People suffering from ME, chronic fatigue syndrome, fibromyalgia and some other debilitating conditions often have difficulties introducing probiotics. The reason for that is the die-off effect: it is so severe in this group of patients that they find it very difficult to cope with. Just start from a tiny amount and go up very slowly. I have patients who start from 1/18th of a capsule of the Bio-Kult (or as much powder as would fit on the end of a sharp knife), and it takes them months to get up to one capsule per day. The same with fermented foods, start from a tiny amount per 5-7 days; as your body gets used to that amount, start taking it a bit more frequently. When you can take that tiny amount every day, start increasing the dose. Proceed in this very slow manner. It is important for you to introduce probiotics in the form of food or supplement. You just have to go slowly.