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Thread: Vaccine for Artherosclerosis, looking deeper to the causes of CHD page

  1. #1
    Omni's Avatar
    Omni is offline Senior Member
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    Vaccine for Artherosclerosis, looking deeper to the causes of CHD

    Just searching around for cholesterol stuff and found this:
    Inhibition of T cell response to native low-density lipoprotein reduces atherosclerosis

    Seems the Immune system T-cells play a significant role in CHD:
    Immune responses to oxidized low-density lipoprotein (oxLDL) are proposed to be important
    in atherosclerosis. To identify the mechanisms of recognition that govern T cell responses to
    LDL particles, we generated T cell hybridomas from human ApoB100 transgenic (huB100tg)
    mice that were immunized with human oxLDL. Surprisingly, none of the hybridomas responded
    to oxidized LDL, only to native LDL and the purified LDL apolipoprotein ApoB100.
    However, sera from immunized mice contained IgG antibodies to oxLDL, suggesting that
    T cell responses to native ApoB100 help B cells making antibodies to oxLDL. ApoB100
    responding CD4+ T cell hybridomas were MHC class II–restricted and expressed a single T cell
    receptor (TCR) variable (V)  chain, TRBV31, with different V chains. Immunization of
    huB100tgxLdlr/ mice with a TRBV31-derived peptide induced anti-TRBV31 antibodies
    that blocked T cell recognition of ApoB100. This treatment significantly reduced atherosclerosis
    by 65%, with a concomitant reduction of macrophage infiltration and MHC class
    II expression in lesions. In conclusion, CD4+ T cells recognize epitopes on native ApoB100
    protein, this response is associated with a limited set of clonotypic TCRs, and blocking
    TCR-dependent antigen recognition by these T cells protects against atherosclerosis.

  2. #2
    Dirlot's Avatar
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    Makes sense...I guess a vaccine could be good OR you could eat Primal!
    Eating primal is not a diet, it is a way of life.
    PS
    Don't forget to play!

  3. #3
    Omni's Avatar
    Omni is offline Senior Member
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    Primal Blueprint Expert Certification
    Quote Originally Posted by Dirlot View Post
    Makes sense...I guess a vaccine could be good OR you could eat Primal!
    Most likely right, since Primal improves Blood Sugar control and diabetes is a major risk factor in CHD:
    How Diabetes Drives Atherosclerosis

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