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What molecules can tell us about white potatoes
Mat Lalonde: Oh, yeah! That’s another one of my favorite, and you know, this one fits this “Well, it wasn’t available before the advent of agriculture, so we probably be shouldn’t be eating it,” again assuming that we cannot find a better source of food compared to what was in the Paleolithic. And this is another one where I covered it at length in my AHS talk, showing the actual molecular structures of these molecules. So some of them are glycosides. They’re either terpene glycosides or they’re alkaloid glycosides. So they’re called saponins or glycoalkaloids, and Cordain makes this huge, huge deal about them, saying that they cause intestinal permeability and whatnot. If you look at those permeability studies, they are all in vitro. And my problem with them is that if you’re a chemist and you look at these substances. They’re like, wow, there are glycoside bonds all over the place. This is gonna fall apart during digestion. Sure enough, it does. Sometimes you can find certain metabolites of it in the bloodstream, but you rarely find that compound itself. It has never been shown in a human being that consuming a lot of this stuff is going to increase intestinal permeability. The only studies that I find where this stuff can be problematic is where they use mice models of intestinal bowel disease, where there’s some kind of genetic manipulation that was done, and they feed those mice models fried potato skins ad libitum. And they’re fried in polyunsaturated oils, by the way.
Chris Kresser: Right, so you take the part of the tuber that has the highest concentration of toxins, which is the skin, and then you fry it in seed oil.
Mat Lalonde: Yeah, in a mouse model of IBD. And if you do that, you see inflammation, biomarkers of inflammation increase. So if, and this is a big if, that translates to human beings, all you’d be able to say is that people with irritable bowel disease should not be eating fried potato skins ad libitum. If you think that’s a ridiculous statement, you’re right.