Their logic makes sense, and it seems possible, but a few things bother me.
Supporting their argument: Incidence is definitely higher as you move north, and higher glucose levels certainly would prevent tissues from freezing to some degree.
Against: Even though the incidence is higher in northern Europe, it is still relatively low (1 in 2700) compared to other diseases encouraged by secondary selection pressures like sickle cell anemia in Africa (1 in 500). So if there was a benefit, it must have been fairly small.
The big thing that I don't like is that if there was a benefit to elevated glucose levels, I would expect to see a general elevation in fasting glucose levels across the pollution, bot just an extra 10 or 20 people per 100,000 with a sever auto-immune disease. If Scandinavians everywhere had fasting glucose levels that were 10, 20, 30 etc... mg/dl higher than others, I would say absolutely. I don't think this is the case, but I don't know for sure since I can't see the whole paper. It just seems like there are many more ways to select for increased glucose that are less severe than developing an auto-immune response, and I would have thought that those genotypes would be in a population and available for selection. Again, just speculation....
I'm glad you find my articles valuable!
Note that you'll have to buy an actual book if you want to read The Gnoll Credo. Despite what some pirate/torrent websites claim, they don't have the full book available for download - just the teaser you've already read.
edit to add: I see you haven't posted since April, then all of a sudden you and 'The Scientist' start posting really awesome stuff on the same day--are we being set up for something?
Last edited by otzi; 11-25-2012 at 03:54 PM.
Last edited by jojohaligo; 11-26-2012 at 08:32 PM.
Female, age 51, 5' 9"
SW - 183 (Jan 22, 2012), CW - 159, GW - healthy.
Met my 2012 goals by losing 24 pounds.
2013 goals are to get fit and strong!