Not really. the effects of excess FFAs on the insulin receptor mediated signaling pathways in adipose tissue, liver, and skeletal muscle as well as the pro-inflammatory status induced by the toxic effects of excess FFAs in the liver and adipose tissues cause insulin resistance. The FFA induced down regulation of insulin signaling pathways results in activation of several kinases involved in stress response; such as JNK, and suppressors of cytokine signaling-3. JNK activity is also regulated by FFAs and is an important regulator of insulin resistance.
Originally Posted by dilberryhoundog
See: Randle cycle
Time is passing so quickly. Right now, I feel like complaining to Einstein. Whether time is slow or fast depends on perception. Relativity theory is so romantic. And so sad.