10,000 years ago agriculture was invented and we started ingesting grains that we had never had before. From 10,000 years to now we have ingested a lot of novel foods in comparison to 120,000 years ago.
Surely in that time the body has produced proteins and enzymes (which means altered genes as they are responsible for producing the proteins) to deal with the new foods.
Therefore we are not identical to the paleo people. This seems obvious but mark sisson and other paleo advocates gloss over this point and tell us we are absolutely identical to paleo men and women when we really are not.