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Thread: Coffee causing Head Fog? page 2

  1. #11
    MudLily's Avatar
    MudLily is offline Senior Member
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    Caffeine is a vasoconstrictor, and therefore decreases blood flow to the brain (and other areas). The short-term effect may be extra energy and focus, but long-term it is harmful. Maybe this is what you are experiencing?

  2. #12
    Derpamix's Avatar
    Derpamix is offline Senior Member
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    Quote Originally Posted by MudLily View Post
    Caffeine is a vasoconstrictor, and therefore decreases blood flow to the brain (and other areas). The short-term effect may be extra energy and focus, but long-term it is harmful. Maybe this is what you are experiencing?
    Caffeine is metabolized into more than 25 metabolites in humans, mainly Paraxanthine, Theobromine, and Theophylline [12] Caffeine metabolism yields paraxanthine as a final product, which represents 72 to 80% of caffeine metabolism. There are five main metabolic pathways which contribute to caffeine metabolism in adults [13, 14]. The first three consist of demethylization of N-3 to form Paraxanthine, N-1 to form Theophylline (vasodilator, increased cerebral and muscular blood flow), and N-7 to form Theophylline (vascular, bronchiole, muscular, and respiratory relaxant). The hepatic cytochrome P-450 (CYP) isoenzyme metabolizes most of the caffeine (95%) by three demethylizations which on average give an in vivo metabolism percentage of 85% paraxanthine, 10% theobromine, and 5% theophylline [15]. The fourth pathway results in the formation of uracil metabolites, and the fifth consists of renal elimination of the remaining percentage of caffeine that was not able to be degraded in the process. The large interindividual differences observed in plasmatic concentration of caffeine following the administration of an equal dose are mainly due to variations in metabolism. These variations depend on four factors: genetic polymorphisms, metabolic induction and inhibition of cytochrome P-450, individual (weight, sex), and the presence of hepatic diseases [14] Caffeine is absorbed rapidly and completely from the intestinal tract, making it 100% bioavailable. The time in which maximum plasmatic concentration is obtained (Tmax) is 30–45 minutes [11, 14, 16, 17] fasting and is delayed with food ingestion; it has an average metabolic half life in humans of 2.5 to 4.5 hours [18]

    Caffeine, by acting on the VSMC, generates a minimal initial contraction and then a significant vasodilator effect. There are various mechanisms that explain these effects.

    Caffeine, by competitively blocking the adenosine receptors, increases its plasmatic concentration [64] which increases its systemic effects. At a systemic level, adenosine stimulates the chemoreceptor distributed throughout the circulation, causing a generalized increase in sympathetic tone, with an increase in circulating catecholamines, peripheral vascular resistance, and renin secretion [44, 65]. Several studies have documented an increase in systolic arterial pressure of 6 to 7.5 mmHg and 2.6 to 4 mmHg in diastolic pressure 60 minutes after the administration of 300 mg of caffeine (equivalent to drinking a triple espresso) [18, 43]. In spite of this “indirect” vasoconstrictor effect produced by caffeine, it is important to point out that the chronic consumption of caffeine creates a tolerance to its adenosine receptor-dependent effects. Chronic blocking of the adenosine receptors, inducing “upregulation” (an increase in the number and sensitivity) of the receptors has been described with a low-moderate caffeine consumption (approximately two cups of coffee for more than 5 days) [66].
    Caffeine is a vasodialtor.
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  3. #13
    Chaohinon's Avatar
    Chaohinon is offline Senior Member
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    My girlfriend is allergic to caffeine and has similar problems with it, a quad shot of espresso will make her sleepy and put her in a weird mental state.

    I definitely agree with Knifegill that it might be something to do with the aflatoxins. Any time I've tried Folgers (or similarly crappy brands) I've ended up feeling sick for days, but local whole bean coffee has never bothered me. I'd recommend trying some freshly-ground, whole bean coffee - ideally from a shop that roasts their own on-site if you can find one in your area - and if you continue having the same symptoms, you can probably assume you're allergic. In that case, I recommend switching to rooibos tea, and using a liquid vitamin B12/b complex supplement for energy.
    “The whole concept of a macronutrient, like that of a calorie, is determining our language game in such a way that the conversation is not making sense." - Dr. Kurt Harris

  4. #14
    Zeera's Avatar
    Zeera is offline Senior Member
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    I had been experiencing these sort of symptoms too, but really never put two and two together that it was my beloved coffee causing me to feel strange until it was suggested to me to cut it out of my diet for a month and then try it again to see how it made me feel. Now if I drink it I feel great for a little while and then I feel kind of cruddy. Could be a caffeine crash I suppose, or it could be something else entirely, I'm really not sure. Unfortunate because I truly love the taste of a high quality cup of coffee.

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