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Thread: Is fructose bad for brain inflammation? page

  1. #1
    Aili's Avatar
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    Is fructose bad for brain inflammation?

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    I am curious because I saw on the Wheat Belly FB page today, that fructose is particularly a problem for the brain. Now, I make water kefir and love it. My understanding is that the remaining bit of sweetness is fructose (glucose from sugar used up by the kefir grains) and now I worry. I am 61 years old and really want to protect my brain as much as possible (duh, of course. Do others have thoughts or information about this?
    Much appreciated if you do.

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    magicmerl's Avatar
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    High levels of pure fructose is bad for you, but you can't even get that in SAD foods, let alone a whole foods diet.

    Kefir is awesome.
    Disclaimer: I eat 'meat and vegetables' ala Primal, although I don't agree with the carb curve. I like Perfect Health Diet and WAPF Lactofermentation a lot.

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    cori93437's Avatar
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    If you have normal brain function... enjoy your fruit and kefir all you want!

    Seriously.

    I don't have fully normal brain equipment function and I can still enjoy them in controlled portions.
    “You have your way. I have my way. As for the right way, the correct way, and the only way, it does not exist.”
    ~Friedrich Nietzsche
    And that's why I'm here eating HFLC Primal/Paleo.


  4. #4
    Paleobird's Avatar
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    There is a big difference between slurping down a diet high in HFCS and having an occasional kefir.

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    No. Fructose has documented anticonvulsant activities, and because fructose bypasses certain pathways(along with ketones) it's directly beneficial for seizures and acts as an anti-inflammatory. Fructose is basically like aspirin in this regard.
    nihil

  6. #6
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    Quote Originally Posted by Derpamix View Post
    No. Fructose has documented anticonvulsant activities, and because fructose bypasses certain pathways(along with ketones) it's directly beneficial for seizures and acts as an anti-inflammatory. Fructose is basically like aspirin in this regard.
    Care to back that up?

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    Quote Originally Posted by Paleobird View Post
    Care to back that up?
    Fructose-1,6-Bisphosphate Has Anticonvulsant Activity in Models of Acute Seizures in Adult Rats

    It basically says that when glucose pathways are warped from excess lactate, that fructose can be directly beneficial in this regard. And in all regards.
    nihil

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    Quote Originally Posted by Derpamix View Post
    Fructose-1,6-Bisphosphate Has Anticonvulsant Activity in Models of Acute Seizures in Adult Rats

    It basically says that when glucose pathways are warped from excess lactate, that fructose can be directly beneficial in this regard. And in all regards.


    F1,6BP is a byproduct of glycolysis caused by the breakdown of glucose. Not really the same thing as eating fructose.

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    Quote Originally Posted by canuck416 View Post
    F1,6BP is a byproduct of glycolysis caused by the breakdown of glucose. Not really the same thing as eating fructose.

    From the link:

    Fructose-1,6-bisphosphate (F1,6BP) has actions that suggest it may be an effective anticonvulsant (see Fig. 1). First, F1,6BP has been shown to increase flux of glucose into the pentose phosphate pathway (Kelleher et al., 1995; Espanol et al., 1998) and preserve cellular GSH levels (Vexler et al., 2003). Second, F1,6BP modulates the activity of phosphofructokinase-1 (PFK-1), which is the enzyme that controls the rate-limiting step in glycolysis. F1,6BP is a weak stimulator of PFK-1, but becomes inhibitory in the presence of fructose-2,6-bisphosphate (F2,6BP), a potent activator of PFK-1 (Heylen et al., 1982; Van Schaftingen, 1987). These data suggest that F1,6BP will slightly enhance basal glucose metabolism, but will prevent stimulation of glycolysis by F2,6BP. Diverting glucose from glycolysis toward the pentose phosphate pathway, thus increasing GSH levels while maintaining an energy source for the brain, should provide significant anticonvulsant efficacy.
    And:

    Mathews/van Holde/Ahern 3rd Edition

    I only read the topic title, and was answering a general question.
    nihil

  10. #10
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    Quote Originally Posted by canuck416 View Post
    F1,6BP is a byproduct of glycolysis caused by the breakdown of glucose. Not really the same thing as eating fructose.
    Yeah... I just finished reading. That isn't JUST fructose.

    Eating even sugars from natural sources like fruit can have some negative consequences for people with bum-brains.
    Fructose and glucose both come with their own little issues that don't really bother "normal" people, but can be really serious for others.
    Try talking to a specialist in the field about it... sugars, even fructose (from eating fruit) in large doses can cause problems with inflammation/anti-inflammatory cascades and neuro-excitability that is bad news.
    Last edited by cori93437; 05-07-2013 at 08:58 PM.
    “You have your way. I have my way. As for the right way, the correct way, and the only way, it does not exist.”
    ~Friedrich Nietzsche
    And that's why I'm here eating HFLC Primal/Paleo.


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