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Thread: High Carb Diet = Cancer? page

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    SerialSinner's Avatar
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    [quote]

    Two major conclusions emerge from the hypothesis; first that many cancers can regress if energy intake is restricted and, second, that many cancers can be prevented if energy intake is restricted. Consequently, energy restricted diets combined with drugs targeting glucose and glutamine can provide a rational strategy for the longer term management and prevention of most cancers.
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    Full Text (PDF): http://2.ly/huy

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    Nora Gedgoudas has a similar discussion about this in her book, "Primal Body-Primal Mind".

    “It is a truism that almost any sect, cult, or religion will legislate its creeds into law if it acquires the political power to do so, and will follow it by suppressing opposition, subverting all education to seize early the minds of the young, and by killing, locking up, or driving underground all heretics.”
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    SS, your quote says nothing about carbs at all. It says restricting energy intake is important...as in how much food you eat.


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    I presume the bit about "drugs targeting glucose..." is the clincher?


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    The quote SS chose doesn&#39;t mention carbs, but the paper provides more detail, arguing that cancer cells are almost always glucose-dependent, and cannot run on fatty acids like most normal cells can.


    I suspect the authors focused more on the calorie-restricted diets in the paper because there&#39;s a lot more data on those. However, the authors&#39; research program focuses on the use of ketogenic diets to complement cancer therapy, so perhaps we&#39;ll be hearing more about that in the future.


    He does admit somewhere in that paper that the calorie-restricted diets that have been shown effective in rats would be the equivalent of 500-600 calorie per day diets for humans. That might be impossible for most humans, but a bit higher wouldn&#39;t be very difficult as long as one went very low carb.


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    Asturian's Avatar
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    Article also mentioned that ketone energy source protects mitochondria. So that sound to me like fat based energy is preferred over carb based glucose energy.

    “It is a truism that almost any sect, cult, or religion will legislate its creeds into law if it acquires the political power to do so, and will follow it by suppressing opposition, subverting all education to seize early the minds of the young, and by killing, locking up, or driving underground all heretics.”
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    Caloric restriction in a high carb diet = lower glucose, but as some mentioned before, a low-carb ketogenic diet would prevent starvation while lowering glucose, probably even more than a calorie-restricted high-carb diet + drugs.


    There are also lot&#39;s of papers suggesting ketogenic diets as a metabolic treatment for ongoing cancers. It&#39;s just a matter of connecting the dots...

    “Every saint has a past and every sinner has a future.” -Oscar Wilde
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    Low calorie diets is a common trait of the "Blue Zones."


    Cutting the the refined carbs and sugars would also be a logical first step in reducing energy intake.


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    http://high-fat-nutrition.blogspot.com/search/label/Cancer%20and%20ketones


    I don&#39;t have the study at hand, but...


    Apparently low calorie ketosis (ZC) works very well for brain cancer. The cancer can&#39;t get any glucose to survive in the skull. I don&#39;t think it works as well elsewhere in the body as the cancer can feed off of surrounding glucose (which isn&#39;t as available in the brain).


    There was a study done with brain cancer patients that were out of options. They had already undergone radiotheraphy/chemotherapy.

    They were put on a low calorie ZC diet and it saved some of them.


    A large percentage of the study group gave up on the diet and died.

    The "Seven Deadly Sins"

    • Grains (wheat/rice/oats etc) . . . . . • Dairy (milk/yogurt/butter/cheese etc) . . . . .• Nightshades (peppers/tomato/eggplant etc)
    • Tubers (potato/arrowroot etc) . . . • Modernly palatable (cashews/olives etc) . . . • Refined foods (salt/sugars etc )
    • Legumes (soy/beans/peas etc)

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    Yes, there's mounting evidence that high carb, especially high fructose in an unnatural form, raises risk of cancers.

    Cancer causes: 'Healthy' fruit juice has so much sugar it could bring on tumours | Mail Online

    Fructose is about 100 times as mutagenic as glucose (mutagenic means damaging to DNA - and DNA mutations are a major contributing cause of cancer). When it's consumed in the form of white sugar and HFCS and even large amounts of fruit juices, it's absorbed sufficiently quickly that the liver becomes overloaded in detoxing it from the body. The liver is a powerhouse of the immune system so when it's preoccupied with detoxing fructose it has to cease assisting the immune system eliminate cancerous or pre-cancerous cells from the body.

    Glucose is also problematic when blood glucose goes too high on a regular basis. A high-carb low-fat diet, especially alongside a sedentary lifestyle, eventually will cause insulin resistance and raised blood glucose levels.

    It's been shown that some cancer cells begin to start expressing genes for fructose transporters so that they can guzzle up fructose from the blood stream:

    Cancer cells slurp up fructose, US study finds | Reuters

    There's evidence for breast, colon and pancreatic cancer cells doing this.

    Note: normally only liver cells take up fructose so it can be detoxed to fat or glucose. If it's detoxed to fat (which is pretty much guaranteed when glucose is abundant) that's predominantly to the saturated fatty acid palmitic acid that has been shown to contribute to insulin resistance (note that palmitic acid is unlikely to be be produced in excess in a primal low/moderate carb diet and it's only present in low amounts in most primal foods):

    JCI - Palmitic acid mediates hypothalamic insulin resistance by altering PKC-&#x003b8; subcellular localization in rodents
    Last edited by paleo-bunny; 02-29-2012 at 12:29 PM. Reason: grammar
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