Well dyslipidemia is definitely a contributor and that is characterized by Low HDL, elevated LDL (pattern B small dense) and high triglycerides.
Chronically elevated insulin levels will also cause problems and if sugar (particularly fructose) stays in the blood too long it can cause damage.
Endogenous and exdogenous free radical production will also play a role. Fructose is 7 times more effective at forming AGE's than glucose, heating unstable fat at high temperatures wil also lead to the production of free radicals. These can cause cellular damage and DNA damage.
A poor omega 3 - 6 balance will also cause excessive chronic inflammation. Eicosanoids (cell to cell signalling molecules) derived from Omega 6's tend to be more pro-inflammatory and there are way too many omega 6's in the western diet. Reducing vegetable oils and grains helps so does conosuming more fish, free range eggs, vegetables and grass fed meat.