That's an excellent study and review. Thanks
It has become clear that most, if not all, typically Western chronic illnesses find their primary cause in an unhealthy lifestyle and that systemic low grade inflammation is a common denominator. From an evolutionary point of view, the current conflict between environment and our Paleolithic genome traces back to our brain growth and the ensuing intimate relationship between inflammation and metabolism. The present disbalance between inflammatory and anti-inflammatory stimuli does not originate from a single cause and can consequently also not be solved by a single “magic bullet”. Resolution of the conflict between environment and our ancient genome might be the only effective manner to arrive at “healthy aging” and to achieve this objective we might have to return to the lifestyle of the Paleolithic era according to the culture of the 21st century  and .
"When the search for truth is confused with political advocacy, the pursuit of knowledge is reduced to the quest for power." - Alston Chase