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Thread: Asparstame not dangerous after all!

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    Join Date
    Oct 2012

    Asparstame not dangerous after all!

    EFSA the European Food Safety Authority, have another time concluded that there are no health risk involved into a reasonable consume of Asparstame, and that a 60 kg person (132 lbs.) can consume 12 cans of diet soda every day without worrying. Hmmm, seem safe enough to prepare myself the first glass of CokeZero and lime juice for the day then…
    The Panel on Food Additives and Nutrient Sources added to Food provides a scientific opinion reevaluating the safety of aspartame (E951). Aspartame (E 951) is an artificial sweetener authorised as a food additive in the EU that was previously evaluated by JECFA, SCF and EFSA. JECFA and SCF established an ADI of 40 mg/kg bw/day. The Panel based its evaluation on original reports, previous evaluations, additional literature available since these evaluations and the data available following a public call for data. Aspartame is rapidly and completely hydrolysed in the gastrointestinal tract to methanol and the amino acids phenylalanine and aspartic acid. DKP is a degradation product of aspartame. The Panel concluded that chronic toxicity and reproductive and developmental toxicity were the critical endpoints in the animal database. The Panel considered that the evaluation of long term effects of aspartame should continue to be based upon the animal data. Based on a MoA analysis and the weight-of-evidence, the Panel considered that the reproductive and developmental toxicity in animals was due to phenylalanine released from aspartame and concluded that the basis for evaluation of the reproductive and developmental endpoint should be the available data in humans. From the aspartame dose-plasma phenylalanine concentration response modelling, the Panel considered that aspartame intakes up to the ADI of 40 mg/kg bw/day in addition to phenylalanine from a meal would not lead to peak plasma phenylalanine concentrations above the current clinical guideline forprevention of adverse effects in the fetuses of PKU mothers. The Panel concluded that there were no safety concerns at the current ADI of 40 mg/kg bw/day. Therefore, there was no reason to revise the ADI for aspartame. Conservative estimates of exposure to aspartame and its degradation.

    The complete report can be found here:
    Last edited by Gorbag; 01-29-2013 at 09:12 AM.

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