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Thread: Leptin resistance (new post by Stephan) page 2

  1. #11
    Anand Srivastava's Avatar
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    Another post on the thread at wholehealthsource says that leptin secretion is affected by O6. That might lead to metabolic syndrome.


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    Asturian's Avatar
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    Anand, What did you mean by HG group? Haplogroup?


    I was thinking more of whole body low-grade systemic inflammation and not just hypothalamus.


    Perhaps the Kitavans have a gene that suppresses TG and/or insulin based inflammation?

    “It is a truism that almost any sect, cult, or religion will legislate its creeds into law if it acquires the political power to do so, and will follow it by suppressing opposition, subverting all education to seize early the minds of the young, and by killing, locking up, or driving underground all heretics.”
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    Anand Srivastava's Avatar
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    Sorry, I thought HG is readily understood as Hunter Gatherer on this site ;-).


    Actually Leptin sensitivity is based only in Hypothalamus. It is different from Insulin sensitivity which is based in all cells.


    The kitavans do have high TG (not very high though), compared to the swiss control group (in the study). So there is no gene that suppresses TG. We don't think that they have any specific adaptation. Genetic differences work on individual basis, not on a tribe as a whole. They do get metabolic syndrome when they eat SAD, so they are not any different.


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    Asturian's Avatar
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    Thanks for the HG clarification.


    What Dr. Galland was proposing is that there is a complex relationship between our fat cells and inflammation. He proposes that our fat cells are part of both the immune and endocrine system. He says that obesity leads to chronic low-grade inflammation which in turn causes leptin resistance as well as insulin resistance. Both then return the favor and cause obesity.


    He makes the following statement ...


    Chronic low-grade inflammation makes your brain and body resistant to the normal regulatory effects of leptin and other hormones, including insulin and cortisol.

    Perhaps when he wrote this he was unaware that leptin resistance only occurs in hypothalamus ... which makes sense to me btw. Or perhaps he is referring to all of the metabolic hormones becoming resistant for body and brain?

    “It is a truism that almost any sect, cult, or religion will legislate its creeds into law if it acquires the political power to do so, and will follow it by suppressing opposition, subverting all education to seize early the minds of the young, and by killing, locking up, or driving underground all heretics.”
    —Robert A. Heinlein

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    I am also concerned, as some pointed out before, with chronic inflammation, it's potential in/direct effects on leptin sensitivity and the role of starch in promoting it.


    Ananad makes a good point on that the Kitavans seem healthy regardless of their starch consumption, and that they too seem to develop metabolic syndrome when switching to the SAD.


    However, we appear to have only superficial assessments of the real health of Kitavans, as expressed by Dr. Harris: http://2.ly/ghb


    Clean sources of glucose appear to be way better than other sources of carbs, but I am still hesitant to include it as an ideal dietary component for someone seeking their highest level of health possible...

    “Every saint has a past and every sinner has a future.” -Oscar Wilde
    "The power of accurate observation is commonly called cynicism by those who have not got it." -George Bernard Shaw
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    SerialSinner wrote:


    "Clean sources of glucose appear to be way better than other sources of carbs, but I am still hesitant to include it as an ideal dietary component for someone seeking their highest level of health possible."


    This is also my stance. A certain practice by a culture or even by our Paleolithic ancestors does not necessarily open the door for its adoption in our own lives.


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    Leptin controls food intake and energy expenditure by acting on receptors in the mediobasal hypothalamus.


    If those receptors lose their sensitivity you have leptin resistance. If inflammation is the cause of the receptors losing their sensitivity then you have a solid argument that anti-inflammatory diet and exercise would be natural steps to take to reverse or prevent leptin resistance.


    Does it make sense that all or many receptors in our body lose their sensitivity due to inflammatory conditions and if so would they not regain some or all sensitivity by removing that inflammatory condition?


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