CAFO cows are fed GMO grains (not enough time elapsed to know what that will cause), growth hormones (girls menstruate about two years earlier than 50 years ago), and subtherapeutic antibiotics (here a superbug, there a superbug). IOW, the meat growers know the growth hormones often cause illness, so they give cattle antibiotics through most of their lives to keep that at bay.
That is pretty much what is concentrated in the fat of CAFO beef.
"Right is right, even if no one is doing it; wrong is wrong, even if everyone is doing it." - St. Augustine