So the New England Journal of Medicine just came out with a paper explaining the role of hormones (leptin, ghrelin, insulin) in regaining weight after a severely calorie restricted diet. This was reported by NPR:

Hormones And Metabolism Conspire Against Dieters : Shots - Health Blog : NPR

I don't imagine that many people here will be surprised by these findings, but I would be interested in reading your thoughts. Leptin resetters? IFers? what is your experience?