So when one considers that conventional thinking was completely backward in seeing fat tissue at the bottom of the chain, it is actually at the top. This prompts a completely different way of looking at fat tissue, correcting excessive fat tissue by caloric restriction is not far different from correcting cholesterol levels by reducing intake of saturated fats & dietary cholesterol. Caloric restriction aggravates rather than corrects the underlying problems associated with obesity, it is ultimately a nutritional issue and restricting calories usually results in reduced nutrient intake as well.
Don't expect the medical profession to get there in the near future, just as a bit of an experiment next time you go to see your doc, ask them about a Leptin test, many don't even know about Leptin, let alone a test for it.
Regarding the removal of the pituitary gland as being obsolete comment, well, speaks for itself I suppose, lost for words on that one.