archive &#187; Epigenetics and Depression</dc:creator>
		<pubDate>Tue, 20 May 2008 18:51:41 +0000</pubDate>
		<guid isPermaLink="false">http://www.marksdailyapple.com/gene-expression-2/#comment-77119</guid>
		<description>[...] stuff really floats our boat. The last few weeks we’ve brought you a Dear Mark primer on gene expression as well as news on recent studies examining the role of lifestyle/environment on genetic [...]</description>
		<content:encoded><![CDATA[<p>[...] stuff really floats our boat. The last few weeks we’ve brought you a Dear Mark primer on gene expression as well as news on recent studies examining the role of lifestyle/environment on genetic [...]</p>
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		<title>By: Mark&#8217;s Daily Apple &#187; Blog Archive &#187; Metabolic Fingerprinting</title>
		<link>http://www.marksdailyapple.com/gene-expression-2/#comment-69737</link>
		<dc:creator>Mark&#8217;s Daily Apple &#187; Blog Archive &#187; Metabolic Fingerprinting</dc:creator>
		<pubDate>Sat, 10 May 2008 15:37:56 +0000</pubDate>
		<guid isPermaLink="false">http://www.marksdailyapple.com/gene-expression-2/#comment-69737</guid>
		<description>[...] Dear Mark: Gene Expression [...]</description>
		<content:encoded><![CDATA[<p>[...] Dear Mark: Gene Expression [...]</p>
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		<title>By: Mark Sisson</title>
		<link>http://www.marksdailyapple.com/gene-expression-2/#comment-56599</link>
		<dc:creator>Mark Sisson</dc:creator>
		<pubDate>Tue, 29 Apr 2008 00:02:20 +0000</pubDate>
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		<description>Tina,Tim,

That's the same erroneous assumption we discussed last month. Humans may be exhibiting a widening range of SNPs and slight gene variances, but that does not mean that we are evolving at a faster rate. It just means that mutations and changes are not selected out and that normal "drift" happens at a greater rate due to sheer numbers. In fact, since there is no longer any effective selection pressure on our species (no predators, no real threat of starvation forcing us to adapt anew) and a nearly unlimited ability to reproduce, we have ceased to evolve in the truest Darwinian sense. The only two possible traits that appear to have been somewhat selected for in the past 10,000 years are a continued lactose tolerance among some herders (which isn't even really an adaptation when you realize that we are all lactose tolerant through much of childhood - and when you also look at other possible factors like the effect of WGA on gut turnover) and a possible increase in salivary amylase production I hear mentioned occasionally (pretty weak). That's it. Everything else on us is supposed to work exactly as it evolved through the first 60,000,000 years - of which 2 1/2 million was "human" evolution, and up until 10,000 years ago, after which time there was no more selection pressure...just bad food choices, too-close living conditions, industrialization and the Internet.

That's why the Modern Blueprint so closely emulates the Primal Blueprint. Give me one example of a Modern lifestyle behavior or food that would differ (in principle) from a Primal behavior.</description>
		<content:encoded><![CDATA[<p>Tina,Tim,</p>
<p>That&#8217;s the same erroneous assumption we discussed last month. Humans may be exhibiting a widening range of SNPs and slight gene variances, but that does not mean that we are evolving at a faster rate. It just means that mutations and changes are not selected out and that normal &#8220;drift&#8221; happens at a greater rate due to sheer numbers. In fact, since there is no longer any effective selection pressure on our species (no predators, no real threat of starvation forcing us to adapt anew) and a nearly unlimited ability to reproduce, we have ceased to evolve in the truest Darwinian sense. The only two possible traits that appear to have been somewhat selected for in the past 10,000 years are a continued lactose tolerance among some herders (which isn&#8217;t even really an adaptation when you realize that we are all lactose tolerant through much of childhood - and when you also look at other possible factors like the effect of WGA on gut turnover) and a possible increase in salivary amylase production I hear mentioned occasionally (pretty weak). That&#8217;s it. Everything else on us is supposed to work exactly as it evolved through the first 60,000,000 years - of which 2 1/2 million was &#8220;human&#8221; evolution, and up until 10,000 years ago, after which time there was no more selection pressure&#8230;just bad food choices, too-close living conditions, industrialization and the Internet.</p>
<p>That&#8217;s why the Modern Blueprint so closely emulates the Primal Blueprint. Give me one example of a Modern lifestyle behavior or food that would differ (in principle) from a Primal behavior.</p>
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		<title>By: Tina</title>
		<link>http://www.marksdailyapple.com/gene-expression-2/#comment-56581</link>
		<dc:creator>Tina</dc:creator>
		<pubDate>Mon, 28 Apr 2008 23:29:53 +0000</pubDate>
		<guid isPermaLink="false">http://www.marksdailyapple.com/gene-expression-2/#comment-56581</guid>
		<description>"The “primal” part comes from the recognition that our basic human DNA is relatively unchanged from the past 10,000 years."

Which is where your Primal arguments fall to shambles since this simply isn't true. Genetically we have little in common with late Paleo people, let alone earlier ones. Evolution is known to occur much faster than you give it credit for and we are not stuck in the mold as you imply. Genetic expression adds even greater options for diversity, which you rightly bring up. But you should focus on a Modern Blueprint instead of the fantasy stuff.</description>
		<content:encoded><![CDATA[<p>&#8220;The “primal” part comes from the recognition that our basic human DNA is relatively unchanged from the past 10,000 years.&#8221;</p>
<p>Which is where your Primal arguments fall to shambles since this simply isn&#8217;t true. Genetically we have little in common with late Paleo people, let alone earlier ones. Evolution is known to occur much faster than you give it credit for and we are not stuck in the mold as you imply. Genetic expression adds even greater options for diversity, which you rightly bring up. But you should focus on a Modern Blueprint instead of the fantasy stuff.</p>
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		<title>By: JohnSon</title>
		<link>http://www.marksdailyapple.com/gene-expression-2/#comment-56560</link>
		<dc:creator>JohnSon</dc:creator>
		<pubDate>Mon, 28 Apr 2008 22:52:11 +0000</pubDate>
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		<description>As more research is done and as this information becomes available I'd be interested to hear more about what one can do to achieve a desired physical effect. Or is all this going to do is tell us what we already know? Eat well, sleep well, stay active etc. It would be cool to find previously unknown body hacks. Though, I suppose some of the stuff MDA has already published is sort of body hack material... e.g. natural production of HGH, chronic cardio troubles etc.</description>
		<content:encoded><![CDATA[<p>As more research is done and as this information becomes available I&#8217;d be interested to hear more about what one can do to achieve a desired physical effect. Or is all this going to do is tell us what we already know? Eat well, sleep well, stay active etc. It would be cool to find previously unknown body hacks. Though, I suppose some of the stuff MDA has already published is sort of body hack material&#8230; e.g. natural production of HGH, chronic cardio troubles etc.</p>
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	<item>
		<title>By: Cindy</title>
		<link>http://www.marksdailyapple.com/gene-expression-2/#comment-56557</link>
		<dc:creator>Cindy</dc:creator>
		<pubDate>Mon, 28 Apr 2008 22:42:49 +0000</pubDate>
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		<description>That makes so much sense, I'm tired of hearing my friends blame their ailments on "bad genes." Because I'm a bit a naturalist, I'll use the garden metaphor. It's not the seeds you're given, it's how you nurture them.</description>
		<content:encoded><![CDATA[<p>That makes so much sense, I&#8217;m tired of hearing my friends blame their ailments on &#8220;bad genes.&#8221; Because I&#8217;m a bit a naturalist, I&#8217;ll use the garden metaphor. It&#8217;s not the seeds you&#8217;re given, it&#8217;s how you nurture them.</p>
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