From Dr. Kruse's eating disorder blog:
@ C I think Leptin Rx witht he AI protocol is a good call by you. Be patient and listen to Momma Grok……her and I fought for a while and now she is approaching rockstar status. All these diseases are closely related and I think they are all caused by the same pathophysiology I think the main difference is the severity of the cortisol response that set it off really help determine which mismatch you get. I think AN is truly an transgenerational epigenetic disease but medicine is not close to buying it. Too many young girls have a family history on the maternal side that fits and the more we learn about epigenetics the more I believe my instincts are correct here.
PS. Momma Grok is a couple of pounds from her goal and she is no longer binging……and no I did not do any psychotherapy on her……..just brain surgery without a scalpel.
@Syl…….I have never believe that AN or BN were purely psychiatric diseases. I always felt there was some brain gut axis problem associated with it but I did not put it together until I linked the incretins with the hypocretins and found out leptin controlled both. Then is made sense. The Leptin Rx works for many with these disorders because it forces the “BAD BRAIN BDNF” to get back to working eventually. MommaGrok is a perfect example. It may take longer than you want but eventually it will force them to once again be yoked together.
BDNF, huh... I see long-term memory, will have to see how it's connected to incretins or hypercretins or EDs. Gah, to think that I did not realize until a few months ago that I had an eating disorder. As if not being able to stop thinking about, and indulging in, grains & sugar ALL DAY LONG isn't disordered! As if eating half a carton of ice cream and/or half a cereal box of granola, every day, is not disordered! I thought I was just a glutton. Sheesh.
I never thought about the cortisol from the physical, emotionally, etc., abusive HS boyfriend. The timing is ... curious. I never felt stressed during that time or even during the four years in engineering school, but ... the timing is impeccable. ?
Approaching rock star status .... prepare for liftoff!!
@Momagrok……not syaing its fully functional yet, but you are getting there. BDNF is what really fixes those with ED and many other mental illnesses like depression. BDNF allows neural circuitry repair to happen where damage has taken a deep toll
@Dan there is no authority here. I have had the pleasure of treating many with spine disease who also have had ED. The interesting thing I have noticed that most have this binge disorder for most of their life and treatment is woeful. When I started to formulate the Leptin Rx in 2007 I spoke to several bariatric surgeons about their bingers and purgers and they told me that all their disorders improve after their vagus was cut from their stomachs. I knew that had to mean something physiologically. So the Leptin Rx is a way to force the brain to become plastic by causing it to rewire. It does the same thing a bariatric surgeon does but without a knife. And after sometime…….bingers and purgers have told me they have had remarkable changes in their behavior. I call it a solid unintended consequence. The more I researched the mechanism…….and saw the incretins and hypocretins and leptin with the vagus all together I knew there was more physiologic to the story that their was psychiatric. BN has woeful treatment numbers from conventional psychiatry. So I think those who have it and want to try a Leptin Rx reset certainly are not going to hurt themselves eating a paleo diet in a special way for a period of time. This is how a clinician pays attn to his patients and observes things closely and then talks to surgeons who routinely slice open the guts of fat and purging patients and talk to them to gain insights. I do not believe there is any data to support a set point for fatness at all.
Dan H basically asks if food reward is not part of it for the bulimic eating SAD processed food
@Dan H after it is hard wired you are correct. I am addressing the proximal pathophysiology. How to fix it now no one has a great answer. I think my rewiring protocol wont hurt and may help a great deal. The best part…….it certainly wont hurt them any more than they have been. The longer you have an ED the longer you have to apply the Leptin Rx reset. Momagrok is a perfect example. It took her a while but she is now one third of year with no binges.
@Meghan Yes antibiotics do affect appetite. Anything that changes gut flora can affect teh incretin hormone response via the vagus nerve. The usual result is an increase in agouti and NPY to increase hunger. Candida also increases PYY. A word on GAPS…….it does nothing for this issue. In fact anyone who uses GAPS thinks it works on all leaky guts. It does not. The big hole in GAPS is that if you hve a eukaryotic infection in the gut like Candida or C diff GAPS wont do a thing. You need to go beyond it. See my Leaky gut Rx for beyond it……..that would be IV glutathione etc.
Andrea asked basically, what is the difference between the obese and those who develop EDs?
@Andrea its pretty simple. The obese alone have a excessive cytokine load that is structurally related to leptin and leptin alone. The excess cytokines cause the leptin receptor to not account for calories as it should. The pathways from the gut to the brain are working perfectly fine and the temporal signaling is not a problem. The obese initially did not start with high cortisol levels…….excessive leptin levels cause high cortisol levels as time goes and they develop obesity. All ED patients start with high cortisol as their basis that causes the disruption. ED patents have a leptin problem caused by a cortisol problem that destroys the normal signaling between the gut and the brain between the incretin gut hormones and leptin neurons in the brain. The pathways are not broken they just do not signal correctly temporally.
Last edited by MamaGrok; 02-06-2012 at 08:23 AM.
5'4" 39yo mother to five sweeties & married to their AMAZING DaddyGrok
*Current Weight: 175lb___________________________________*Goal: 135lb
*Deadlift: 225x4_________________________________________*Bac k Squat: 155x2
*Bench: 125x2__________________________________________*Pr ess: 80x1
***Winning a 20-year war against binge eating disorder***