I can lose weight easily if the calorie deficit is from extreme physical exertion. If it's a calorie deficit while I sit at work, my body adjusts to lose no weight at all and drive me crazy with hunger. I can actually eat a calorie surplus sitting at my job all day and do okay so long as it's lower carb primal fare. At this point, now that I'm not fat anymore, the most effective loss comes from extreme exercise. And not weight lifting. That does nothing for weight loss for me. Might tone me, but doesn't make me thinner.
Female, 5'3", 49, Starting weight: 163lbs. Current weight: 135 (more or less).
Starting squat: 45lbs. Current squat: 160 x 2