My meds have decreased fairly steadily since starting primal, but it is hard for me to know if this is related to weight or to underlying healing. I have been one of these people who have tended to yoyo in the level of med I have needed, so having a continual decrease is good. I have gone from 50mg cytomel (T3) down to 36.25 mg per day, and I am due for another blood test in another couple of weeks. I am feeling like I have stabilized, and if I have that is ok with me. Needing to take no meds would be great, but even getting to the point where the meds I need are stable would be wonderful. I have the sense that if it is possible, it may take a long time, and probably depends on if there was permanent damage done.