That didn't make too much sense because he says that 'fad diets' don't work but the thesis seems to be that all diets don't work, and he concludes that weight loss must be 'over a long period of time' but doesn't specify time.
I lost about 200 lbs after a lifetime of morbid obesity---and I rarely lost more than one pound a week. But I LOST, so although the body may work against fat loss (as is claimed here), it's possible with some effort. I have been maintaining this loss for almost 2 years.
When I read weight-loss boards, I find that most people are looking for some 'effortless' plan that allows them to eat their favorite junk foods. They soon give up and proclaim that they have some 'metabolic dysfunction' that makes it impossible for them to lose weight when the reality is that they are not committed to losing intelligently.
I understand that the body fights weight loss--and I've found maintenance to be even more challenging than losing, as my body seems intent on re-filling those fat cells. I'm not saying this is easy, but nothing worthwhile is achieved without commitment and effort.