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Thread: Cholesterol Crystals ?

  1. #1
    Join Date
    Apr 2010

    Cholesterol Crystals ?

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    Anyone ever heard of cholesterol crystals? Supposedly they are the starting point for atherosclerosis in the large arteries. Could these be associated with the small LDL particles?

  2. #2
    Join Date
    Feb 2010
    Central NY
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    I skimmed through the paper that article is based on. It sounds like the crystals are made of "minimally-modified LDL" in the body, which is a form of oxidized LDL. (I'm not sure they come out and say that, but injecting pre-crystallized cholesterol or injecting minimally-modified LDL triggered the same pathways in the mice.) And there's evidence that Pattern B (small) LDL particles are more easily oxidized, so in that case you'd be right.

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