The first intervention for hypertensive treatment common to all fields of medicine is to incorporate diet and lifestyle changes, such as increased exercise, increased consumption of magnesium and potassium, and a low-sodium diet. Beyond these first steps to set the foundation, the realm of specific supplementation protocols are individually customized and frequently include coenzyme Q10 (CoQ10), hawthorn (Crataegus spp.) berry extract, olive (Olea europaea) leaf extract, garlic (Allium sativum), coleus (Coleus forskohlii), omega-3 fatty acids, and L-arginine. Clinical practice routinely demonstrates that a multifactorial approach of lifestyle changes combined with appropriate supplements can make a significant impact on hypertension. The ‘‘bottom line’’ when creating a therapeutic intervention for a patient who has hypertension is to achieve a normotensive state safely with as few side effects as possible, while supporting overall cardiovascular health in a manner that is sustainable for a lifetime.