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Thread: The journal of nutritional biochemistry has an interesting July article. page

  1. #1
    Legbiter's Avatar
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    The journal of nutritional biochemistry: Go Paleo or die.

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    Lifestyle and nutritional imbalances associated with Western diseases: causes and consequences of chronic systemic low-grade inflammation in an evolutionary context

    Abstract
    In this review, we focus on lifestyle changes, especially dietary habits, that are at the basis of chronic systemic low grade inflammation, insulin resistance and Western diseases. Our sensitivity to develop insulin resistance traces back to our rapid brain growth in the past 2.5 million years. An inflammatory reaction jeopardizes the high glucose needs of our brain, causing various adaptations, including insulin resistance, functional reallocation of energy-rich nutrients and changing serum lipoprotein composition. The latter aims at redistribution of lipids, modulation of the immune reaction, and active inhibition of reverse cholesterol transport for damage repair. With the advent of the agricultural and industrial revolutions, we have introduced numerous false inflammatory triggers in our lifestyle, driving us to a state of chronic systemic low grade inflammation that eventually leads to typically Western diseases via an evolutionary conserved interaction between our immune system and metabolism. The underlying triggers are an abnormal dietary composition and microbial flora, insufficient physical activity and sleep, chronic stress and environmental pollution. The disturbance of our inflammatory/anti-inflammatory balance is illustrated by dietary fatty acids and antioxidants. The current decrease in years without chronic disease is rather due to “nurture” than “nature,” since less than 5% of the typically Western diseases are primary attributable to genetic factors. Resolution of the conflict between environment and our ancient genome might be the only effective manner for “healthy aging,” and to achieve this we might have to return to the lifestyle of the Paleolithic era as translated to the 21st century culture.
    The whole paper is a good read as well, especially the potshots they take at single-nutrient studies.
    Last edited by Legbiter; 07-02-2013 at 03:59 PM.

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    That's an excellent study and review. Thanks

    9. Conclusions

    It has become clear that most, if not all, typically Western chronic illnesses find their primary cause in an unhealthy lifestyle and that systemic low grade inflammation is a common denominator. From an evolutionary point of view, the current conflict between environment and our Paleolithic genome traces back to our brain growth and the ensuing intimate relationship between inflammation and metabolism. The present disbalance between inflammatory and anti-inflammatory stimuli does not originate from a single cause and can consequently also not be solved by a single “magic bullet”. Resolution of the conflict between environment and our ancient genome might be the only effective manner to arrive at “healthy aging” and to achieve this objective we might have to return to the lifestyle of the Paleolithic era according to the culture of the 21st century [16] and [322].
    "When the search for truth is confused with political advocacy, the pursuit of knowledge is reduced to the quest for power." - Alston Chase

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    "Coherence between lifestyle factors, including the composition of our diet, is quite obvious from an evolutionary point of view. After all, there was first an environment, and from this environment originated a genome that was adapted to that environment: it is the substrate (environment) that selects the organism, not vice versa. This is exactly what Darwin meant with “conditions of existence,” as the most important driving force in evolution. In other words, our only slowly changing genome is indissolubly linked to a certain environment and lifestyle. However, we have changed this environment since the agricultural revolution and continue to do so with still increasing paste. The resulting conflict does not generate acute toxicity, but acts as an assassin in the long term. Probably, the conflict does not exert much selection pressure either, because its associated mortality occurs mainly after reproductive age.

    ...to solve the conflict, it is virtually impossible to study all of the introduced errors in our lifestyle..."


    ^ Yet this is exactly what Western medicine tries to do, find all the errors induced from living a life outside of the environment to which we are adapted, and marketing a drug for it. The solution, which the authors correctly grasp, is integrating Paleolithic era lifestyle into 21st century culture.

    A brave way forward that is very difficult to do with cognitively impaired citizens.
    Last edited by KimchiNinja; 07-03-2013 at 04:36 AM.

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    KimchiNinja, Yes. They try to remove or cover up the symptoms, thus introducing new and different environmental factors the body has to deal with.
    "When the search for truth is confused with political advocacy, the pursuit of knowledge is reduced to the quest for power." - Alston Chase

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    Thanks for sharing.

    Interesting stat in the paper: brain consumes 20-25% of basal metabolism while skeletal musculature consumes 15%.

    No wonder i stayed thin in university years while eating junk and doing very little exercise. All that high level mathematics would have kept the metabolism high.

    I hope enough people will now read algebra or geometry to lose weight, if not for its own sake!
    Few but ripe.

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