This is a review paper of a number of studies on caloric restriction and longevity on long lived primates, the effect has been seen from the humble round worm C Elegans to fruit fly and many studies on rodents.
These particular studies were started over 30 years ago and research has been continuing, they have found the SIRT1 gene plays a significant role and is upregulated with caloric restriction and hence there has been a race to find chemicals to stimulate this, resveratrol from grape and berry skins is one of these, hence red wine and health, but other research on SIRT1 indicates there is much more to it than just stimulating SIRT1, like everything man is looking for the easy way out, "eat plenty of crap then pop the longevity pill", i think there is only one way and that is CR.
I'd predict that upregulating SIRT1 in the presence of caloric surplus would likely have dire consequences, it's there to keep us alive through caloric shortages.
At bottom is a whole lot of SIRT1 links
Calorie Restriction and Aging in Nonhuman Primates
SIRT1 gene suppresses longevityEffects of CR on Lifespan
The NIA, Wisconsin, and Maryland studies are still under way, so it is too early to identify the precise extent of CR on the animal’s lifespan. However, interim analysis of the Wisconsin study data indicate that control animals at any time had three times the rate of death from an age-related cause compared to the CR monkeys (Colman et al. 2009)—median survival of the control animals has been approximately 27 years, whereas more than 50% of CR monkeys are still living at 31 years of age (all-cause mortality). Interim analysis of the NIA data indicated that twice as many controls as CR monkeys have died of age-related causes (Mattison et al. 2003). And in the Maryland program the median survival for all ad libitum–fed monkeys is approximately 25 years and for the eight CR animals 31 years (Bodkin et al. 2003). Based on the data from these three studies, it seems likely that lifespan will be extended for the monkeys undergoing CR.
Lessons Learned and Future Directions.
CR is the only intervention that has been consistently shown to reduce the incidence, delay the onset, and slow the progression of age-related disease and extend lifespan in short-lived species. The studies described in this article indicate that these effects also occur in long-lived nonhuman primates and suggest that similar mechanisms would be operative in humans.
The Sirt1 Gene Promotes Insulin Secretion in Accord with Diet
Resveratrol Interacts with SIRT1 Gene for Health Benefits | SciTech Daily
SIRT1 gene important for memory
New study validates longevity pathway: Findings identify universal mechanism for activating anti-aging pathway
New experiments clarify the role of SIRT1 in HD - or do they? - HDBuzz - Huntington