I noticed that after I got past the first 20 or so pounds, I started seeing significant changes in the fit of my clothes more frequently. Of course, that could also be because I was squeezing myself into clothes that were a half-size to a size smaller than what I should have been wearing, but it's nice to know that the skirts that were tight on me last winter have gone from fitting "just right" to feeling loose in a matter of weeks.
If you are interested in some size 18 slacks (Lee brand) from Kohl's that I got last fall, I will be happy to send them to you for free. I did have to have them hemmed, but I'm 5' 6" so they're not too short. I would be happy to send you the inseam measurement if you like.