this is because aspirin could reduce renal blood and impair renals because of its inhibition of COX2, which supports renal perfusion. it's mostly seen in elderly with already established renal disease. this is where vitamin k, and potassium and sodium balance come in. given that, aspirin also binds weakly to COX2, and has to compete with arachidonic acid for conversion, and because the cyclooxygenase active site is very large in COX2, aspirin doesn't fit well so the trans-acetylation at COX2 is reduced. its selective inhibition of inflammatory secretions of prostacyclins is why aspirin is recommended.
Originally Posted by Hotmail
Longing is the agony of the nearness of the distant