I like to take mine around my meals, with the exception of ZMA and more vit d before bed. Helps me sleep a little better. I stopped taking a multi since according to fitday I'm getting plenty of most nutrients. Other than those two I take Vit e, selenium, and some calcium since I don't get a lot from food.
IMO if you're eating a variety of primal foods, a multi is a waste of money and you need only supplement with maybe a few things.