Recently I had a bunch of blood tests done including an NMR lipid panel. Everything is great except for one number. The problem is that some people say that's the only number that matters.

The number is LDL-P, the number of LDL particles, which is 1905. That's officially considered to be "a lot" and puts me somewhere above the 95% percentile. I am aware that there are other people (like Jimmy Moore of the Livin' La Vida Low Carb fame) in the same situation with even worse numbers.

Other things are good: TG 51, HDL-C 80, LDL pattern A, small LDL-P is only 149, HDL-P is 37.1.

LDL-C is 160 which actually seems lowish for the particle number of 1900. My ApoB is 120 which also seems lowish for that LDL-P since each LDL particle has exactly one ApoB molecule. TC is 250.

I am eating nonspecific paleo-style, low-carb (but not VLC, I'm not usually in ketosis). My thyroid panel is normal, TSH is 1.2, free T3 is 3.3. My inflammation markers are low, CRP is 0.47. I don't have glucose problems, HbA1C is 4.9% and the NMR panel gave me the insulin resistance score of 6. I'm not actively losing weight. I doubt I'm copper-deficient as my Ceruloplasmin is 18 which is well within normal range.

So all in all I'm not terribly worried, but I still don't like that LDL particle number. Recent studies like MESA point to the LDL-P being a better predictor of CVD to the extent that once you account for it, other common predictors (like LDL cholesterol, LDL-C, or particle size) become insignificant.

Any comments, ideas, advice?