I have tried to read the Peat/Roddy stuff on a number of occassions and I find it extremely difficult going, the bulk of it seems to be based on a philosophical presumption and then gathering obscure data to support this presumption.
It does not attempt to answer the confounders of it's own philosophy and with the language being generally emotive and derogatory immediately to me suggests a weak argument, although I am open to new information all the time their writing style is not conducive to their cause.
I am not hard core low carb, don't need to be and where I am suits me fine, but like religious fervour, when their is a declaration of the one true god, my ears prick up, you get a bit sick of the parroting, "eat more sugar, eat more sugar, eat more sugar"
The truth is a VLC diet is inherently stressful and will lower metabolism/reduce thyroid output. Now if you would like to argue if that is necessarily harmful, go ahead. But dont try to say that VLC (enough to elicit gluconeogenesis) does not do these things.
One more time.
There is a difference between a metabolic adjustment and a pathological condition.
VLC is not everybody's cup of tea and is not pushed onto everybody (the low carb police are not out to get you).
But ketosis is a normal bodily state. Ray Peat can keep saying it's stressful and harmful but that doesn't make it true.
If anyone wants a really good book on metabolism, this one is hard to beat: Metabolic Regulation: A Human Perspective
If you read through that book, and this means you Choco, you may come across some interesting facts regarding lactate and pyruvate and obligate glycolytic cells and tissues.
When we talk of "obligate glycolitic" tissues, we are using the word obligate in the sense of obligation, or something that is mandatory, that one must do. Therefore, obligate glycolytic tissues and cells are forced to use glycolysis as their energy source. Normally, the end product of glycolysis, pyruvate, enters the electron transport chain where it generates a whole lot more additional ATP than glycolysis alone. The electron transport chain is part of mitochondrial membranes, so, if you want to use the electron transport chain, you'd better have a whole bunch of mitochondria.
Obligate glycolytic cells do not possess mitochondria so they lack the physical structures necessary to further oxidize pyruvate. Now, as mentioned, the end product of glycolysis is pyruvate and or lactate, both of which are water soluble, that is, they dissolve and circulate in plasma. This is important because while we can measure quantities of lactate in the blood, we do not observe any meaningful levels of pyruvate or lactate in the urine, or in other words, we do not excrete these substances, rather we recycle them. This recycling is ... gluconeogenesis.
So, every second of every day that you are alive, every single red blood cell you possess is merrily churning out glycolytic end products which are carried in the plasma to the liver where they are recycled back into glucose which is then shipped back into the blood stream, or stashed away as glycogen in order to keep those busy little blood cells alive. Gluconeogenesis at its finest. To characterize a process that is ongoing every second of every day in the vast majority of higher order organisms, and certainly in all mammals, as "an emergency mechanism" is nothing but delusional hysteria, or to be kind, represents a gross misunderstanding of the fundamentals of the process.
Furthermore, as to "your body does not want to be in gluconeogensis for prolonged periods of time." You're right, whereas a want is a desire, for your body, gluconeogenesis is a _need_ : a condition necessary for sustaining life.
As far as CO2 production is concerned ... man, Taco, you must make this stuff up as you go along, don't you?
Most organic compounds such as fatty acids, glycerol, carbohydrates and amino acids that have undergone deamination ( removal of the NH3, or amine, group ) have the general complete oxidation formula :
CxHyOz + (x + y/4 - z/2) O2 ---> x CO2 + (y/2) H2O
So the only thing governing CO2 production is the number of carbons in the molecule undergoing oxidation, not lower thyroid activity impacting mitochondrial energy output. Armed with this equation we can predict that the complete oxidation of glucose will yield 6 CO2 molecules, palmitic acid 16, oleic acid 18, alanine ( an amino acid ) 3. The magic is all in the substrate. If all we're after is increasing CO2 output, oxidizing dietary fat is the way to go. Want to minimize CO2 production? Then oxidize some specific short chain amino acids like alanine.
Finally, regarding the study that started this all, it is not very controversial, pretty standard stuff. It is well known that ingested protein stimulates protein synthesis, some of it is directly oxidized, and some amino acids can participate in gluconeogenesis. As there is a limit to how much protein synthesis can occur over a given time frame, when you overeat protein, where overeating merely means exceeding your capacity for protein synthesis, increasing amounts will be shunted into the oxidation and gluconeogenesis pathways.
This study merely set out to confirm that the high thermic effect of protein was due in large part to the relative inefficiency in the gluconeogenetic pathway. Which they effectively confirmed. Move along ... nothing to see here.
Last edited by pklopp; 05-17-2013 at 08:37 AM.
I've said this before and I'll say this again...
I'm HFLC, I also have a brain condition and take a medication that "can" cause some of the conditions that Choco thinks that HFLC can cause such as low CO2. So I get tested regularly for CO2 and other markers, and I've had my every other test under the sun performed because I'm a special goddam snowflake... the vampires take blood; they test for all the things.
My CO2 is always in the med-high normal range. Not low.
My cortisol has never been elevated.
HFLC helps me control that brain condition and is recommended by my Neurologist as perfectly safe... the doctor does not recognize that HFLC is a cause of any of the things that Choco suggests.
I'm under watch and need to be regularly tested because of the medication I have to take. No other reason.
Last edited by cori93437; 05-16-2013 at 10:41 PM.
And that's why I'm here eating HFLC Primal/Paleo.
If you're only looking at the carbons in the molecule undergoing oxidation, the ratio of hydrogen to oxygen in carbs is equal to water. Lipids(fat) contain a lot less oxygen atoms in proportion to hydrogen and carbon, ergo, when fat is degraded it requires a lot more oxygen to oxidize fat to water and co2. So, how exactly, is fat better for producing co2? By wasting more of it? I'm not understanding your logic.