I'd say yes and no.
No, if your cholesterol is within relatively normal ranges, don't worry about it. However, primal eating and living as advocated by Mark seems to point to slightly different "normal and healthy" ranges than CW would tell you. Tends to be higher.
Yes if you are at the extremes, that is, extremely high, or even MORE dangerous, extremely low. But again, these numbers are changed a bit from the CW wisdom because primal seems to advocate higher overall levels as being healthy and safe.