From what I could find, the Housekeeper's cut is from the shoulder, so I would think it would do best with low and slow braising. The key to fall apart tender pot roast is to cook it low and slow. If the temperature gets too high, the proteins in the meat will contract too much and expel moisture, becoming tough and dry. Also, if you don't cook it long enough, the collagen will never break down so it will still be chewy. Try cooking it at around 180 F (bare simmer) for 1.5 - 3 hours.
Kenji explains the principles well in this post about chili: The Food Lab: Real Texas Chili Con Carne | Serious Eats



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