Yes. I fell off the paleo wagon over the summer and was totally out of control with carbs. I'm talking ice cream every day, chips, big bowls of popcorn every night. One of my liver enzymes (forget which one) was up to 200 in mid-August. I immediately went low-carb and by early October, it was almost back in range, just a couple points over. I've gone even stricter paleo since then, lost 20+ pounds, and I expect it would be in range if I tested it today.